Schistosomiasis und Siegelringzellkarzinom der Ileozökalklappe

Helmstädter, V.; Ostertag-Körner, D.; Wysocki, S; R, Waldherr

doi:10.1055/s-2008-1058695

Cited by 5 publications

(2 citation statements)

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“…The overall examination of the specimen showed an ulcerated tumour, S. mansoni ova in a cancerous tumour and colonic submucosa, where eggs were seen more in tumour tissue than in normal tissue. This case is consistent with the conditions of the infection, whereby intestinal Schistosomiasis induces various pathologic conditions, including carcinoma [11,15,17,42,45,46], lymphoma [15,47] polyps [17,48,49], carcinoid [43] and pedunculated teratoma [43].…”

Section: Pathological Evidencesupporting

confidence: 80%

“…The changes of dysplastic are considered as the pathological basis for the malignant probability of Schistosomal colitis and these changes are found in long-term ulcerative colitis [11,41]. Chronic intestinal Schistosomiasis is noted as potentially a pre-cancerous condition [42,43] and many investigators believe that the mechanism of injury caused by Schistosoma is due to the endogenous production of toxins by eggs rather than a direct carcinogenic action of the eggs [43]. On the other hand, Matsuda believed that Schistosomal ova also displayed some effects on carcinogenesis [17,44].…”

Section: Pathological Evidencementioning

confidence: 99%

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A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis

Abdalkareem¹,

Yin²

2019

TOIDJ

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Background: Schistosomiasis is one of the parasitic infections that are often found in humans. More than approximately 200 million people are infected with Schistosomiasis in tropical and subtropical areas of Africa, South America and Asian countries. Literature has long been suggesting the correlation between Schistosomiasis and colorectal malignancy. There is a considerable directory supporting the etiological relation between Schistosoma japonicum infection and colorectal cancer in the Far East, however, the available data about the role of Schistosoma mansoni that can initiate the carcinogenesis of colorectal remain insignificant. Objective: As such, more studies of this disease should be conducted comprehensively for corporate social responsibility internationally. Methods: The present study reviewed the available data about the role of Schistosoma, including S. mansoni in association with the carcinogenesis of colorectal. Results: The study shows the possible evidence of epidemiology, pathology, molecules and immunopathology associated with Schistosomal infections and colorectal cancer. The infections are apparently getting little attention nor support worldwide due to the geographical barriers and some political issues because it mainly occurs in the people living in the bottom billion and happens in the endemic regions only. Conclusion: The in-depth study of this infectious disease will tailor early diagnosis, novel prescription drugs and cost-effective strategies for the treatment of infectious disease colorectal cancer, and hence eradicate the disease in the endemic regions.

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Section: Pathological Evidencesupporting

confidence: 80%

Section: Pathological Evidencementioning

confidence: 99%

A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis

Abdalkareem¹,

Yin²

2019

TOIDJ

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Primary signet-ring cell carcinoma of the ileum: report of two cases

Reyes¹

2009

Community Oncology

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The ‘wandering’ abdominal lump: intussusception up to splenic flexure of an ileocaecal adenocarcinoma

et al. 2005

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A63-year old woman presented with a 4-day history of watery diarrhoea that was preceded by acute constipation. This was associated with intermittent colicky abdominal pain and one episode of fresh rectal bleeding on the previous day. Past history included haemorrhoids, cholecystectomy and reflux disease with no significant family history of cancer. She was seen in the accident and emergency department with a mass in right iliac fossa (RIF), which was managed as scabylous mass owing to the history of constipation. The next day, the woman came back with continued symptoms. On this occasion, she had a firm, mobile mass, now palpable in the left hypochondrium associated with abdominal distension. Rectal examination revealed an empty rectum. Haematological and biochemical tests including tumour markers were essentially normal. Plain X-ray of the abdomen revealed a partial small bowel obstruction and the patient was commenced on conservative management. The following day, although her symptoms resolved, the mobile abdominal mass was still persistent but now palpable in the RIF. An ultrasound examination of the abdomen and pelvis showed ‘a pseudo-kidney’ sign in the RIF (Figure 1). An unprepared contrast enema revealed a possible neoplastic lesion at the splenic flexure (Figure 2). Helical computed tomography showed a ‘bowel within bowel’ appearance in the left hypochondrium with proximally-dilated small bowel loops (Figure 3). She underwent a laparotomy, which showed a mobile, ileocaecal tumour with intussusception reaching the splenic flexure. There was no evidence of disseminated disease. An extended right hemicolectomy with en-bloc resection of the intussuscepting mass was performed. She had an uneventful postoperative period. Pathological examination of the resected specimen revealed a 4.0 cm × 4.5 cm × 3.0 cm nodular tumour of the ileocaecal valve with intussusception of a 6.0 cm length of terminal ileum. Histological examination showed a moderately well differentiated adenocarcinoma with clear resection margins (Figure 4). There was no nodal or vascular invasion. Pathological staging of the tumour was Dukes' A, T2 (tumor confined to bowel wall), N0 (no tumor deposit in 11 lymph node harvested) (0/11), M0 (no distance metastasis).

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Schistosomiasis und Siegelringzellkarzinom der Ileozökalklappe

Cited by 5 publications

References 0 publications

A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis

A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis

Primary signet-ring cell carcinoma of the ileum: report of two cases

The ‘wandering’ abdominal lump: intussusception up to splenic flexure of an ileocaecal adenocarcinoma

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