Is the antidepressive effect of sleep deprivation stabilized by a three day phase advance of the sleep period?

Voderholzer, Ulrich; Valerius, Gabriele; Schaerer, Lars; Riemann, Dieter; Giedke, H.; Schwärzler, Frank; Berger, Thomas; Wiegand, M.

doi:10.1007/s00406-003-0408-7

Cited by 53 publications

(12 citation statements)

References 28 publications

(16 reference statements)

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“…For this latter combination, a phase advance of the sleep–wake cycle and of the rest–activity rhythms is a correlate of antidepressant response to SD (Benedetti, Dallaspezia, Fulgosi, et al., ). The efficacy of the triple combination of SD, LT and sleep phase advance has been tested in multiple clinical settings and ethnic groups, with consistently replicated antidepressant effects and similar effect sizes (Benedetti, Barbini, et al., ; Berger et al., ; Echizenya, Suda, Takeshima, Inomata, & Shimizu, ; Gottlieb & Terman, ; Hurd, Herrera, Brant, Coombs, & Arzubi, ; Sahlem et al., ; Voderholzer et al., ; Wu et al., ).…”

Section: Where Are We Today?mentioning

confidence: 95%

Perspectives in affective disorders: Clocks and sleep

Wirz‐Justice

Benedetti

2019

Eur J of Neuroscience

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Mood disorders are often characterised by alterations in circadian rhythms, sleep disturbances and seasonal exacerbation. Conversely, chronobiological treatments utilise zeitgebers for circadian rhythms such as light to improve mood and stabilise sleep, and manipulations of sleep timing and duration as rapid antidepressant modalities. Although sleep deprivation (“wake therapy”) can act within hours, and its mood‐elevating effects be maintained by regular morning light administration/medication/earlier sleep, it has not entered the regular guidelines for treating affective disorders as a first‐line treatment. The hindrances to using chronotherapeutics may lie in their lack of patentability, few sponsors to carry out large multi‐centre trials, non‐reimbursement by medical insurance and their perceived difficulty or exotic “alternative” nature. Future use can be promoted by new technology (single‐sample phase measurements, phone apps, movement and sleep trackers) that provides ambulatory documentation over long periods and feedback to therapist and patient. Light combinations with cognitive behavioural therapy and sleep hygiene practice may speed up and also maintain response. The urgent need for new antidepressants should hopefully lead to reconsideration and implementation of these non‐pharmacological methods, as well as further clinical trials. We review the putative neurochemical mechanisms underlying the antidepressant effect of sleep deprivation and light therapy, and current knowledge linking clocks and sleep with affective disorders: neurotransmitter switching, stress and cortico‐limbic reactivity, clock genes, cortical neuroplasticity, connectomics and neuroinflammation. Despite the complexity of multi‐system mechanisms, more insight will lead to fine tuning and better application of circadian and sleep‐related treatments of depression.

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Section: Where Are We Today?mentioning

confidence: 95%

Perspectives in affective disorders: Clocks and sleep

Wirz‐Justice

Benedetti

2019

Eur J of Neuroscience

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“…Nevertheless, most studies focusing on sleep disorders have avoided enrolling females, overlooked sex and gender effects, or applied suboptimal methodology [4]. In addition, sleep research has previously applied findings from adults to adolescents, disregarding the discrete developmental processes of adolescence, and ignoring etiological and behavioral differences [5]. For instance, for most adults, sleep length highly depends on demand of work, accomplishing the tasks needed to keep a household functioning, and fulfilling parental obligations, which are not largely applicable to adolescents.…”

Section: Introductionmentioning

confidence: 99%

“…Analogous pediatric studies have shown mixed results, with some researchers indicating that sex/gender has no influence on sleep, while others argue for significant disparities in prevalence and outcomes [5][6][7][8]. Discordance could be due to over reporting in national surveys, (representative of the national population, but lacking objective measures), or convenience sampling (recruiting patients in sleep centers).…”

Section: Introductionmentioning

confidence: 99%

Disparities in Sleep Health among Adolescents: The Role of Sex, Age, and Migration

2020

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Background. Disparities in sleep disturbances have been described in adults; nevertheless, among adolescents, data have yielded conflicting results. Therefore, analyses of our cohort study of 500 urban, normally developed Hispanic adolescents (10–18 years), aim to determine if rates of sleep debt differ between: (a) male and female adolescents, (b) US-born Hispanics and first-generation immigrant ethnic counterparts, and (c) specific activities that these teens trade for sleep. Participants’ weekday and weekend sleep patterns, along with the reasons for sleeping less than the recommended hours were recorded. Standardized surveys were used to gather information regarding sociodemographics, migration, acculturation, and medical history. Using the criteria set forth by the National Sleep Foundation, analyses indicated that sleep deprivation is a pervasive problem, with 75% in the preadolescents and 45% of the late adolescents exhibiting sleep problems. Females slept on average at least one hour less per day than their male counterparts (7 vs. 8 hours). The sleep problems were rooted in several overlapping causes, including use of technology, video games, studying, and employment. Nevertheless, reasons for sleep loss differed by gender and by immigrant status. Multivariable adjusted logistic regression analyses showed that females, US-born teens, and preadolescents had higher odds of being sleep deprived. Pediatricians and sleep experts should be aware of gender-specific causes and responses of sleep problems. Cultural ecological frameworks need to be considered, and clearly indicate that findings may not generalize to youth from other cultural backgrounds.

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“…Furthermore, patients with depression are prone to drift to later sleep schedules 3. We should thus expect that dynamic lighting with enriched short-wavelength morning light and low content short-wavelength light in the evening would prevent drifting or even phase advance the sleep-wake cycle and thus augment the antidepressant treatment response 28…”

Section: Introductionmentioning

confidence: 99%

Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

et al. 2020

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IntroductionRetrospective studies conducted in psychiatric inpatient wards have shown a relation between the intensity of daylight in patient rooms and the length of stay, pointing to an antidepressant effect of ambient lighting conditions. Light therapy has shown a promising antidepressant effect when administered from a light box. The emergence of light-emitting diode (LED) technology has made it possible to build luminaires into rooms and to dynamically mimic the spectral and temporal distribution of daylight. The objective of this study is to investigate the antidepressant efficacy of a newly developed dynamic LED-lighting system installed in an inpatient ward.Methods and analysisIn all, 150 inpatients with a major depressive episode, as part of either a major depressive disorder or as part of a bipolar disorder, will be included. The design is a two-arm 1:1 randomised study with a dynamic LED-lighting arm and a static LED-lighting arm, both as add-on to usual treatment in an inpatient psychiatric ward. The primary outcome is the baseline adjusted score on the 6-item Hamilton Depression Rating Scale at week 3. The secondary outcomes are the mean score on the Suicidal Ideation Attributes Scale at week 3, the mean score on the 17-item Hamilton Depression Rating Scale at week 3 and the mean score on the World Health Organisation Quality of Life-BREF (WHOQOL-BREF) at week 3. The spectral distribution of daylight and LED-light, with a specific focus on light mediated through the intrinsically photosensitive retinal ganglion cells, will be measured. Use of light luminaires will be logged. Assessors of Hamilton Depression Rating Scale scores and data analysts will be blinded for treatment allocation. The study was initiated in May 2019 and will end in December 2021.Ethics and disseminationNo ethical issues are expected. Results will be published in peer-reviewed journals, disseminated electronically and in print and presented at symposia.Trial registration numberNCT03821506; Pre-results.

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Is the antidepressive effect of sleep deprivation stabilized by a three day phase advance of the sleep period?

Cited by 53 publications

References 28 publications

Perspectives in affective disorders: Clocks and sleep

Perspectives in affective disorders: Clocks and sleep

Disparities in Sleep Health among Adolescents: The Role of Sex, Age, and Migration

Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

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