Schizophyllum commune β-glucan: Effect on interleukin-10 expression induced by lipopolysaccharide from periodontopathic bacteria

Thongsiri, Chuencheewit; Nagai‐Yoshioka, Yoshie; Yamasaki, Ryota; Adachi, Yoshiyuki; Usui, Michihiko; Nakashima, Keisuke; Nishihara, Tatsuji; Ariyoshi, Wataru

doi:10.1016/j.carbpol.2020.117285

Cited by 20 publications

(17 citation statements)

References 46 publications

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“…β-Glucans can bind to specific receptors to activate macrophages, dendritic cells, neutrophils, and monocytes, and stimulate humoral and cellular immunity. As a result, by launching various signaling cascades, in addition to strengthening the immune system, they also stimulate it to fight cancer [ 53 – 55 ]. The anti-cancer activity of H. erinaceus polysaccharides was shown on human liver cancer (Hep G2), human breast cancer (MCF-7), and colon cancer (HCT 116) cells [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity and cytotoxicity of exopolysaccharide from mushroom Hericium coralloides in submerged fermentation

Tabibzadeh

Alvandi

Hatamian-Zarmi

et al. 2022

Biomass Conv. Bioref.

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Mushrooms of the genus Hericium spp. represent a series of delicious edible mushrooms with medicinal value. Here, for the first time, the species native to Iran, the mushroom Hericium coralloides , was collected in Mazandaran province, identified, and registered with the NCBI under accession number MW136052. The production of exopolysaccharides (EPS) in submerged culture was optimized using the response surface method. Among the physicochemical and culture medium conditions tested, rotation speed and concentration of maltose and peptone of soybean significantly affected the production of EPS. The proposed model predicts maximum EPS production (0.13 g/L) at 50 g/L maltose, 3 g/L soy peptone, and 1 g/L yeast extract, pH = 6.5, 200 rpm, inoculum at 5% v/v, and 22 °C. The molecular weight of the EPS chains was 413 and 1578 Da. EPS has antioxidant action (EC50 = 6.59 mg/mL) and cytotoxic activity against cancer cells. The viability of AGS and MKN-45 cancer cell lines declined to 20 and 30% after 48 h of the EPS treatment. H. coralloides EPS could be considered a natural dietary anti-cancer supplement. Further studies are necessary to understand the mechanism of the H. coralloides EPS activity on the cell cycle of cancer cells and to prove its action in vivo. Supplementary Information The online version contains supplementary material available at 10.1007/s13399-022-03386-0.

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity and cytotoxicity of exopolysaccharide from mushroom Hericium coralloides in submerged fermentation

Tabibzadeh

Alvandi

Hatamian-Zarmi

et al. 2022

Biomass Conv. Bioref.

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“…The properties of schizophyllan depend on several factors, including the monosaccharide composition, molecular weight, and water solubility; the extraction methods strongly influence these physicochemical properties [58]. Recent studies have shown that schizophyllan enhances the anti-inflammatory response in mouse macrophages, which may be useful in the formation of inferences during inflammatory diseases such as periodontal disease [59]. Schizophyllan has the ability to Recent studies have shown that schizophyllan enhances the anti-inflammatory response in mouse macrophages, which may be useful in the formation of inferences during inflammatory diseases such as periodontal disease [59].…”

Section: Schizophyllanmentioning

confidence: 99%

“…Recent studies have shown that schizophyllan enhances the anti-inflammatory response in mouse macrophages, which may be useful in the formation of inferences during inflammatory diseases such as periodontal disease [59]. Schizophyllan has the ability to Recent studies have shown that schizophyllan enhances the anti-inflammatory response in mouse macrophages, which may be useful in the formation of inferences during inflammatory diseases such as periodontal disease [59]. Schizophyllan has the ability to activate the dectin-1 receptor, which contributes to the increased secretion of pro-inflammatory cytokines, but at the same time strongly promotes the production of IL-10, a key antiinflammatory cytokine that plays an important role in controlling inflammation [59].…”

Section: Schizophyllanmentioning

confidence: 99%

“…Krestin also shows immune-boosting and antiviral properties and hypocholesterolemic and prebiotic activity [40,62]. Recent studies have shown that schizophyllan enhances the anti-inflammator sponse in mouse macrophages, which may be useful in the formation of inferences du inflammatory diseases such as periodontal disease [59]. Schizophyllan has the abil activate the dectin-1 receptor, which contributes to the increased secretion of pro-in matory cytokines, but at the same time strongly promotes the production of IL-10, anti-inflammatory cytokine that plays an important role in controlling inflammation 2.2.3.…”

Section: Krestinmentioning

confidence: 99%

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Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era

Mirończuk-Chodakowska

Kujawowicz

Witkowska

2021

Nutrients

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Beta-glucans comprise a group of polysaccharides of natural origin found in bacteria, algae, and plants, e.g., cereal seeds, as well as microfungi and macrofungi (mushrooms), which are characterized by diverse structures and functions. They are known for their metabolic and immunomodulatory properties, including anticancer, antibacterial, and antiviral. Recent reports suggest a potential of beta-glucans in the prevention and treatment of COVID-19. In contrast to β-glucans from other sources, β-glucans from mushrooms are characterized by β-1,3-glucans with short β-1,6-side chains. This structure is recognized by receptors located on the surface of immune cells; thus, mushroom β-glucans have specific immunomodulatory properties and gained BRM (biological response modifier) status. Moreover, mushroom beta-glucans also owe their properties to the formation of triple helix conformation, which is one of the key factors influencing the bioactivity of mushroom beta-glucans. This review summarizes the latest findings on biological and health-promoting potential of mushroom beta-glucans for the treatment of civilization and viral diseases, with particular emphasis on COVID-19.

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“…In connection with biological activity, schizophyllan has an anti-tumor activity at the triple helical conformation, which is closely related with innate and adaptive immune responses. For instance, Dectin-1 is one of the β-1,3-glucan receptors, which exists on the cell membrane of the murine and human leukocytes to exert innate immunity. , Trp221 and His223 in the carbohydrate-recognition domain of Dectin-1 are concerned crucially with the pattern recognition with the triple helix of β-1,3- d -glucans. − In this study, imidazole was selected as an additive to investigate the solvent effects of the CODT of schizophyllan. Imidazole is a pendant group of histidine, which is an important amino acid of Dectin-1 essential for the innate activity.…”

Section: Introductionmentioning

confidence: 99%

Association with Imidazole in the Cooperative Order–Disorder Transition in Aqueous Solution of Schizophyllan

et al. 2022

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Schizophyllan, a triple helical polysaccharide, exhibits cooperative order−disorder transition (CODT) in aqueous solutions. The transition transforms the ordered structure (triple helix I) formed between the branched side chains and solvent molecules into the disordered structure (triple helix II) without dissociation of the triple helix. The CODT behaviors in H 2 O−imidazole mixtures containing HCl with different molar ratios of imidazole/HCl were investigated by adiabatic calorimetry and differential scanning calorimetry on two schizophyllan solutions with different molar masses. The transition temperature (T r ) and the transition enthalpy (ΔH r ) significantly depended on both of the mole fractions of imidazole and imidazole/HCl. The composition dependences of T r and ΔH r in H 2 O−imidazole mixtures were analyzed with linear cooperative transition theory for the solvent-stabilizing effect in the mixture with active compounds. Theoretical analyses confirmed that both imidazole and imidazolium ions in the solutions competitively interact with the side chain of the triple helix.

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Schizophyllum commune β-glucan: Effect on interleukin-10 expression induced by lipopolysaccharide from periodontopathic bacteria

Cited by 20 publications

References 46 publications

Antioxidant activity and cytotoxicity of exopolysaccharide from mushroom Hericium coralloides in submerged fermentation

Antioxidant activity and cytotoxicity of exopolysaccharide from mushroom Hericium coralloides in submerged fermentation

Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era

Association with Imidazole in the Cooperative Order–Disorder Transition in Aqueous Solution of Schizophyllan

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