Schiff’s Bases Metal complexes in Biological Applications

Kulkarni, Ajaykumar D.

doi:10.15406/japlr.2017.05.00127

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…The synthesis of various metal complexes from the Schiff's base ligand which is the part of coordination chemistry and gaining prominence nowadays. Further, these metal complexes are used for various biological applications like antimicrobial agents and other applications such as Deoxyribonucleic Acid (DNA) cleaving agents, as sensors etc [17].…”

Section: Fig 9: Metal Complexes Of Anthranilic Acid Derivatives Subst...mentioning

confidence: 99%

Development of Organometallic Compounds of Schiff Bases With Diverse Applications

Dinnimath

Gowda

Naik

2023

Int J Pharm Pharm Sci

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Schiff bases are well-known synthetic compounds which are known to be used as drug molecules for various pharmacological and therapeutic applications. These compounds were prepared synthetically in simple steps and used against various diseases as antimicrobial agents, anti-HIV agents, antitumour agents, industrial applications like enzymatic reactions, catalytic activity. However, considering the various challenges posed by different microorganisms to the conventional Schiff bases, medicinal chemists have initiated the novel approach by synthesizing the new lead compounds for different pharmacological activities containing complexes of Schiff bases with different metals as these are new compounds and potent molecules due to duo combination with metals. This combination has gained prominence now a days against those diseases for which Schiff bases are becoming ineffective, such as cancer due to resistance and irrational usage. Hence, this review is an attempt to throw some light on the recent developments in the world of new drug molecules comprising of Schiff bases complexes with different metals like Copper (Cu), Palladium (Pd), Aluminium (Al), gold (Au), Silver (Ag) etc.

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Section: Fig 9: Metal Complexes Of Anthranilic Acid Derivatives Subst...mentioning

confidence: 99%

Development of Organometallic Compounds of Schiff Bases With Diverse Applications

Dinnimath

Gowda

Naik

2023

Int J Pharm Pharm Sci

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“…Moreover, Schiff bases are also found to be excellent pharmcophore, and therefore nd promising applications in modern drug discovery [29,30]. A variety of schiff base compounds has been reported to exhibit a broad spectrum of biological activities, including anti-tumour, anti-bacterial, antifungicidal and anticarcinogenic properties [31,32]which also tempted us to explore the role of our synthesized compound as an anticancer drug by attempting in-silico docking studies on target protein.…”

Section: Introductionmentioning

confidence: 99%

Thiadiazole Functionalized Salicylaldehyde-Schiff Base as a pH-responsive and chemo-reversible “Turn-Off” fluorescent probe for selective cu (II) detection: Logic Gate Behaviour and Molecular Docking Studies

et al. 2022

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A novel thiadiazole functionalized schiff base chemoreceptor (E)-2,4-dichloro-6-(((5-mercapto-1,3,4thiadiazol-2-yl)imino)methyl)phenol (SB-1) has been synthesized and characterized spectroscopically by using various techniques. Its photophysical behaviour was scanned towards a variety of metal ions in mixed aqueous media. The chemosensor (SB-1) displayed excellent selectivity towards Cu 2+ ion through uorescent diminishment (turn-off phenomenon). Colorimetric analyses showed a rapid colour change from yellow to dark red under visible light upon addition of Cu 2+ ions. Interestingly, the original yellow colour reappeared back instantly after the addition of EDTA 2anions, thus con rming the reversible nature of SB-1. Competitive experiments validated no interference from the other co-existing metal ions in the recognition process of SB-1 towards Cu 2+ ion. Job's plot con rmed 1:1 binding stoichiometry between SB-1 and Cu 2+ ion with the binding constant value of 3.87×10 4 M -1 . The limit of detection was determined to be 1.01×10 -7 M suggesting good sensitivity of SB-1 towards Cu 2+ ions. Furthermore, pH-dependent UV-Vis spectral behaviour of SB-1 con rmed that it could act as an effective optical pH-sensor for highly acidic environment as well. Portable nature of probe SB-1 was explored by fabricating "easy-to-use" paper test strips, which allow robust and rapid detection of Cu 2+ ions. Based on the multi-responsive properties of SB-1, a 'NOR' logic gate was constructed by applying Cu 2+ and EDTA 2as chemical inputs (ln1: Cu 2+ , ln2: EDTA 2-) while emission intensity observed at 560 nm was considered as output signal (O1). DFT optimized geometries con rmed that chemosensor SB-1 exists in Azo form (Enol form) in its ground state. Molecular docking of the SB-1 and its copper complex, into the binding site of TRK protein tyrosine kinase (PDB: 1t46) was also carried out to explore their biological activity and their potential use as TRK inhibitors.

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“…A lot of work has been reported on how structure influences the properties of molecules [1,2]. Organic Schiff bases have been investigated and reported for their medicinal applications [3,4]. Some of them have been applied as nonlinear optical (NLO) materials and served as a protective shield for the human eyes and other sensors from intense laser lights/beams [5,6] while some have been used to inhibit the corrosion of metals [7,8].…”

Section: Introductionmentioning

confidence: 99%

Investigation into the Molecular Properties of 3-(4-Hydroxyphenyl) Prop-2-en-1-one 4-Phenyl Schiff Base and Some of Its Derivatives-DFT and Molecular Docking Studies

2021

Sci. Lett.

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The structure-property relationship is important in understanding molecular behaviors and their best-fit areas of applications. 3-(4-hydroxyphenyl) prop-2-en-1-one 4-phenyl Schiff base and some of its derivatives were optimized via the density functional theory with Becke three Lee Yang Parr correlation and 6-31G* basis set. The molecular properties calculated were the energies of the frontier molecular orbitals [highest occupied molecular orbital (EHOMO), lowest unoccupied molecular orbital (ELUMO), energy bandgap (Eg), chemical hardness (η), softness (S) and hyperpolarizabilities (β)]. The electronic transitions were calculated with the time-dependent density functional theory methods, the absorption maxima (λabs), vertical transition energies (ΔEge), oscillator strengths (f) and molecular orbital (MO) components with their percentage contributions were obtained. The anti-microbial efficacy of the molecules was tested against Staphylococcus aureus aminopeptidase S (AmpS) active site to predict the binding affinities. ADMEtox parameters of all the molecules were also investigated. Eg values ranged from 3.13 to 3.95 eV, β values ranged from 1.45 to 5.81×10-30 esu, and their binding affinities ranged from -4.57 to -6.12 kcal/mol, all were more than that of standard drug, streptomycin (-4.31 kcal/mol). The number of hydrogen bond donors and hydrogen bond acceptors were ranged from 1 to 2 and 3.75 to 5.25, respectively. Variations observed from the calculated molecular properties are the result of varying substituent groups. The molecules can be used as nonlinear optical (NLO) materials and also showed potential for being effective against Staphylococcus aureus.

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Schiff’s Bases Metal complexes in Biological Applications

Cited by 7 publications

References 34 publications

Development of Organometallic Compounds of Schiff Bases With Diverse Applications

Development of Organometallic Compounds of Schiff Bases With Diverse Applications

Thiadiazole Functionalized Salicylaldehyde-Schiff Base as a pH-responsive and chemo-reversible “Turn-Off” fluorescent probe for selective cu (II) detection: Logic Gate Behaviour and Molecular Docking Studies

Investigation into the Molecular Properties of 3-(4-Hydroxyphenyl) Prop-2-en-1-one 4-Phenyl Schiff Base and Some of Its Derivatives-DFT and Molecular Docking Studies

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