Periventricular/Intraventricular Hemorrhage and Neurodevelopmental Outcomes: A Meta-analysis

Mukerji, Amit; Shah, Vibhuti; Shah, Prakesh S.

doi:10.1542/peds.2015-0944

Cited by 259 publications

(250 citation statements)

References 47 publications

(52 reference statements)

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“…Segundo alguns estudos a HPIV grave associa-se a maior risco de sequelas no neurodesenvolvimento. 21,44 No presente estudo a HPIV grave não foi identificada como um fator de risco independente para défice moderado / grave do desenvolvimento. Neste estudo um perímetro craniano inferior ao P3 associou-se a um risco 5,7 vezes superior de sequela moderada / grave no neurodesenvolvimento.…”

Section: Resultsunclassified

“…Na literatura estão também estabelecidas associações entre a infeção e a lesão cerebral, incluindo hemorragia peri-intraventricular grave e leucomalácia periventricular. 21,22 A lesão da substância branca pode ser atribuída à lesão das células precursoras dos oligodendrócitos, que são sensíveis aos radicais livres e às citocinas inflamatórias geradas durante o episódio de sépsis. O reconhecimento da importância dos fatores ambientais tem levado à adoção de estratégias neuroprotetoras, como o programa NIDCAP (newborn individualized developmental care and assessment program), que visa reduzir o risco de exposição ao stress e, consequentemente, os seus efeitos deletérios no neurodesenvolvimento.…”

Section: -unclassified

“…48 21. Fez-se a análise descritiva dos dados para conhecer as características dos RN e avaliaram-se as taxas de mortalidade e a presença de sequelas por idade gestacional.…”

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Neurodesenvolvimento em Crianças Nascidas Pré-Termo de Muito Baixo Peso: Fatores de Risco Ambientais e Biológicos

Resende¹,

Martins²,

Faria³

et al. 2017

Acta Pediátrica Port

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Introdução: Pretendeu-se avaliar o neurodesenvolvimento em recém-nascidos pré-termo de muito baixo peso aos 24-30 meses de idade e correlacioná-lo com fatores de risco biológicos e ambientais. Métodos: Estudo observacional, retrospetivo de uma coorte de crianças nascidas entre janeiro de 2005 e dezembro de 2013, com idade gestacional inferior a 32 semanas e/ou peso de nascimento inferior a 1500 g numa maternidade de apoio perinatal diferenciado. Avaliou-se o neurodesenvolvimento aos 24-30 meses através da schedule of growing skills scales II. Considerou--se como existência de sequelas moderadas / graves a presença de paralisia cerebral, quociente de desenvolvimento global inferior a 70, cegueira ou surdez neurossensorial com necessidade de prótese auditiva. Analisaram-se, por regressão logística, os fatores de risco biológicos e ambientais associados significativamente à ocorrência de défice moderado / grave. Resultados: As 551 crianças estudadas apresentavam um peso de nascimento médio de 1222 ± 320 g e idade gestacional média de 29,4 ± 2,3 semanas. Ocorreram 46/551 óbitos (8%). Obteve-se informação do neurodesenvolvimento em 439/505 (87%) crianças. Apresentaram sequelas no neurodesenvolvimento 46/439 (10%): quociente de desenvolvimento global inferior a 70, 29/439 (7%), paralisia cerebral 26/439 (6%), surdez com necessidade de prótese auditiva 8/439 (2%) e um (0,2%) caso de cegueira. No modelo de regressão logística as variáveis que se associaram de modo significativo a sequelas moderadas / graves foram a leucomalácia periventricular quística, baixa escolaridade materna, perímetro craniano inferior ao percentil 3 aos 24-30 meses, malformações congénitas, crianças inseridas em família não convencional e sépsis tardia. Discussão: Fatores biológicos e ambientais são determinantes no neurodesenvolvimento, pelo que devem ser acionadas atempadamente medidas de intervenção nas crianças mais vulneráveis. Palavras-chave:Criança; Distúrbios do Neurodesenvolvimento; Fatores de Risco; Fatores Socioeconómicos; Recém-Nascido de Muito Baixo Peso; Recém-Nascido Prematuro Abstract Introduction: We aimed to assess neurodevelopment outcome in very low birth weight preterm newborns at 24-30 months of age and to correlate it with biological and environmental risk factors. Methods: In an observational case-cohort study of infants born between January 2005 and December 2013, with gestational age less than 32 weeks and/or birth weight less than 1500 g in a maternity hospital with specialised perinatal support, we assessed neurodevelopmental outcome at 24-30 months by means of the Schedule of Growing Skills II. Moderate/severe deficit was considered to be present if the child had cerebral palsy, overall Developmental Quotient less than 70, blindness or profound sensorineural deafness requiring hearing aids. Biological and environmental risk factors independently associated with the presence of moderate/severe deficit were analysed by logistic regression. Results: The 551 children studied had a mean birth weight and gestational age of ...

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Section: Resultsunclassified

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Neurodesenvolvimento em Crianças Nascidas Pré-Termo de Muito Baixo Peso: Fatores de Risco Ambientais e Biológicos

Resende¹,

Martins²,

Faria³

et al. 2017

Acta Pediátrica Port

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“…Neurodevelopmental injury remains a significant comorbidity for survivors of extreme prematurity and extremely low birth weight [47] . Prematurity-related brain injury, as seen with intraventricular and cerebellar hemorrhage, is highly associated with increased mortality, cerebral palsy, cognitive delay, behavioral anomalies, deafness, and blindness [48][49][50][51][52] . Despite the fact that a significant proportion of newborns with significant intraventricular hemorrhage will also go on to develop posthemorrhagic ventriculomegaly [53] , there is no consensus on the clinical management of these children [54] .…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid and Parenchymal Brain Development and Growth in the Healthy Fetus

Andescavage¹,

duPlessis

McCarter

et al. 2016

Dev Neurosci

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Objective: The objective of this study was to apply quantitative magnetic resonance imaging to characterize absolute cerebrospinal fluid (CSF) development, as well as its relative development to fetal brain parenchyma in the healthy human fetus. Design: We created three-dimensional high-resolution reconstructions of the developing brain for healthy fetuses between 18 and 40 weeks' gestation, segmented the parenchymal and CSF spaces, and calculated the volumes for the lateral, third, and fourth ventricles; extra-axial CSF space; and the cerebrum, cerebellum, and brainstem. From these data, we constructed normograms of the resulting volumes according to gestational age and described the relative development of CSF to fetal brain parenchyma. Results: Each CSF space demonstrated major increases in volumetric growth during the second half of gestation: third ventricle (23-fold), extra-axial CSF (11-fold), fourth ventricle (8-fold), and lateral ventricle (2-fold). Total CSF volume was related to total brain volume (p < 0.01), as was lateral ventricle to cerebral volume (p < 0.01); however, the fourth ventricle was not related to cerebellar or brainstem volume (p = 0.18-0.19). Relevance: Abnormalities of the CSF spaces are the most common anomalies of neurologic development detected on fetal screening using neurosonography. Normative values of absolute CSF volume, as well as relative growth in comparison to intracranial parenchyma, provide valuable insight into normal fetal neurodevelopment. These data may provide important biomarkers of early deviations from normal growth, better distinguish between benign variants and early disease, and serve as reference standards for postnatal growth and development in the premature infant.

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“…Los factores que contribuyen a predecir muerte y alteraciones del neurodesarrollo incluyen la severidad, la localización (bilateral vs unilateral) y presencia de infarto en parénquima derivado de la hemorragia (Mukerji, Shah & Shah, 2015). El riesgo de PC está claramente asociado con el grado de HIV (50% en HIV IV vs 8% en HIV I) (Wusthofff, 2016).…”

Section: Introductionunclassified

Factores Asociados a Hemorragia Intraventricular En Neonatos Atendidos En Un Hospital de Segundo Nivel

Camacho

Lira

Cortéz

et al. 2017

ESJ

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Intraventricular hemorrhage (HIV) is a complication in neonates. It originates in the subependymal germinal matrix. This area is irrigated by a network of poorly differentiated vessels without a basement membrane. Also, it is fragile and vulnerable to the hemodynamic instability of cerebral blood flow. It is an important risk factor for periventricular leukomalacia, ventriculomegaly, and hydrocephalus. These neurological pathologies can generate sequelae in the pediatric population such as cerebral palsy (CP). Objective: To identify the factors associated with HIV in neonates treated in the early intervention program of the hospital of specialties of the child and the woman of the Secretary of Health of the State of Querétaro (HENM-SESEQ). Material and Methods: Through the review of the clinical files, the factors associated with HIV present in the children attended to in the HENM-SESEQ early intervention service were observed in 2015. Cases of HIV were corroborated by means of transfontanel ultrasound, statistical analysis with measures of central tendency, and comparison of the medians of children diagnosed with HIV and without diagnosis. Results: A group of 69 infants attended to in the early intervention program was studied. Out of them, 65.2% (45) were women and 34.3% (24) were men. They had a gestational age of 34.19 ± 4.22 weeks, birth weight of 2116.09 ± 859.36 g, and height of 44.06 ± 6.02 cm. Their stay in the Neonatal Intensive Care Unit (NICU) for the sample was 11.88 ± 16.84 days and they were 8.65 ± 12.20 days with invasive mechanical ventilation. There were 25 cases of HIV diagnosed by

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Periventricular/Intraventricular Hemorrhage and Neurodevelopmental Outcomes: A Meta-analysis

Cited by 259 publications

References 47 publications

Neurodesenvolvimento em Crianças Nascidas Pré-Termo de Muito Baixo Peso: Fatores de Risco Ambientais e Biológicos

Neurodesenvolvimento em Crianças Nascidas Pré-Termo de Muito Baixo Peso: Fatores de Risco Ambientais e Biológicos

Cerebrospinal Fluid and Parenchymal Brain Development and Growth in the Healthy Fetus

Factores Asociados a Hemorragia Intraventricular En Neonatos Atendidos En Un Hospital de Segundo Nivel

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