Crystal structure of (E)-4-chloro-2-(isopropyliminomethyl)phenol, C10H12ClNO

Abstract

C 10 H 12 ClNO, monoclinic, C12/c1(no. 15), a =21.459(2) Å, b =5.6893(6) Å, c =17.760(2) Å, b =105.137(2)°, Source of materialAll reagents and solvents were used as purchased without further purification. 5-chloro-2-hydroxybenzaldehyde (147 mg, 1m mol), propan-2-amine (118 mg, 2m mol) were dissolved in methanol (15 mL). The mixture was refluxd for aperiod of 8h and, after cooling to room temperature, was filtered. The filtrate was kept still in air for one week. Large block-shaped crystals were precipitated. They were filtered and washed with ethanol and dried in avacuum desiccator using anhydrous CaCl 2 (yield 89 %). Experimental detailsAll Hatoms were positioned geometrically and refined as riding with d(C-H) =0.93 -0.98 Å), U iso (H) =1.2 or 1.5 U eq (C), respectively. The instability of isopropyl group and the poor quality of the crystals result in quite large residual values. DiscussionExtended interest to the Schiff bases is caused by their use as starting materials in the synthesis of important drugs, such as antibiotics and antimalarial, antifungal, and antitumor substances [1][2][3][4][5], as components of rubber compounds [6], or as ligands for the complexation of metal ions [7][8][9]. The bond lengths and angles in the title crystal structure are in normal ranges. The C7=N1 bond length of 1.263(4) Å conforms to the value of adouble bond. The torsion angle N1-C7-C1-C6 is -178.94(3)°.Inthe crystal packing, the molecules are linked by several weak intermolecular C-H···Ointeractions.