Schiff base SH11 with tuberculostatic and radical scavenging activities against INH-induced oxidative hepatic damage

Abstract

ABSTRACT

A Sensitive Analytical (RP-HPLC-PDA, UV/VIS) Method for the Determination of Newly Synthesized N-Isonicotinoyl-N´-(3-Fluorobenzal)Hydrazone (SH2) in Aqueous Phase

“…Previous investigations of the scientific team proved the superoxide scavenging, radical scavenging and tuberculostatic activities of substituted isonicotynoylhydrazones [9,14]. However, no analytical methods for the determination of halogenated isonicotynoylhydrazones in aqueous medium have been reported so far, which provoked the present research.…”

MFA zeotype catalyst: a greener approach for the synthesis of INH azomethine scaffolds

“…14 INH can form Schiff bases with carbonyl compounds and their metal chelates exhibit anticancer activity. 15 The azomethine derivatives of INH, derived from its condensation with 3,4-dimethoxy benzaldehyde and 3,4,5-trimethoxy benzaldehyde, are known to show antimicrobial activity, 16 while those derived from 3-methoxy-4-hydroxy benzaldehyde and 4-oxypropane benzaldehyde are known as the most potent antioxidants with signicant hydrogen peroxide scavenging ability. 6 The present study throws light on the development of a new catalyst by the modication of y ash, the waste generated in thermal power plants.…”