Schistosoma mansoni: control of female fertility by the male

Kunz, Werner; Gohr, Lutz G.; Grevelding, Christoph G.; Schüssler, P; Sommer, Gabriele; Menrath, M.; Michel, Anja

doi:10.1590/s0074-02761995000200010

Cited by 14 publications

(6 citation statements)

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“…Although Sch B causes slight damage to the male adult worm (Fig 8D -8F Differences in the damage to different sex could be explained by their mating position. During mating, female worms reside in the gynecophoral canal of male worms for sexual maturation and egg production [77,78], making the female less likely to be exposed to Sch B. Male worms are therefore exposed and become irreparably damaged.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo

2021

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Schistosomiasis is second only to malaria as the most devastating parasitic disease in the world. It is caused by the helminths Schistosoma mansoni (S. mansoni), S. haematobium, or S. japonicum. Typically, patients with schistosomiasis suffer from symptoms of liver fibrosis and hepatosplenomegaly. Currently, patients were treated with praziquantel. Although praziquantel effectively kills the worm, it cannot prevent re-infection or resolve liver fibrosis. Also, current treatment options are not ample to completely cure liver fibrosis and splenic damages. Moreover, resistance of praziquantel has been reported in vivo and in vitro studies. Therefore, finding new effective treatment agents is urgently needed. Schisandrin B (Sch B) of Schisandra chinensis has been shown to protect against different liver injuries including fatty liver disease, hepatotoxicity, fibrosis, and hepatoma. We herein investigate the potential of using Sch B to treat S. mansoni-induced liver fibrosis. Results from the present study demonstrate that Sch B is beneficial in treating S. mansoni-induced liver fibrosis and splenic damages, through inhibition of inflammasome activation and apoptosis; and aside from that regulates host immune responses. Besides, Sch B treatment damages male adult worm in the mice, consequently helps to reduce egg production and lessen the parasite burden.

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Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo

2021

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“…Paired females have also been reported to have more systemic mitotic activity than virgin females as shown by incorporation of tritiated thymidine, with the most densely labeled cells being stage-1 vitellocytes [20]. Moreover, transcription of a number of genes, including p14, within vitellocytes has been reported to be dependent on pairing [21], [22]. Upon separation from males, there is a reported decrease in uptake of tritiated thymidine by the female, and cessation of expression of genes that are specifically expressed in vitelline cells, that are reversed upon repairing [20] [22].…”

Section: Introductionmentioning

confidence: 99%

Cell Death and Reproductive Regression in Female Schistosoma mansoni

2012

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The vitellarium is a highly proliferative organ, producing cells which are incorporated along with a fertilized ovum into the schistosome egg. Vitellarial growth fails to occur in virgin female schistosomes in single sex (female-only) infections, and involution of this tissue, which is accompanied by physical shrinkage of the entire worm, occurs when mature females sexually regress upon removal from their male partners. We have found that upon removal from their hosts into tissue culture, female parasites regress whether they are mated or not, but that cessation of egg production and a decline in expression of the vitelline gene p14 is delayed by mating. We used BrdU labeling to investigate whether there was a loss of proliferation in the vittelarium that might account for regression and found that the proliferation rate declined equally in paired and singled females once placed into culture. However, TUNEL staining and Caspase 3 activity measurements indicate that the loss of vitrellarial cellularity associated with regression is associated with profound apoptotic vitelline cell death, which is not apparent in the vitellaria of paired females immediately ex vivo, and which develops in vitro regardless of whether males are present or not. Furthermore, primordial vitellaria in virgin females have a high frequency of apoptotic cells but are characterized by a proliferation rate that is indistinguishable from that in fully developed vitellaria in mature paired females. Taken together, our data suggest that the vitelline proliferation rate is independent of pairing status. In contrast, the survival of vitelline cells, and therefore the development of the vitellarium, is highly male-dependent. Both processes are negatively affected by removal from the host regardless of whether male worms are present or not, and are unsustainable using standard tissue culture approaches.

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“…This phenomenon suggests that more influence or effects from the host on the female worms mainly focus on the structural composition, while more effects from the host on the male worms mainly focus on the molecular function. This could be addressed as the growth and development of the female worms being dependent on interactions with the male worms as well as their hosts (Shaw et al, 1977;Den Hollander and Erasmus, 1985;Gupta and Basch, 1987;Haseeb et al, 1989;Siegel and Tracy, 1989;Haseeb and Eveland, 1991;Kunz et al, 1995;Kunz, 2001;Hernandez et al, 2004;Han et al, 2009;deWalick et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analyses of Schistosoma japonicum Derived From SCID Mice and BALB/c Mice: Clues to the Abnormality in Parasite Growth and Development

Liu¹,

Cheng²,

Ye³

et al. 2020

Front. Microbiol.

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Frontiers in Microbiology | www.frontiersin.org March 2020 | Volume 11 | Article 274 Liu et al.Transcriptome Analysis of S. japonicum From Mice expression profiles of schistosomes from SCID mice when compared with those from BALB/c mice, which were potentially involved in regulating the growth and development of schistosomes. These findings contributed to an understanding of parasite biology and provided a rich resource for the exploitation of antischistosomal intervention targets.

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Schistosoma mansoni: control of female fertility by the male

Cited by 14 publications

References 0 publications

Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo

Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo

Cell Death and Reproductive Regression in Female Schistosoma mansoni

Comparative Transcriptome Analyses of Schistosoma japonicum Derived From SCID Mice and BALB/c Mice: Clues to the Abnormality in Parasite Growth and Development

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