Schiff base metallodrugs in antimicrobial and anticancer chemotherapy applications: a comprehensive review

Shekhar, Shashank; Khan, Amarendra Mohan; Sharma, Shreya; Bk, Sharma; Sarkar, Anjana

doi:10.1007/s42247-021-00234-1

Cited by 32 publications

(10 citation statements)

References 102 publications

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“…[ 43 ] The development of Schiff base compound produces eventual fate of metallodrugs either as antimicrobial or antibacterial specialists. [ 44 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural elucidation, biological screening, and density functional theory calculations of Cu(II), Ni(II), Mn(II), and Co(II) complexes of 20 Z‐N‐((Z)‐2‐(6‐nitrobenzo[d]thiazol‐2‐ylimino)‐1,2‐diphenylethylidene)‐5‐nitrobenzo[d]thiazol‐2‐amine Schiff base ligand

Shekhar

Sharma

Okolie

et al. 2022

Applied Organom Chemis

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The emerging Schiff base‐derived metal complexes are the building blocks for biomedical applications. Herein, novel Schiff base N,N′‐[(1Z,2Z)‐1,2‐diphenylethane‐1,2‐diylidene]bis(6‐nitro‐1,3‐thiazol‐2‐amine) and corresponding Cu(II), Ni(II), Mn(II), and Co(II) metal complexes were successfully synthesized and characterized. The characterization of ligand and corresponding metal complexes was carried out by employing elemental analysis, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, mass spectroscopy, Fourier transform infrared spectroscopy (FTIR) analysis, molar conductance, magnetic susceptibility measurements, electronic spectra, electronic paramagnetic resonance (EPR) and density functional theory (DFT) studies. DFT calculations at B3LYP/6‐311+G** level of theory have been executed to examine the equilibrium geometry of the ligand and metal complexes. Furthermore, total energy, highest‐occupied molecular orbital (HOMO) and lowest‐unoccupied molecular orbital (LUMO), and Mulliken atomic charges were reckoned. Tetrahedral geometry was observed in the case of the Ni(II) complex, and octahedral geometries were discerned for Cu(II), Mn(II), and Co(II), complexes. Docking studies were performed against the newly synthesized analogs with the active site of Escherichia coli (PDB ID: 3t88), Staphylococcus aureus (PDB ID: 3q8u), Candida Albicans (PDB ID: 3qlw), and Aspergillus flavus (PDB ID: 4ynt) receptors to recognize the interactions between complexes and identify their probable binding sites. Synthesized analogs were examined for in vitro antimicrobial activity employing both minimum inhibitory concentration and disk diffusion method against the aforementioned pathogens. The result for these pathogens suggested metal compounds evince higher activity in comparison to the free ligand.

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“…[ 43 ] The development of Schiff base compound produces eventual fate of metallodrugs either as antimicrobial or antibacterial specialists. [ 44 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural elucidation, biological screening, and density functional theory calculations of Cu(II), Ni(II), Mn(II), and Co(II) complexes of 20 Z‐N‐((Z)‐2‐(6‐nitrobenzo[d]thiazol‐2‐ylimino)‐1,2‐diphenylethylidene)‐5‐nitrobenzo[d]thiazol‐2‐amine Schiff base ligand

Shekhar

Sharma

Okolie

et al. 2022

Applied Organom Chemis

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“…63,64 In the past, significant research work has been done in developing fluorescent Schiff base sensors for metal ion detection. 63,[65][66][67][68][69][70][71] However, to the best of our knowledge, no review has been reported on metal ion detection using fluorescent Schiff base sensors. In this review article, we start with the general introduction of fluorescent Schiff base sensors for metal ion detection and then divide the article into main sections.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Schiff base sensors as a versatile tool for metal ion detection: strategies, mechanistic insights, and applications

Goshisht¹,

2022

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“…The improvement in electron delocalization across the chelating ring increases the lipophilicity of the complexes. As a result, the metal complexes enter the bacterial cell membranes and exert antibacterial effects through enzyme inhibition, intracellular biomolecular interactions, induction of cell cycle arrest, etc …”

Section: Introductionmentioning

confidence: 99%

Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected α-Amino Acids and Their Antibacterial Activity

Zhu

Wang

et al. 2022

J. Org. Chem.

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An operationally simple and convenient resolution method via Cu(II) complexes was reported, efficiently providing valuable enantiopure N,C-unprotected α-amino acids. This protocol features synthetically attractive yields and a stereochemical outcome, using a recyclable Schiff base ligand and inexpensive easily accessible metal copper salts. These novel Cu(II) complexes can be obtained in an enantiopure state by means of column chromatography or recrystallization. Furthermore, all the Cu(II) complexes were evaluated for their antibacterial activities. Among them, complexes (S,2S)-3a, (S,2S)-3g, and (S,2S)-3o showed significant antibacterial activities against Staphylococcus aureus Mu50. Further biological evaluation indicated that they were effective against most of Gram-positive bacteria. It is the first study on the biological activities of transition metal complexes with this type of proline-derived Schiff base ligand.

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Schiff base metallodrugs in antimicrobial and anticancer chemotherapy applications: a comprehensive review

Cited by 32 publications

References 102 publications

Synthesis, structural elucidation, biological screening, and density functional theory calculations of Cu(II), Ni(II), Mn(II), and Co(II) complexes of 20 Z‐N‐((Z)‐2‐(6‐nitrobenzo[d]thiazol‐2‐ylimino)‐1,2‐diphenylethylidene)‐5‐nitrobenzo[d]thiazol‐2‐amine Schiff base ligand

Synthesis, structural elucidation, biological screening, and density functional theory calculations of Cu(II), Ni(II), Mn(II), and Co(II) complexes of 20 Z‐N‐((Z)‐2‐(6‐nitrobenzo[d]thiazol‐2‐ylimino)‐1,2‐diphenylethylidene)‐5‐nitrobenzo[d]thiazol‐2‐amine Schiff base ligand

Fluorescent Schiff base sensors as a versatile tool for metal ion detection: strategies, mechanistic insights, and applications

Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected α-Amino Acids and Their Antibacterial Activity

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