Schiff bases: A short review of their antimicrobial activities

Silva, Cleiton M. da; Silva, Daniel L. da; Modolo, Luzia V.; Alves, Rosemeire Brondi; Resende, Maria Aparecida de; Martins, Cleide Viviane Buzanello; Fátima, Ângelo de

doi:10.1016/j.jare.2010.05.004

Cited by 895 publications

(401 citation statements)

References 71 publications

(86 reference statements)

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“…[9][10][11][12][13] Thus, they play an important role in revealing the preferred coordination geometries of metal complexes due to their preparative accessibility, diversity and structural variability. [14][15][16] These properties of Schiff bases and their complexes have resulted in wide applications in the biological field [17] Cu (II) complexes are known to be effective against rheumatoid arthritis and they also show anti-ulcer activity. [18] This is because gastrointestinal irritation often precludes treatment by other antiarthritic drugs.…”

Section: Introductionmentioning

confidence: 99%

A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

Zoubi

Al‐Hamdani

Ahmed

et al. 2017

Applied Organom Chemis

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A new Azo-Schiff base ligand L was prepared by reaction of m-hydroxy benzoic acid with (Schiff base B) of 3-[2-(1H-indol-3-yl)-ethylimino]-1.5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamine. This synthesized ligand was used for complexation with different metal ions like Ni(II), Co(II), Pd(II) and Pt(IV) by using a molar ratio of ligand: metal as 1:1. Resulted compounds were characterized by NMR ( 1 H and 13 C), UV-vis spectroscopy, TGA, FT-IR, MS, elemental analysis, magnetic moment and molar conductivity studies. The activation thermodynamic parameters, such as ΔE*, ΔH * , ΔS * , ΔG * and K are calculated from the TGA curves using Coats-Redfern method. Hyper Chem-8 program has been used to predict structural geometries of compounds in gas phase. The biological activities of Schiff base and its complexes had been tested in vitro against, two Gram positive bacteria (Bacillus subtillis and Staphylococcus aureus) and two Gram negative bacteria (Escherichia coli and Pseudomonas aeruguinosa).

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Section: Introductionmentioning

confidence: 99%

A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

Zoubi

Al‐Hamdani

Ahmed

et al. 2017

Applied Organom Chemis

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show abstract

“…Extended interest to the Schiff bases is caused by their use as starting materials in the synthesis of important drugs, such as antibiotics and antimalarial, antifungal, and antitumor substances [1][2][3][4][5], as components of rubber compounds [6], or as ligands for the complexation of metal ions [7][8][9]. The bond lengths and angles in the title crystal structure are in normal ranges.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of (E)-4-chloro-2-(isopropyliminomethyl)phenol, C10H12ClNO

Lin¹,

Zhou²,

Wu³

et al. 2010

Zeitschrift Für Kristallographie - New Crystal Structures

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C 10 H 12 ClNO, monoclinic, C12/c1(no. 15), a =21.459(2) Å, b =5.6893(6) Å, c =17.760(2) Å, b =105.137(2)°, Source of materialAll reagents and solvents were used as purchased without further purification. 5-chloro-2-hydroxybenzaldehyde (147 mg, 1m mol), propan-2-amine (118 mg, 2m mol) were dissolved in methanol (15 mL). The mixture was refluxd for aperiod of 8h and, after cooling to room temperature, was filtered. The filtrate was kept still in air for one week. Large block-shaped crystals were precipitated. They were filtered and washed with ethanol and dried in avacuum desiccator using anhydrous CaCl 2 (yield 89 %). Experimental detailsAll Hatoms were positioned geometrically and refined as riding with d(C-H) =0.93 -0.98 Å), U iso (H) =1.2 or 1.5 U eq (C), respectively. The instability of isopropyl group and the poor quality of the crystals result in quite large residual values. DiscussionExtended interest to the Schiff bases is caused by their use as starting materials in the synthesis of important drugs, such as antibiotics and antimalarial, antifungal, and antitumor substances [1][2][3][4][5], as components of rubber compounds [6], or as ligands for the complexation of metal ions [7][8][9]. The bond lengths and angles in the title crystal structure are in normal ranges. The C7=N1 bond length of 1.263(4) Å conforms to the value of adouble bond. The torsion angle N1-C7-C1-C6 is -178.94(3)°.Inthe crystal packing, the molecules are linked by several weak intermolecular C-H···Ointeractions.

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“…The singlet peak at 8.28 ppm is for H 11 4 and H 5 protons in axial position. For a given carbon atom, proton in equatorial position is more deblinded than in axial position one 14 .…”

Section: Nmr Studymentioning

confidence: 99%

“…Table 1. Selected bond lengths and angles (Å, °) C 5 -C 6 1.510 (5) C 6 -C 5 -C 4 111.7 (4) C 5 -C 4 1.511 (6) C 5 -C 4 -C 3 109,55(4) C 4 -C 3 1.523 (5) C 4 -C 3 -C 2 112.6 (4) C 2 -C 3 1.522 (4) 7 1.259 (4) N 2 =C 7 -C 8 119.7 (3) C 7 -C 8 1.474 (4) C 8 -C 13 -C 12 119.6 (3) C 8 -C 9 1.404 (4) C 13 -C 12 -C 11 122.7 (4) C 9 -C 10 1.372 (5) C 12 -C 11 -C 10 118.4 (4) C 10 -C 11 1.370 (5) C 11 -C 10 -C 9 120.0 (4) C 11 -C 12 1.383 (5) C 9 -C 8 -C 13 117.8 (4) C 12 -C 13 1 16 1.401 (4) C 7 -N 2 -C 1 -C 2 126,0(4) C 17 -C 18 1.386 (5) C 14 -N 3 -C 2 -C 1 123,4(3) C 18 -C 19 1.384 (5) Conformational analysis of the structure obtained clearly shows that the hexanic cycle adopts chair conformation more stable than the boat form [21][22][23] .…”

Section: X-ray Analysismentioning

confidence: 99%

See 1 more Smart Citation

Preparation, Spectroscopy and X-Ray Structure Analysis of N, Nʹ-Bis(3-nitrophenylmethylene)- cyclohexane-1,2-diamine

2017

Chem Sci Trans

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The compound N,cyclohexane-1,2-diamine (α-diimine Shiff base) was synthesized and characterized by MS, IR, NMR 1 H and X-ray single crystal analysis. While the cyclohexane-1,2-diamine used for the synthesis of this composite is a racemic cis and trans mixture, we observed by x-ray diffraction for the product N,N'-bis(3-nitrophenylmethylene) cyclohexane-1,2-diamine only the (1R,2R)trans enantiopure. The crystalline network cohesion of this compound is assured by a combination of C-H ... O and C-H ... N hydrogen bonds. It crystallizes in the monoclinic non-standard I2/a space group.

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Schiff bases: A short review of their antimicrobial activities

Cited by 895 publications

References 71 publications

A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

Crystal structure of (E)-4-chloro-2-(isopropyliminomethyl)phenol, C10H12ClNO

Preparation, Spectroscopy and X-Ray Structure Analysis of N, Nʹ-Bis(3-nitrophenylmethylene)- cyclohexane-1,2-diamine

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