Background: Schistosomiasis is one of the parasitic infections that are often found in humans. More than approximately 200 million people are infected with Schistosomiasis in tropical and subtropical areas of Africa, South America and Asian countries. Literature has long been suggesting the correlation between Schistosomiasis and colorectal malignancy. There is a considerable directory supporting the etiological relation between Schistosoma japonicum infection and colorectal cancer in the Far East, however, the available data about the role of Schistosoma mansoni that can initiate the carcinogenesis of colorectal remain insignificant. Objective: As such, more studies of this disease should be conducted comprehensively for corporate social responsibility internationally. Methods: The present study reviewed the available data about the role of Schistosoma, including S. mansoni in association with the carcinogenesis of colorectal. Results: The study shows the possible evidence of epidemiology, pathology, molecules and immunopathology associated with Schistosomal infections and colorectal cancer. The infections are apparently getting little attention nor support worldwide due to the geographical barriers and some political issues because it mainly occurs in the people living in the bottom billion and happens in the endemic regions only. Conclusion: The in-depth study of this infectious disease will tailor early diagnosis, novel prescription drugs and cost-effective strategies for the treatment of infectious disease colorectal cancer, and hence eradicate the disease in the endemic regions.

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Abstract-D6, which is also known as CCBP 2, is one of the decoy chemokine receptors. It was recently found to play a role in the progression of breast cancer cells. In this study, the existence of D6 in invasive breast cancer cells, MDA-MB-231 was investigated by One-step RT-PCR with additional Pfu DNA polymerase in the reaction. The amplicons were then sequenced and compared with the reference sequence from GenBank database. Nucleotide sequence analysis showed that the amplicon sequence matches the reference sequence. Thus, it is confirmed that full length D6 sequence had been amplified from MDA-MB-231.Index Terms-Cloning, D6, DNA sequencing, MDA-MB-231.