School-based Study to Identify and Treat Adolescent Students at Risk for Tuberculosis Infection

Hatzenbuehler, Lindsay A.; Starke, Jeffrey R.; Graviss, Edward A.; Smith, E. OˈBrian; Cruz, Andrea T.

doi:10.1097/inf.0000000000001151

Cited by 12 publications

(14 citation statements)

References 17 publications

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“…Of the 19 included studies, 16 were partially or fully conducted in the U.S. 10,21–25,27–36 ; other locations included Canada, 10,22,34–36 Spain, 10,21,22,34–36 Taiwan, 26 Hong Kong, 21,35,36 Brazil, 10,12,22,33–35 Peru, 35 and South Africa (Appendix Table 2, available online). 11,21 The majority of studies targeted individuals aged ≥12 years, with three studies each focused exclusively on children and adolescents 23,25,36 and two focused on PLWHA. 11,35 Nine studies reported their funding source, with the majority of those being funded by NIH or Centers for Disease Control and Prevention.…”

Section: Evidence Synthesismentioning

confidence: 99%

Isoniazid-Rifapentine for Latent Tuberculosis Infection: A Systematic Review and Meta-analysis

Njie

Morris

Woodruff

et al. 2018

American Journal of Preventive Medicine

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Section: Evidence Synthesismentioning

confidence: 99%

Isoniazid-Rifapentine for Latent Tuberculosis Infection: A Systematic Review and Meta-analysis

Njie

Morris

Woodruff

et al. 2018

American Journal of Preventive Medicine

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“…For example in South Africa, 0.33% of new TB cases were detected among adolescent student screening [18]. In contrast, there was no active TB cases detected in either South Korea [19], Shanghai, China [20] nor the United States [21] among TB screening studies of 153, 1106 and 925 students, respectively. In the TB endemic area of Guangxi Zhuang Autonomous Region of China, there is no data on adolescent TB from households and schools versus the community.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis Transmission in Households and Classrooms of Adolescent Cases Compared to the Community in China

Pan

Lin

Lan

et al. 2018

IJERPH

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The aim of this paper is to evaluate the link between the history of exposure to tuberculosis (TB) in the household and diagnosed TB cases at school, and to compare the detection rate of active TB among household contacts and classroom contacts of adolescent TB cases with the rates among contacts of healthy controls. From November 2016 to December 2017, a prospective matched case-control study was conducted using passively identified index adolescent student cases from the TB surveillance system and healthy controls (matched by county, school type, sex, age and ethnicity). Contacts in households and classrooms of index cases and of controls were investigated. Matched tabulation of 117 case-control pairs revealed exposure to TB in the household as a strong risk factor (odds ratio (OR) = 21.0, 95% confidence interval (CI): 3.4, 868.6). Forty-five (case detection rate 0.69%) and two (case detection rate 0.03%) new active TB cases were detected among 6512 and 6480 classroom contacts of the index cases and controls, respectively. Having an index case in the classroom significantly increased the risk of classmates contracting active TB (OR = 22.5, 95% CI: 5.9, 191.4). Our findings suggested that previous exposure to TB in the household could lead a child to catch TB at school, then spread TB to classmates.

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“…The short-treatment duration makes administration during the academic school year feasible, and one study has shown that, with a preceding educational intervention, 35 children and their families are accepting of risk factor screening, testing, and treatment for TB infection through entirely school-based programs. 36 Such school-based programs provide an opportunity to identify children and adolescents who would otherwise not have access to care.…”

Section: Isoniazid and Rifapentine (3hp)mentioning

confidence: 99%

Treatment of Tuberculosis Infection in Children

Cruz

2017

J Pediatr Infect Dis

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The last decade has seen publication of more robust data for shorter course regimens for tuberculosis infection. These regimens are associated with higher completion rates than the traditional 6- to 9-month course of daily isoniazid (INH). These shorter regimens include 4 months of daily rifampin (RIF) and 12 once-weekly doses of INH and a long-acting rifamycin and rifapentine. In addition, a widely used regimen in the United Kingdom is 3 or 4 months of daily INH and RIF. All regimens have demonstrated efficacy in the ideal conditions of clinical studies, and all have very low rates of hepatotoxicity in children. These newer regimens likely are more effective than longer courses of INH once patient and family adherence is considered. Clinicians need to be cognizant of poor completion rates with traditional INH therapy and how the use of rifamycin-containing regimens offers more palatable options for children and their families.

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School-based Study to Identify and Treat Adolescent Students at Risk for Tuberculosis Infection

Abstract: School-based TB education, screening, testing using IGRAs and administration of 3HP treatment is feasible to improve the identification and treatment of adolescent students at risk for TB.

Cited by 12 publications

References 17 publications

Isoniazid-Rifapentine for Latent Tuberculosis Infection: A Systematic Review and Meta-analysis

Isoniazid-Rifapentine for Latent Tuberculosis Infection: A Systematic Review and Meta-analysis

Tuberculosis Transmission in Households and Classrooms of Adolescent Cases Compared to the Community in China

Treatment of Tuberculosis Infection in Children

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