Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota

Chen, Lin; Jiang, Qihong; Jiang, Chenkai; Lu, Haojie; Hu, Wenjun; Yu, Shaofang; Li, Mingqian; Tan, Chin Ping; Feng, Yongcai; Xiang, Xingwei; Shen, Guoxin

doi:10.1039/d2fo02524h

Cited by 13 publications

(3 citation statements)

References 46 publications

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“…It is hypothesized that Sciadonic acid might have a positive influence on STC. [ 43 ] However, the effect and mechanism of TKO on STC has not been further explored. Hence, the main purpose of the study was to investigate the positive regulatory effect of TKO on LOP‐induced STC in vivo.…”

Section: Discussionmentioning

confidence: 99%

Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice

Wang,

Guo,

et al. 2023

Molecular Nutrition Food Res

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ScopeTorreya grandis kernel has traditionally been used to remove intestinal parasites and increases intestinal motility. However, the effect of Torreya grandis kernel oil (TKO) on constipation has not yet been investigated. Therefore, mouse model is used to investigate the effect of TKO on slow transit constipation (STC) and its possible mechanism.Methods and resultsThe effects of TKO on intestinal motility of STC mice are evaluated by fecal weight, fecal water content, colon length, defecation test, and intestinal propulsion test. The mechanism of TKO alleviating STC is explored by detecting biochemical analysis, histological analysis, western blot, qRT‐PCR, immunohistochemistry, and gut microbiota analysis. The results reveal that TKO effectively promotes defecation and intestinal motility, increases the level of endothelin‐1, and restores the histopathological morphology of the colon under LOP pretreatment. The expression levels of occludin, claudin‐1, and zonula occludens‐1 (ZO‐1) mRNA and protein are up‐regulated in mice receiving TKO treatment. The colonic 5‐hydroxytryptamine 3R/4R (5‐HT3R/5‐HT4R) expressions are also increased by TKO supplementation. Additionally, TKO rescues LOP‐caused disorders of the gut microbiota.ConclusionConsumption of TKO is beneficial to STC recovery, and it can alleviate LOP‐induced STC by up‐regulating the colonic expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R.

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Section: Discussionmentioning

confidence: 99%

Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice

Wang,

Guo,

et al. 2023

Molecular Nutrition Food Res

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“…13 In addition, SC was detected to activate the expression of the PPARα/SREBP-1C/FAS protein pathway and regulate lipid metabolism. 14 Despite such effects, whether SC can positively affect bone metabolism disorders related to HFD remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Yao,

Lu,

Zhou

et al. 2024

Food Funct.

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“…The seed oils are rich in several UFAs, including linoleic (39.39–47.77%), oleic (30.47–37.54%) and eicosatrienoic acids (6.78–8.37%) 17 . Sciadonic acid (SA) is a polyunsaturated fatty acid (5c, 11c, 14c‐eicosatrienoic acid) with hypoglycemic 18 and lipid metabolism‐promoting activities 19 . Several studies showed that UFAs are authentic immunosuppressors and appear to exert beneficial effects with respect to certain immune‐mediated diseases.…”

Section: Introductionmentioning

confidence: 99%

Sciadonic acid ameliorates cyclophosphamide‐induced immunosuppression by modulating the immune response and altering the gut microbiota

Chen,

Jiang,

Yao

et al. 2024

J Sci Food Agric

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BACKGROUNDCyclophosphamide (Cy) is a frequently used chemotherapeutic drug, but long‐term Cy treatment can cause immunosuppression and intestinal mucosal damage. The intestinal mucosal barrier and gut flora play important roles in regulating host metabolism, maintaining physiological functions and protecting immune homeostasis. Dysbiosis of the intestinal flora affects the development of the intestinal microenvironment, as well as the development of various external systemic diseases and metabolic syndrome.RESULTSThe present study investigated the influence of sciadonic acid (SA) on Cy‐induced immunosuppression in mice. The results showed that SA gavage significantly alleviated Cy‐induced immune damage by improving the immune system organ index, immune response and oxidative stress. Moreover, SA restored intestinal morphology, improved villus integrity and activated the nuclear factor κB signaling pathway, stimulated cytokine production, and reduced serum lipopolysaccharide (LPS) levels. Furthermore, gut microbiota analysis indicated that SA increased t beneficial bacteria (Alistipes, Lachnospiraceae_NK4A136_group, Rikenella and Odoribacter) and decreased pathogenic bacteria (norank‐f‐Oscillospiraceae, Ruminococcus and Desulfovibrio) to maintain intestinal homeostasis.CONCLUSIONThe present study provided new insights into the SA regulation of intestinal flora to enhance immune responses. © 2024 Society of Chemical Industry.

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Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota

Abstract: This study aimed to evaluate the effects of sciadonic acid (SC) on lipid metabolism and gut flora in mice fed with high-fat diet. The results showed that SC activate the...

Cited by 13 publications

References 46 publications

Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice

Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice

Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Sciadonic acid ameliorates cyclophosphamide‐induced immunosuppression by modulating the immune response and altering the gut microbiota

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