Schizencephaly: Dramatic Images in a Normally Functioning Adult

Abstract

A 47-year-old man presented after he had a witnessed tonic-clonic seizure while standing on the street. Since childhood he had a history of "cerebral palsy," and after a motor vehicle accident he had leftsided weakness and seizures that began only a month before presentation to us. The patient had been taking levetiracetam but had been noncompliant with this medication for a week prior to the episode of seizure that occurred on the street. After this seizure, he had worsened left-sided weakness. Previous seizures were notable for ensuing extended Todd's paralysis lasting more than a day. Prior to presentation the patient was living alone, independent with activities of daily living and ambulation, and worked as a restaurant cook. Examination revealed that the patient had normal cognition and speech but significant left-side weakness with increased tone and shortened limbs.

A Patient with Schizencephaly and Agenesis of Corpus Callosum with No Neurological Deficits

“…A number of similar cases have been previously reported,[ 3 4 ] but all exhibit certain degrees of central nervous system manifestations such as cerebral palsy and epilepsy which are absent in this patient. This case demonstrates that it is possible for a patient to have schizencephaly along with partial agenesis of the corpus callosum and be without neurological deficits.…”

Bilateral schizencephaly in a preterm newborn

“…Schizencefalie se vyskytuje unilaterálně i bilaterálně, často bývá asociovaná s dalšími malformacemi CNS nebo s některými komplexními syndromy. Výsledný klinický obraz je velmi variabilní, popisované spektrum postižení ve většině případů představuje závažný motorický deficit, mentální retardaci a epilepsii, ale může se jednat i o mírnější projevy diagnostikované až v dospělosti (2,3,4,5). Schizencefalie je většinou prokázána magnetickou rezonancí (MRI) v rámci komplexní diagnostiky psychomotorické retardace, abnormálního neurologického nálezu nebo epilepsie v dětství.…”