Schiff Bases as Potential Fungicides and Nitrification Inhibitors

Abstract

A number of substituted Schiff bases were synthesized and characterized by (1)H NMR and mass spectrometry. These compounds were screened for antifungal activity in vitro against pathogenic fungi, namely, Sclerotium rolfsii and Rhizoctonia bataticola, and for their effect on nitrification inhibition under laboratory conditions. Maximum antifungal activity was exhibited by (2,4-dichlorobenzylidene)-(2,4,5-trichlorophenyl)-amine and (3-nitrobenzylidene)-(2,4,5-trichlorophenyl)-amine against both fungi (ED(50) with range from 3 to 24 microg/mL). Maximum nitrification inhibition (NI) was exhibited by (2,4-dichlorobenzylidene)-(2-fluorophenyl)-amine, (4-fluorophenyl)-(3-nitrobenzylidene)-amine, (2,6-dichlorobenzylidene)-(4-fluorophenyl)-amine, and (2,6-dichlorobenzylidene)-(3 fluorophenyl)-amine (NI in the range 91-96%).

Synthesis, biological activities and SAR studies of novel 1‐Ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro‐[1,8]naphthyridine‐3‐carboxylic acid based diacyl and sulfonyl acyl hydrazines

“…The earlier synthesized compounds were also evaluated for their effect on nitrification inhibition at a 5% dose according to the following reported method …”

Metal complexes of tetradentate azo‐dye ligand derived from 4,4′‐oxydianiline: Preparation, structural investigation, biological evaluation and MOE studies

“…[4] Azo-dyes have biological activities such as antibacterial, antifungal, anti-HIV and antitumor, so they have immense importance in medicinal chemistry. [5,6] On the other hand, they are widely used as structural controllers of biomaterials, optical recording devices, photovoltaic devices, molecular switches, photoelectronics and in printing systems. [7] Furthermore, they have important roles in food and analytical chemistry.…”

A family of silatrane‐armed triazole‐encapped salicylaldehyde‐derived Schiff bases: Synthesis, spectral analysis, and antimicrobial and quantum chemical evaluation

“…It is beneficial to instigate this development through fragments with potential drug profiles . In this context, Schiff base derivatives have been extensively investigated due to their excellent biological properties credited to the presence of azomethine functionality . Triazolyl Schiff base derivatives are hybrids with a heterocyclic core and an azomethine linkage providing an excellent pharmacological role .…”