Schistosomiasis mansoni: follow-up of control program based on parasitologic and serologic methods in a Brazilian community of low endemicity

Burlandy-Soares, Lanny Cristina; Dias, Luiz Cândido de Souza; Kanamura, Hermínia Yohko; Oliveira, Edward; Ciaravolo, Ricardo Mário de Carvalho

doi:10.1590/s0074-02762003000600025

Cited by 21 publications

(13 citation statements)

References 14 publications

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“…The reaction between parasite antigens and antischistosomal antibodies in patient serum or other bodily fluids is the concept behind the IFA, which is performed using adult worm paraffin sections, cercariae, and eggs (120)(121)(122). IFA detection of IgM and IgG antibodies in the acute and chronic stages of schistosomiasis has been used as a sensitive method of diagnosis, especially in low-prevalence areas (90,123,125), in some instances combined with other diagnostic procedures to increase the sensitivity and specificity (111,126). Some limitations of the test, including the need for relatively expensive microscopes and reagents, with appropriate laboratory facilities and technical expertise, hinder its application in community surveys (123,125).…”

Section: Antibody Detectionmentioning

confidence: 99%

Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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SUMMARY Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.

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Section: Antibody Detectionmentioning

confidence: 99%

Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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“…The specificity of this reaction has also proved to be adequate. 15,16 The periovular reaction has a high sensitivity and specificity for the detection of antibodies against the secretion or excretion antigens of viable Schistosoma mansoni eggs. 4,13,17,18 Although it is a very laborious technique, it is the only antibody detection technique that has been shown to correlate with parasite activity.…”

Section: Introductionmentioning

confidence: 99%

Detection of Schistosoma mansoni Antibodies in a Low-Endemicity Area Using Indirect Immunofluorescence and Circumoval Precipitin Test

Espírito-Santo

Pintó

Gargioni

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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Abstract. Parasitological diagnostic methods for schistosomiasis lack sensitivity, especially in regions of low endemicity. The objective of this study was to determine the prevalence of Schistosoma mansoni infections by antibody detection using the indirect immunofluorescence assay (IFA-IgM) and circumoval precipitin test (COPT). Serum samples of 572 individuals were randomly selected. The IFA-IgM and COPT were used to detect anti-S. mansoni antibodies. Of the patients studied, 15.9% (N = 91) were IFA-IgM positive and 5.1% (N = 29) had COPT reactions (P 0.001 by McNemar's test). Immunodiagnostic techniques showed higher infection prevalence than had been previously estimated. This study suggests that combined use of these diagnostic tools could be useful for the diagnosis of schistosomiasis in epidemiological studies in areas of low endemicity.

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“…Of these, 16 (6%) had positive results in stool examination in the first sample batch [26] . Burlandy et al reported that the high difference between serologic and parasitologic prevalence data is undoubtedly due to the low diagnostic sensitivity of the parasitologic methods [27] . Therefore, microscopical method is not satisfied, especially when the number of worms is low or the test is done after the eggs were eliminated from the body [6] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of microscopical and serological techniques in the diagnosis of Schistosoma mansoni infection at Sennar State, Central Sudan

Ibrahim

2014

Asian Pacific Journal of Tropical Disease

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Schistosomiasis mansoni: follow-up of control program based on parasitologic and serologic methods in a Brazilian community of low endemicity

Cited by 21 publications

References 14 publications

Advances in the Diagnosis of Human Schistosomiasis

Advances in the Diagnosis of Human Schistosomiasis

Detection of Schistosoma mansoni Antibodies in a Low-Endemicity Area Using Indirect Immunofluorescence and Circumoval Precipitin Test

Evaluation of microscopical and serological techniques in the diagnosis of Schistosoma mansoni infection at Sennar State, Central Sudan

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