Schedule-induced polydipsia in the Spontaneously Hypertensive Rat and its relation to impulsive behaviour

Poor inhibitory control and neurochemical differences in high compulsive drinker rats selected by schedule-induced polydipsia

“…Previous studies have shown increased impulsive choice on a delay discounting task associated with SIP drinking (Cardona et al 2006(Cardona et al , 2011Ibias and Pellón 2011). The current study did demonstrate that HD animals exhibit Data are mean ± SEM PFC prefrontal cortex, NAc nucleus accumbens, Amyg amygdala a Statistical analyses indicate significant differences between HD and LD impaired inhibitory control on the 5-CSRT task under extinction and after D-amphetamine challenge (as shown by the increase in perseverative and premature responses, respectively) and is the first study to show a relationship of HD in SIP with measures of 5-CSRTT performance.…”

Impulsivity or Sub-optimal Reward Maximization in Delay Discounting? A Critical Discussion

“…Strangely, some SHR studies do not make any mention of a preference test prior to the experiment (Hand, Fox, & Reilly, 2009;Orduña, 2015;Sutherland et al, 2009;Wooters & Bardo, 2011). Others used a test, but the details (particularly regarding the criterion) are unclear (Adriani, Caprioli, Granstrem, Carli, & Laviola, 2003;Botanas et al, 2016;Fox et al, 2008;Ibias & Pellón, 2011). Sometimes a preference test was used, but included a delay component, a variable that ideally should not be introduced until the experimental phase begins (Bizot et al, 2007;Garcia & Kirkpatrick, 2013;Pardey, Homewood, Taylor, & Cornish, 2009).…”

“…Sometimes a preference test was used, but included a delay component, a variable that ideally should not be introduced until the experimental phase begins (Bizot et al, 2007;Garcia & Kirkpatrick, 2013;Pardey, Homewood, Taylor, & Cornish, 2009). Other studies explicitly reported the details of a preference test and used no delays (Adriani et al, 2004;Íbias & Pellón, 2014;Sundbø, 2013). The issue with these findings is that comparison of data across SHR studies is difficult, because the various researchers have made different assumptions regarding the rats' preference for the large reward.…”

Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases

“…Animals that exhibited a high locomotor response to novelty (high responders) and rapidly acquired D-amphetamine self-administration also developed SIP faster than low responsive rats Piazza et al 1993). In a recent study, spontaneously hypertensive rats, characterized as hyperactive and impulsive in terms of exacerbated sensitivity to delay of reinforcement, displayed increased drinking in SIP compared with WistarKyoto rats (Ibias and Pellón 2011). Different lines of inbreeding Fischer 344 (F344) and Lewis (LEW) rats also exhibited different levels of SIP (DeCarolis et al 2003;Stöhr et al 2000).…”