Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Yao, Shiwei; Lu, Hongling; Zhou, Tianhuan; Jiang, Qihong; Jiang, Chenkai; Hu, Wenjun; Li, Mingqian; Tan, Chin Ping; Feng, Yongcai; Du, Qun; Shen, Guoxin; Xiang, Xingwei; Chen, Lin

doi:10.1039/d3fo04527g

Food Funct.

2024

DOI: 10.1039/d3fo04527g

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Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Shiwei Yao,

Hongling Lu,

Tianhuan Zhou

et al.

Abstract: High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SA), one of the main nutritional and functional components...

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Functional compounds of Torreya grandis nuts and their processing byproducts: Extraction process, health benefits, and food applications – A comprehensive review

Zongo,

Jin,

Hao

et al. 2024

Food Research International

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Functional compounds of Torreya grandis nuts and their processing byproducts: Extraction process, health benefits, and food applications – A comprehensive review

Zongo,

Jin,

Hao

et al. 2024

Food Research International

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Psidium guajava Seed Oil Reduces the Severity of Colitis Induced by Dextran Sulfate Sodium by Modulating the Intestinal Microbiota and Restoring the Intestinal Barrier

Zhang,

Shen,

et al. 2024

Foods

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The oil derived from Psidium guajava seeds (TKSO) exhibits an abundance of diverse unsaturated fatty acids, notably oleic, linoleic, and α-linolenic acids, conferring substantial health advantages in addressing metabolic irregularities and human diseases. This research endeavor focused on elucidating the impacts of TKSO on colonic inflammatory responses and intestinal microbiota alterations in a murine model of colitis induced by dextran sulfate sodium (DSS), demonstrated that substantial supplementation with TKSO reduces the severity of colitis induced by DSS. Furthermore, TKSO effectively attenuated the abundance and expression of proinflammatory mediators while augmenting the expression of tight junction proteins in DSS-challenged mice. Beyond this, TKSO intervention modulated the intestinal microbial composition in DSS-induced colitis mice, specifically by enhancing the relative presence of Lactobacillus, Norank_f_Muribaculaceae, and Lachnospiraceae_NK4A136_group, while concurrently diminishing the abundance of Turicibacter. Additionally, an analysis of short-chain fatty acids (SCFAs) revealed noteworthy elevations in acetic, propionic, isobutyric, and butyric acids, and total SCFAs levels in TKSO-treated mice. In summary, these findings underscore the potential of TKSO to reduce the severity of colitis induced by DSS in mice through intricate modulation of the intestinal microbiota, metabolite profiles, and intestinal barrier repair, thereby presenting a promising avenue for the development of therapeutic strategies against intestinal inflammatory conditions.

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Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Abstract: High-fat diet (HFD) has been associated with certain negative bone-related outcomes, such as bone metabolism disruption and bone loss. Sciadonic acid (SA), one of the main nutritional and functional components...

Cited by 2 publications

References 50 publications

Functional compounds of Torreya grandis nuts and their processing byproducts: Extraction process, health benefits, and food applications – A comprehensive review

Functional compounds of Torreya grandis nuts and their processing byproducts: Extraction process, health benefits, and food applications – A comprehensive review

Psidium guajava Seed Oil Reduces the Severity of Colitis Induced by Dextran Sulfate Sodium by Modulating the Intestinal Microbiota and Restoring the Intestinal Barrier

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