Schlafentzug und anschließende Schlafphasenvorverlagerung stabilisiert den positiven Schlafentzugseffekt bei depressiven Episoden

Albert, Rossina Rossi; Merz, A.; Schubert, Johannes; Ebert, Dieter

doi:10.1007/s001150050240

Cited by 22 publications

(4 citation statements)

References 10 publications

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“…It has been shown that approximately two thirds of the patients who react positively to total sleep deprivation (at least 30% reduction of 6-item Hamilton Depression Scale scores) can be maintained in a positive mood state for 1 week [Vollmann and Berger, 1993;Berger et al, 1997;Riemann et al, 1999]. These results have been confirmed by other groups [Albert et al, 1998;Benedetti et al, in press].…”

Section: Sleep and Sleep Phase Advance In Bipolar Depressionsupporting

confidence: 80%

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Riemann

Voderholzer

Berger³

2002

Neuropsychobiology

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In the last 30 years, it has been convincingly demonstrated that sleep in major depression is characterized by disturbances of sleep continuity, a reduction of slow wave sleep, a disinhibition of REM sleep including a shortening of REM latency (i.e. the time between sleep onset and the occurrence of the first REM period) and an increase in REM density. Furthermore, manipulations of the sleep-wake cycle like total or partial sleep deprivation or phase advance of the sleep period have been proven to be effective therapeutic strategies for patients with unipolar depression. The database concerning sleep and sleep-wake manipulations in bipolar disorder in comparison is not yet as extensive. Studies investigating sleep in bipolar depression suggest that during the depressed phase sleep shows the same stigmata as in unipolar depression. During the hypomanic or manic phase, sleep is even more curtailed, though subjectively not experienced as disturbing by the patients. REM sleep disinhibition is present as well. An important issue is the question, whether sleep-wake manipulations can also be applied in patients with bipolar depression. Work by others and our own studies indicate that sleep deprivation and a phase advance of the sleep period can be used to treat bipolar patients during the depressed phase. The risk of a switch into hypomania or mania does not seem to be more pronounced than the risk with typical pharmacological antidepressant treatment. For patients with mania, sleep deprivation is not an adequate treatment – in contrast, treatment strategies aiming at stabilizing a regular sleep-wake schedule are indicated.

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Section: Sleep and Sleep Phase Advance In Bipolar Depressionsupporting

confidence: 80%

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Riemann

Voderholzer

Berger³

2002

Neuropsychobiology

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“…Surprisingly, the response rates with a 3-days advance protocol were similar to those in earlier studies using a 6-days phase advance treatment after SD (Vollmann & , Berger et al 1997,Albert et al 1998, Riemann et al 1999). This is in agreement with a recent study by Benedetti and coworkers (2001) who investigated 30 depressive patients with SD and consecutive 3days phase advance and found that phase advance was able to sustain the antidepressant effect of SD.…”

Section: Discussionsupporting

confidence: 84%

“…It has been shown in several clinical trials that a "phase advance"of the sleep period after SD can prevent relapses in about 60 % of responders to SD (Souetre et al 1987, Vollmann & Berger 1993, Riemann et al 1996, Berger et al 1997, Albert et al 1998). The rationale behind the combination of SD with a consecutive phase advance is based on studies comparing partial SD during the first and the second half of the night (Wehr 1990 for overview) and on "nap" studies after SD in depressives (Wiegand et al 1987, Riemann et al 1993).…”

mentioning

confidence: 99%

Is the antidepressive effect of sleep deprivation stabilized by a three day phase advance of the sleep period?

Voderholzer¹,

Valerius²,

Schaerer³

et al. 2003

European Archives of Psychiatry and Clinical Neurosciences

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“…The advanced sleep phase was then shifted to the normal phase position within 1 week. It was shown in several studies that this combined sleep deprivation and sleep phase advance therapy was able to maintain the positive effect of sleep deprivation in about 60–75% of the sleep deprivation responders (74–78), compared with a 40% response rate in a control condition (‘phase delay’) (see Fig. 6).…”

Section: Other Manipulations Of the Sleep–wake Cyclementioning

confidence: 93%

Sleep and manipulations of the sleep–wake rhythm in depression

Berger

Calker

Riemann

2003

Acta Psychiatr Scand

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Objective: Disturbed sleep is typical for most depressed patients and complaints about disordered sleep are the hallmarks of the disorder. Polysomnographic sleep research has demonstrated that besides impaired sleep continuity, sleep in depression is characterized by a reduction of slow wave sleep and a disinhibition of random eye movement (REM) sleep, with a shortening of REM latency, a prolongation of the first REM period and increased REM density. Method: Our own experimental work has focused on the reciprocal interaction hypothesis of non‐REM and REM sleep regulation as a model to explain the characteristic features of depressed sleep. Results: In agreement with the major tenet of this model, administration of cholinomimetics provoked shortened REM latency in healthy subjects and led to an even stronger REM sleep disinhibition in depressed patients. Manipulations of the sleep–wake cycle, such as sleep deprivation or a phase advance of the sleep period, alleviate depressive symptoms. Conclusion: These data indicate a strong bidirectional relationship between sleep, sleep alterations and depression.

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Schlafentzug und anschließende Schlafphasenvorverlagerung stabilisiert den positiven Schlafentzugseffekt bei depressiven Episoden

Cited by 22 publications

References 10 publications

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Is the antidepressive effect of sleep deprivation stabilized by a three day phase advance of the sleep period?

Sleep and manipulations of the sleep–wake rhythm in depression

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