Evaluation of microscopical and serological techniques in the diagnosis of Schistosoma mansoni infection at Sennar State, Central Sudan

Ibrahim, A. M.; Ibrahim, Mohamed T.

doi:10.1016/s2222-1808(14)60305-4

Cited by 3 publications

(5 citation statements)

References 28 publications

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“…This area is located beside sugar factory and surrounded with canals and creeks to irrigate the sugar cane scheme. Infection with intestinal schistosomiasis is dominant in this area with a prevalence rate of 27% [4]. The study area is comprised of four villages, each village's populations range between 3400-4600 inhabitants with agriculture as the predominant way of living.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…No previous treatment of schistosomiasis had been administrated in the area for the last one year prior to this study. Bathing and swimming in the canals were the most frequent causes of schistosomiasis transmission [4].…”

Section: Study Design and Populationmentioning

confidence: 99%

“…The sugar cane schemes showed the higher rate of infection, 24%, 25.6%and 27% in Kenana, White Nile, and Sennar schemes respectively [2,3,4]. Studies carried out in Sennar states showed different rates of infections ranging from 5.0% to 47% in different villages of the states with overall prevalence of S. mansoni was found to be 27% [4]. Epidemiological assessment of the disease is usually based on detection of eggs in faeces using Kato-Katz technique.…”

Section: Introductionmentioning

confidence: 99%

“…The overall infections are varied according to area [ 1 ]. The sugar cane schemes showed the higher rate of infection, 24%, 25.6%and 27% in Kenana, White Nile, and Sennar schemes respectively[ 2 , 3 , 4 ]. Studies carried out in Sennar states showed different rates of infections ranging from 5.0% to 47% in different villages of the states with overall prevalence of S .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a rapid diagnostic test for Schistosoma mansoni infection based on the detection of circulating cathodic antigen in urine in Central Sudan

2020

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Background The Kato-Katz thick smear is the standard test for the diagnosis of Schistosoma mansoni infection, but the sensitivity of this technique is low. As an alternative, (CCA) strip test has been evaluated with the conclusion that it may replace the Kato-Katz method in areas where prevalences are moderate or high. Therefore, this study was undertaken to evaluate the performance of the CCA strip test in the diagnosis and monitoring of S. mansoni infection in Sudan. Methodology 489 stool and urine samples were collected from school children in endemic area of Sudan to determine the validity of CCA strip test based on duplicate Kato-Katz thick smear technique. Additional, 118 samples from known non schistosome-endemic area were collected to assess the CCA cross reactivity with other pathogens rather than schistosomiasis. The stability of CCA in urine samples was determined by consecutive examination of 40 positive CCA urine samples. 81 samples were used to evaluate the CCA strip test for the assessment of cure one week, three weeks and six weeks post Praziquantel treatment.

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Section: Study Design and Populationmentioning

confidence: 99%

Section: Study Design and Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of a rapid diagnostic test for Schistosoma mansoni infection based on the detection of circulating cathodic antigen in urine in Central Sudan

2020

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“…The Widal test, which detects agglutinating antibodies to somatic lipopolysaccharide O antigens and flagella H antigens was introduced over a century ago and remains a widely used tool for the serological diagnosis of enteric fever (el-Shafie, 1991;House et al, 2001). In Sudan, despite the high endemicity of both schistosomiasis and enteric fever (elShafie, 1991;Ahmed et al, 2012;Ibrahim and Ibrahim, 2014), there is little available data on SchistosomaSalmonella infections (Salih et al, 1977). Therefore, the present study aimed to determine the presence of typhoid and paratyphoid Salmonella among schistosomiasis patients in Managil region, Central Sudan and to detect the most common Salmonella serotypes that cause enteric fever.…”

Section: Introductionmentioning

confidence: 99%

Frequent carriage of invasive Salmonellae amongst patients infected with schistosomiasis in Sudan

Salem¹,

Bilal²,

Ibrahim³

2015

Afr. J. Microbiol. Res.

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Bacteria-parasite association has been documented as a factor that is responsible for continued and prolonged bacterial infection, such as typhoid and paratyphoid fever in schistosomiasis patients. This work aimed to determine the presence of typhoid and paratyphoid Salmonella among schistosomiasis patients and to evaluate the efficacy of Widal test on such population. A cross sectional descriptive study was conducted between November 2005 and May 2006 in Managil region, Gezira State, Sudan. A total of 203 males participated in the study. Urine, stool and blood samples were collected and processed for the investigation of schistosomiasis and Salmonella infection based on standard methods. Widal test was performed to estimate diagnostic cut-off value of enteric fever. Of the 203 studied subjects, 42 (20.7%) were diagnosed with Schistosoma haematobium, whereas eight (3.9%) had Schistosoma mansoni infection. Of these, Salmonella species were detected in 30 (60%) cases, of which Salmonella typhi represented 63.3%, followed by Salmonella paratyphi A and B (16.7%, each) and Salmonella paratyphi C (3.3%). Based on the culture results (n=30) as a diagnostic method used for enteric fever, Widal test was positive in 12 cases, with a sensitivity of 40% and specificity of 75%. Of the Widal positive cases, titers of 1:160, 1:320, 1:640 were detected in 58.3, 33.3 and 8.3% of samples, respectively. In schistosomiasis endemic regions, enteric fever was associated with schistosomiasis, which requires investigation of both infections concomitantly. Regardless of the low sensitivity of Widal test, titer of ≥1/160 is a diagnostic value for enteric fever in this study group.

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A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis

Abdalkareem¹,

Yin²

2019

TOIDJ

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Background: Schistosomiasis is one of the parasitic infections that are often found in humans. More than approximately 200 million people are infected with Schistosomiasis in tropical and subtropical areas of Africa, South America and Asian countries. Literature has long been suggesting the correlation between Schistosomiasis and colorectal malignancy. There is a considerable directory supporting the etiological relation between Schistosoma japonicum infection and colorectal cancer in the Far East, however, the available data about the role of Schistosoma mansoni that can initiate the carcinogenesis of colorectal remain insignificant. Objective: As such, more studies of this disease should be conducted comprehensively for corporate social responsibility internationally. Methods: The present study reviewed the available data about the role of Schistosoma, including S. mansoni in association with the carcinogenesis of colorectal. Results: The study shows the possible evidence of epidemiology, pathology, molecules and immunopathology associated with Schistosomal infections and colorectal cancer. The infections are apparently getting little attention nor support worldwide due to the geographical barriers and some political issues because it mainly occurs in the people living in the bottom billion and happens in the endemic regions only. Conclusion: The in-depth study of this infectious disease will tailor early diagnosis, novel prescription drugs and cost-effective strategies for the treatment of infectious disease colorectal cancer, and hence eradicate the disease in the endemic regions.

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Evaluation of microscopical and serological techniques in the diagnosis of Schistosoma mansoni infection at Sennar State, Central Sudan

Cited by 3 publications

References 28 publications

Evaluation of a rapid diagnostic test for Schistosoma mansoni infection based on the detection of circulating cathodic antigen in urine in Central Sudan

Evaluation of a rapid diagnostic test for Schistosoma mansoni infection based on the detection of circulating cathodic antigen in urine in Central Sudan

Frequent carriage of invasive Salmonellae amongst patients infected with schistosomiasis in Sudan

A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis

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