School performance in adolescents with and without periventricular-intraventricular hemorrhage in the neonatal period

Bor, Margot van de; Ouden, Lya den

doi:10.1053/j.semperi.2004.08.007

Cited by 31 publications

(37 citation statements)

References 22 publications

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“…18 A population-based national study from the Netherlands involving preterm infants with a gestational age of ,32 weeks and/or a birth weight ,1500 g reported that the risk of needing special education for adolescents with grades I-II IVH increased twofold compared with those without IVH. 19 Lowe and colleagues in 1990 found that VLBW infants ,1501 g with grades I-II IVH performed less well at 5 to 6 years of age than at 1 to 2 years of age because specific visual motor and tactile perceptual skills are difficult to assess at 1 to 2 years of age. 20 The mechanism of brain injury in isolated grades I-II IVH during early gestation may result from impaired cortical development.…”

Section: Discussionmentioning

confidence: 99%

Intraventricular Hemorrhage and Neurodevelopmental Outcomes in Extreme Preterm Infants

et al. 2014

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OBJECTIVE: Not many large studies have reported the true impact of lower-grade intraventricular hemorrhages in preterm infants. We studied the neurodevelopmental outcomes of extremely preterm infants in relation to the severity of intraventricular hemorrhage. METHODS: A regional cohort study of infants born at 23 to 28 weeks’ gestation and admitted to a NICU between 1998 and 2004. Primary outcome measure was moderate to severe neurosensory impairment at 2 to 3 years’ corrected age defined as developmental delay (developmental quotient >2 SD below the mean), cerebral palsy, bilateral deafness, or bilateral blindness. RESULTS: Of the 1472 survivors assessed, infants with grade III–IV intraventricular hemorrhage (IVH; n = 93) had higher rates of developmental delay (17.5%), cerebral palsy (30%), deafness (8.6%), and blindness (2.2%). Grade I–II IVH infants (n = 336) also had increased rates of neurosensory impairment (22% vs 12.1%), developmental delay (7.8% vs 3.4%), cerebral palsy (10.4% vs 6.5%), and deafness (6.0% vs 2.3%) compared with the no IVH group (n = 1043). After exclusion of 40 infants with late ultrasound findings (periventricular leukomalacia, porencephaly, ventricular enlargement), isolated grade I–II IVH (n = 296) had increased rates of moderate-severe neurosensory impairment (18.6% vs 12.1%). Isolated grade I–II IVH was also independently associated with a higher risk of neurosensory impairment (adjusted odds ratio 1.73, 95% confidence interval 1.22–2.46). CONCLUSIONS: Grade I–II IVH, even with no documented white matter injury or other late ultrasound abnormalities, is associated with adverse neurodevelopmental outcomes in extremely preterm infants.

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Section: Discussionmentioning

confidence: 99%

Intraventricular Hemorrhage and Neurodevelopmental Outcomes in Extreme Preterm Infants

et al. 2014

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“…33,34,37,38,41 The lack of effect of mild PIVH on cognitive outcomes may truly be reflective of limited or no damage to the brain parenchyma. Data on short-term impact of PIVH on cognitive performance may also be limited because of the lack of studies specifically addressing it, along with the possibility of selection bias as described further shortly.…”

Section: Discussionmentioning

confidence: 99%

“…This process resulted in 20 studies deemed eligible for inclusion. [14][15][16]19,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Additionally, 1 study 43 was identified and deemed eligible through searching references of included studies, bringing the final total to 21. Baseline characteristics of the 21 included studies are as shown in Supplemental Information 2.…”

Section: Description Of Studiesmentioning

confidence: 99%

Periventricular/Intraventricular Hemorrhage and Neurodevelopmental Outcomes: A Meta-analysis

2015

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CONTEXT: Periventricular/intraventricular hemorrhage (PIVH) is a common short-term morbidity in preterm infants, but its long-term neurodevelopmental impact, particularly with mild PIVH, remains unclear. STUDY SELECTION: Studies reporting long-term neurodevelopmental outcomes based on severity of PIVH were included.DATA EXTRACTION: Study characteristics, inclusion/exclusion criteria, exposures, and outcome assessment data extracted independently by 2 coauthors. RESULTS:The pooled unadjusted odds ratios of the primary outcome of death or moderate-severe neurodevelopmental impairment (NDI) were higher with both mild (1.48, 95% CI 1.26-1.73; 2 studies) and severe PIVH (4.72, 4.21-5.31; 3 studies); no studies reported adjusted odds ratios. Among survivors, odds of moderate-severe NDI were higher with mild and severe PIVH in both unadjusted (1.75, 1.40-2.20; 3 studies; 3.36, 3.06-3.68; 5 studies) and adjusted (1.39, 1.09-1.77; 3 studies; 2.44, 1.73-3.42; 2 studies) pooled analyses. Adjusted odds of cerebral palsy and cognitive delay were higher with severe but not mild PIVH.LIMITATIONS: Only observational studies were included. Fifteen of 21 included studies had a moderate-high risk of bias.CONCLUSIONS: Mild and severe PIVH are associated with progressively higher odds of death or moderatesevere NDI compared with no PIVH, but no studies adjusted for confounders. Among survivors, mild PIVH was associated with higher odds of moderate-severe NDI compared with no PIVH.

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“…Infants with the mayor complications, like PVHI and PHH are at much higher risk of permanent neurologic impairments like cerebral palsy than dose with IVH alone (de Vries et al, 1999). More than 50% of children born before 32 weeks gestational age have school difficulties whether or not they had IVH, although the risk is clearly higher among children and adolescents with a story of IVH and lower birth gestational age or weight (Bowen et al, 2002;van de Bor & den Ouden, 2004). These cognitive or behavioural handicaps are related in part to white matter brain injury.…”

Section: Evolution and Prognosismentioning

confidence: 92%

Parenchymatous Brain Injury in Premature Infants: Intraventricular Hemorrhage and Periventricular Leukomalacia

Barría¹,

Flandez²

2012

Neonatal Care

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School performance in adolescents with and without periventricular-intraventricular hemorrhage in the neonatal period

Cited by 31 publications

References 22 publications

Intraventricular Hemorrhage and Neurodevelopmental Outcomes in Extreme Preterm Infants

Intraventricular Hemorrhage and Neurodevelopmental Outcomes in Extreme Preterm Infants

Periventricular/Intraventricular Hemorrhage and Neurodevelopmental Outcomes: A Meta-analysis

Parenchymatous Brain Injury in Premature Infants: Intraventricular Hemorrhage and Periventricular Leukomalacia

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