MFA zeotype catalyst: a greener approach for the synthesis of INH azomethine scaffolds

Abstract

Herein, we report the green and efficient synthesis of some pharmacologically important azomethine derivatives of isoniazide (INH) using Modified Fly Ash (MFA) as an excellent zeotic solid acid catalyst.

3D Architectured polyazomethine gel synthesis: its self-assembled intercalating complexation with nitro aromatic acceptor

“…Schiff's base reactions are well-known organic reactions that are the main source of several versatile organic moieties and the reaction intermediates responsible for enormous applications in the diversified fields as pharmacy [1], agriculture [2,3], biosciences [4], physical sciences [5], chemical sciences [6], etc. By virtue of its virtual applicability, Schiff bases have attracted great attention in the past few decades [7] and they are very prominent in the research related to organic compounds. The application of Schiff bases in polymer sciences is less as compared to other research areas [8].…”

“…By virtue of its virtual applicability, Schiff bases have attracted great attention in the past few decades [7] and they are very prominent in the research related to organic compounds. The application of Schiff bases in polymer sciences is less as compared to other research areas [8].…”

Glycerol based carbon sulfonic acid catalyzed synthesis, in silico studies and in vitro biological evaluation of isonicotinohydrazide derivatives as potent antimicrobial and anti-tubercular agents

“…Inspite of less reaction time in some previously reported methods [ 24 , [36] , [37] , [38] ], the present protocol is more fruitful because earlier reported protocols include harsh reaction conditions, metal-contamination, tiresome process, need work-up for purification, no recyclability of catalyst, less substrate scope, etc. Whereas, the designed pathway has several benefits like reusability of catalyst up to five runs, cost-effective, excellent yields, large substrate scope.…”

“… (4 derivatives) 79–89 – [ 11 ] 5. Modified Fly Ash zeotype catalyst (10% w/w of catalyst) EtOH, RT, 5–15 min (8 derivatives) 84–93 Up to three runs [ 36 ] 6. Ceric ammonium nitrate (0.25 mmol) of catalyst, reflux, EtOH, 30 min (7 derivatives) 77–89 – [ 37 ] 7.…”

WITHDRAWN: Isonicotinoylhydrazonobutanoic acidderivatives as anti-tubercular agents: In-silico studies, synthesis, spectral characterization and biological evaluation.

“…Isoniazid (INH) and its derivatives possess various biological activities such as anticancer [5], antimicrobial [6], antibacterial [7], etc. Isoniazid is still considered as the rst-line drug against M. tb strains due to higher e ciency, lesser toxicity, and better aqua-based solubility [8] [9] [10].…”