Schinus terebinthifolia leaf lectin (SteLL) is an immunomodulatory agent by altering cytokine release by mice splenocytes

Santos, Ardilles Juan Carlos Alves dos; Barros, Bárbara Rafaela da Silva; Aguiar, Lethícia Maria de Souza; Patriota, Leydianne Leite de Siqueira; Lima, Thâmarah de Albuquerque; Zingali, Russolina B.; Paiva, Patrícia Maria Guedes; Napoleão, Thiago Henrique; Melo, Cristiane Moutinho Lagos de; Pontual, Emmanuel Viana

doi:10.1007/s13205-020-2137-2

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…Plant lectins can induce the expression of humoral effectors against tumors or microbial infections [136,[141][142][143]. Activated macrophages can produce cytokine signal molecules.…”

Section: Plant Lectins Promote the Release Of Cytokines And Other Effectorsmentioning

confidence: 99%

“…The lectins stimulate cytokine production in different types of immune-related mammalian cells, such as murine macrophages, spleen cells, dendritic cells, mouse spleen cells, and human dendritic cells, neutrophils, peripheral blood mononuclear cells, etc. [136,142,143].…”

Section: Plant Lectins Promote the Release Of Cytokines And Other Effectorsmentioning

confidence: 99%

“…While the plant-lectin-induced insect immune responses are far from being clear, plant lectins can still be useful tools to investigate insect innate immunity. First of all, in mammalian systems, plant lectins have been analyzed in more detail for their immunomodulatory effects, especially regarding receptors on the cell membrane and in the cytosol, in both the cellular and humoral immune responses [136,[141][142][143]. In addition, the signaling pathways behind these responses have been extensively studied in vertebrate models [131].…”

Section: Plant Lectins As a Tool To Study Insect Immune Responsesmentioning

confidence: 99%

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Can Plant Lectins Help to Elucidate Insect Lectin-Mediated Immune Response?

Chen

Schutter

Damme

et al. 2021

Insects

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Lectins are carbohydrate-binding proteins that recognize and selectively bind to specific sugar structures. This group of proteins is widespread in plants, animals, and microorganisms, and exerts a broad range of functions. Many plant lectins were identified as exogenous stimuli of vertebrate immunity. Despite being the largest and most diverse taxon on earth, the study of lectins and their functions in insects is lagging behind. In insects, research on lectins and their biological importance has mainly focused on the C-type lectin (CTL) family, limiting our global understanding of the function of insect lectins and their role in insect immunity. In contrast, plant lectins have been well characterized and the immunomodulatory effects of several plant lectins have been documented extensively in vertebrates. This information could complement the missing knowledge on endogenous insect lectins and contribute to understanding of the processes and mechanisms by which lectins participate in insect immunity. This review summarizes existing studies of immune responses stimulated by endogenous or exogenous lectins. Understanding how lectins modulate insect immune responses can provide insight which, in turn, can help to elaborate novel ideas applicable for the protection of beneficial insects and the development of novel pest control strategies.

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“…Plant lectins can induce the expression of humoral effectors against tumors or microbial infections [136,[141][142][143]. Activated macrophages can produce cytokine signal molecules.…”

Section: Plant Lectins Promote the Release Of Cytokines And Other Effectorsmentioning

confidence: 99%

Section: Plant Lectins Promote the Release Of Cytokines And Other Effectorsmentioning

confidence: 99%