Schwannoma—A Rare Subepithelial Lesion of the Colon

Barbeiro, Sandra; Martins, Catarina; Gonçalves, Cláudia; Arroja, Bruno; Canhoto, Manuela; Silva, Filipe; Cotrim, Isabel; Amado, Cristina; Eliseu, Liliana; Vasconcelos, Helena Baldez

doi:10.1016/j.jpge.2015.01.006

Cited by 10 publications

(14 citation statements)

References 16 publications

(37 reference statements)

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“…For differential diagnosis of schwannoma, abdominal CT scan can help differentiate between schwannoma and other mesenchymal tumors. Schwannomas appear as well-defined homogenous mural masses with low enhancement [ 1 , 5 , 7 , 10 , 11 , 14 , 35 , 36 , 40 , 51 , 70 ] in comparison with the heterogenous aspect of GIST and the ill-defined aspect of adenocarcinomas [ 72 ]. Less than half of the published case reports had a CT scan done, approximately half of these had endoluminal resection and did not require abdominal imaging.…”

Section: Discussionmentioning

confidence: 99%

Schwannoma of the colon and rectum: a systematic literature review

et al. 2018

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BackgroundSchwannomas of the colon and rectum are rare among gastrointestinal schwannomas. They are usually discovered incidentally as a submucosal mass on routine colonoscopy and diagnosed on pathologic examination of the operative specimen. Little information exists on the diagnosis and management of this rare entity.The aim of this study is to report a case of cecal schwannoma and the results of a systematic review of colorectal schwannoma in the literature.Main bodyPubMed, Scopus, and Cochrane database searches were performed for case reports and case series of colonic and rectal schwannoma.Ninety-five patients with colonic or rectal schwannoma from 70 articles were included. Median age was 61.5 years (59% female). Presentation was asymptomatic (28%), rectorrhagia (23.2%), or abdominal pain (15.8%). Schwannoma occurred in the left and sigmoid colon in 36.8%, in the cecum and right colon in 30.5%, and in the rectum in 21.1%. Median tumor size was 3 cm and 56.2% of patients who underwent preoperative colonoscopy had a typical smooth submucosal mass. At pathology, 97.9, 13.7, and 5.3% of schwannomas stained positive for S100, vimentin, and GFAP, respectively. The median mitotic index was 1/50.ConclusionsColorectal schwannoma is a very rare subtype of gastrointestinal schwannoma which occurs in the elderly, almost equally in men and women. Schwannoma should be included in the differential diagnosis of a submucosal lesion along with gastrointestinal stromal tumor, neuro-endocrine tumors, and leiomyoma-leiomyosarcoma. Definitive diagnosis is based on immunohistochemistry of the operative specimen. Rarely malignant, surgery is the mainstay of treatment.

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Section: Discussionmentioning

confidence: 99%

Schwannoma of the colon and rectum: a systematic literature review

et al. 2018

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“…El diagnóstico diferencial debe considerar otras lesiones subepiteliales, como lipoma, neurofibroma, linfoma, tumores neuroendocrinos u otras lesiones (endometriosis, compresión extrínseca). La inmunohistoquímica muestra una alta reactividad a la proteína S-100 en las células tumorales y negatividad para CD34, CD117, citoqueratina y cromogranina 1,7,12 . Los tumores del estroma gastrointestinal son negativos para S-100 y positivos para CD34 y CD117, y los leiomiomas pueden expresar S-100, pero también desmina y actina.…”

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Schwanoma de colon derecho tratado por colectomia laparoscópica

2019

Rev. Cirugia

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Introducción: Presentamos un caso infrecuente de Schwanoma de colon derecho tratado por una colectomía laparoscópica.Caso Clínico: La presentación clínica fue de un tumor sub epitelial del colon derecho que cursa con anemia. La resección fue realizada por vía laparoscópica sin incidentes posoperatorios. El diagnóstico fue realizado por la histopatología y la inmunohistoquímica que mostró una positividad intensa para S100 en las células tumorales con un índice de proliferación KI67 menor al 1%, por lo que se concluye que se trata de una lesión benigna.

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“…Colonic schwannomas are exceedingly rare tumors, with very few cases reported in the literature. Although generally regarded as benign lesions, malignant transformation has occasionally been described . Endoscopic resection of these and other colonic SMT originating from the muscularis propria layer remains challenging .…”

Section: Brief Explanationmentioning

confidence: 99%