Schistosomiasis in Gynaecology

Charlewood, G. P.; Shippel, S.; Renton, Harold

doi:10.1111/j.1471-0528.1949.tb07107.x

Cited by 62 publications

(36 citation statements)

References 5 publications

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“…19,21,22,27,[30][31][32][33][34][35] These studies did not include control populations. However, the findings are in line with results from experimental studies on hepato-intestinal schistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

HIV Target Cells in Schistosoma haematobium-Infected Female Genital Mucosa

Jourdan

Holmen²,

Gundersen³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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The parasite Schistosoma haematobium frequently causes genital lesions in women and could increase the risk of human immunodeficiency virus (HIV) transmission. This study quantifies the HIV target cells in schistosome-infected female genital mucosa. Cervicovaginal biopsies with and without schistosomiasis were immunostained for quantification of CD4+ T lymphocytes (CD3, CD8), macrophages (CD68), and dendritic Langerhans cells (S100 protein). We found significantly higher densities of genital mucosal CD4+ T lymphocytes and macrophages surrounding schistosome ova compared with cervicovaginal mucosa without ova (P = 0.034 and P = 0.018, respectively). We found no increased density of Langerhans cells (P = 0.25). This study indicates that S. haematobium may significantly increase the density of HIV target cells (CD4+ T lymphocytes and macrophages) in the female genitals, creating a beneficial setting for HIV transmission. Further studies are needed to confirm these findings and to evaluate the effect of anti-schistosomal treatment on female genital schistosomiasis.

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Section: Discussionmentioning

confidence: 99%

HIV Target Cells in Schistosoma haematobium-Infected Female Genital Mucosa

Jourdan

Holmen²,

Gundersen³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…Ovarian carcinoma Ocular lymphoma High [7,[23][24][25][26][27][28][29] Low [30] Low [33] Mycobacterium tuberculosis Lung carcinoma Kaposi"s sarcoma Low [38][39][40][41][42][43] Low [44,45] Schistosoma species [54][55][59][60][61][62][63][64][65][66][67]73] Low [56,[74][75][76][77][78] Low [70] Low [80] Low [81][82] Tropheryma whippelii Lymphoma Gastric adenocarcinoma Low [108] Low [110] Liver flukes 1.Opisthorchis viverrini 2. Clonorchis sinensis…”

Section: Lung Carcinomamentioning

confidence: 99%

“…haematobium-associated bladder cancer is histopathologically distinct from non-S. haematobium associated bladder cancer that occurs in North America and Europe. The former cancer is usually a high-grade squamous cell carcinoma that mainly affects individuals of middle age, sparing the bladder"s trigone [14,49,58,69,[71][72][73][74]. There is a noteworthy relationship between the long duration of the inflammatory process due to S. haematobium and the increased possibility for development of malignant disease [68].…”

Section: Schistosoma Species and Cancer Developmentmentioning

confidence: 99%

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Chronic bacterial and parasitic infections and cancer: a review

Samaras

Rafailidis

Mourtzoukou

et al. 2010

J Infect Dev Ctries

111

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Background: A relatively underestimated facet of infectious diseases is the association of chronic bacterial and parasitic infections with cancer development. Therefore, we sought to evaluate the evidence regarding the association of such infections with the development of malignancy, excluding the overwhelming evidence of the association of Helicobacter pylori and cancer. Methodology: We searched Pubmed, Cochrane, and Scopus without time limits for relevant articles. Results: There is evidence that some bacterial and parasitic infections are associated with cancer development. The level of evidence of this association varies from high to low; in any case, a long time interval is mandatory for the development of cancer. A high level of evidence exists for the association of Salmonella Typhi with gallbladder and hepatobiliary carcinoma; Opisthorchis viverrini and Clonorchis sinensis with cholangiocarcinoma; Schistosoma hematobium with bladder cancer; chronic osteomyelitis with squamous cell carcinoma of the skin; and hidradenitis suppurativa with squamous cell carcinoma of the skin. In contrast, the level of evidence regarding the association of Chlamydia spp. with cancer is low. Mycobacterium tuberculosis is associated with lung cancer, albeit probably not etiopathogenetically. Conclusions: A considerable number of bacterial infections and parasitic infections are associated with the development of cancer. Further research into recognizing additional associations of bacterial and parasitic infections with cancer is mandatory.

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“…For these same cases Crichton and Birch (1964) do not believe such lesions are premalignant. Charlewood, Shippel, and Renton (1949), from their Johannesburg experience, considered bilharzia as a primary cause of infertility in South Africa.…”

Section: Intestinal Schistosomiasismentioning

confidence: 98%

The surgical importance of bilharziasis in south africa

Chapman

1966

British Journal of Surgery

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Schistosomiasis in Gynaecology

Cited by 62 publications

References 5 publications

HIV Target Cells in Schistosoma haematobium-Infected Female Genital Mucosa

HIV Target Cells in Schistosoma haematobium-Infected Female Genital Mucosa

Chronic bacterial and parasitic infections and cancer: a review

The surgical importance of bilharziasis in south africa

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