Scientific and standardization committee communications: classification and nomenclature of snake venom C‐type lectins and related proteins

Non-enzymatic proteins from snake venoms: A gold mine of pharmacological tools and drug leads

“…Since its first characterization (Prado-Franceschi and Brazil, 1981), much has been learned about convulxin. It is a heterodimeric tetramer protein of approximately 84,000 Da size, with one subunit of 135 amino acid residues and a second of 125 amino acid residues (Leduc and Bon, 1998), and belongs to the family of the snaclecs (snake C-type lectins; Polgar et al, 1997;Clemetson et al, 2009). Within mammalian prey, convulxin acts by inducing platelet aggregation through binding and clustering of the p62/GPVI collagen receptor (Jandrot-Peruus et al, 1997) and can bind eight GPVI (Horii et al, 2009) (Fig.…”

Protein complexes in snake venom

“…This group of non-enzymatic proteins in snake venom is growing in number and has been renamed as Snaclecs (Snake venom C-type lectins) by the Registry on Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Hemostasis [134]. Snaclecs have two structurally similar subclasses of proteins, namely CTLs and CLRPs.…”

Radiation Toxins - Effects of Radiation Toxicity, Molecular Mechanisms of Action, Radiomimetic Properties and Possible Countermeasures for Radiation Injury

“…(see Table 5) (see table 6) Neurotoxic proteins can be isolated from various snake venoms. These proteins can potentially be a mix of neurotoxins ,which attack the nervous system; hemototoxins, which attack the circulatory system; plus cytotoxins, bungarotoxins and many other toxins that affect the body in different ways [6,29,49,60,61,82,83,84,85]. Almost all snake venom contains hyaluronidase, an enzyme that ensures rapid diffusion of the venom into the body of the bite-victim [82,84].…”