Poor inhibitory control and neurochemical differences in high compulsive drinker rats selected by schedule-induced polydipsia

Moreno, Margarita; Gutiérrez-Ferre, Valeria E.; Ruedas, Luis; Campa, Leticia; Suñol, Cristina; Flores, Pilar

doi:10.1007/s00213-011-2575-y

Cited by 30 publications

(47 citation statements)

References 63 publications

(79 reference statements)

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“…Similarly, HD compulsive rats on SIP have also shown reduced serotonin 5-HT 2A receptor binding and alterations in 5-HT tone in comparison to LD rats. 39 …”

Section: Discussionmentioning

confidence: 99%

“…20,35,36 Previous studies that were performed in our laboratory have shown relevant differences between high drinker (HD) and low drinker (LD) rats that were selected according to SIP acquisition. For example, the behavioral response to a challenge with dopaminergic drugs, such as D-amphetamine and cocaine, 37 diverges in the availability of dopamine D 1 and D 2 receptors in mesolimbic brain areas 38 ; lack of inhibitory control in the 5-choice serial reaction time task (5-CSRTT); increased serotonin and noradrenalin activity in the amygdala in post-mortem brain analyses 39 ; and a reduction of compulsive drinking by the 5-HT 2A/C serotonin agonist DOI in HD rats. 40 HD rats selected by SIP have shown behavioral and neurochemical alterations that are characteristic of inhibitory control deficits; however, the knowledge of the possible co-occurrence with other behavioral biomarkers of schizophrenia remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders

Navarro

Álvarez

Colomina

et al. 2016

Schizophrenia Bulletin

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Psychogenic polydipsia, which is compulsive, non-regulatory fluid consumption, is present in 6%–20% of chronic psychiatric patients and frequently associated with the schizophrenia diagnosis. In the present study, we investigated the relation between schizophrenia-like symptoms and biomarkers with a compulsive drinking behavior phenotype in rats. Rats that were selected for low drinking vs high drinking behavior following schedule-induced polydipsia (SIP) were assessed in a latent inhibition (LI) paradigm using tone and electrical foot shock and in a spatial reversal learning task to evaluate behavioral inflexibility. We also analyzed the myelin basic protein in different brain areas of high drinker (HD) and low drinker (LD) rats. The HD rats, which were characterized by a compulsive drinking behavior on SIP, had a reduced level of LI effect and increased behavioral inflexibility in the spatial reversal learning task in comparison to the LD group. Moreover, HD rats showed less myelination in the center of the corpus callosum, striatum, and amygdala in comparison to LD rats. These findings strengthen the validity of HD rats that were selected by SIP as a possible phenotype of compulsive neuropsychiatric disorders, as evidenced by the existence of behaviors and biological markers that are related to schizophrenia and obsessive-compulsive disorder, including a reduced LI effect, behavioral inflexibility and reduced brain myelination. Future studies could contribute to the elucidation of the mechanisms underlying the compulsive phenotype of HD rats and its relation to vulnerability to schizophrenia.

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“…Similarly, HD compulsive rats on SIP have also shown reduced serotonin 5-HT 2A receptor binding and alterations in 5-HT tone in comparison to LD rats. 39 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders

Navarro

Álvarez

Colomina

et al. 2016

Schizophrenia Bulletin

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“…Furthermore, impulsive SHR and RHA lines show compulsive drinking on a schedule-induced polydipsia (SIP) task (Ibias and Pellón, 2011; Moreno et al, 2010), whereas individual variation in SIP predicts impulsivity in delay-discounting (Cardona et al, 2011) and 5CSRTT (Moreno et al, 2012). Collectively, these findings demonstrate that impulsivity, in its various forms, is a vulnerability marker for the development of compulsive drug taking.…”

Section: Trait-like Impulsivity In Rodents: a Vulnerability Marker Ofmentioning

confidence: 99%

Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction

Jupp

Caprioli

Dalley

2013

Disease Models &Amp; Mechanisms

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Impulsivity describes the tendency of an individual to act prematurely without foresight and is associated with a number of neuropsychiatric co-morbidities, including drug addiction. As such, there is increasing interest in the neurobiological mechanisms of impulsivity, as well as the genetic and environmental influences that govern the expression of this behaviour. Tests used on rodent models of impulsivity share strong parallels with tasks used to assess this trait in humans, and studies in both suggest a crucial role of monoaminergic corticostriatal systems in the expression of this behavioural trait. Furthermore, rodent models have enabled investigation of the causal relationship between drug abuse and impulsivity. Here, we review the use of rodent models of impulsivity for investigating the mechanisms involved in this trait, and how these mechanisms could contribute to the pathogenesis of addiction.

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“…Thus, SIP serves as the prototype of so-called adjunctive behaviour (Falk, 1971; also referred to as interim behaviour: Staddon, 1977). In relation to ADHD, SIP successfully selects among experimental subjects those that display characteristics associated with excess behaviour (Riley & Wetherington, 1987; Gilpin et al, 2008) and other disorders associated with deficient impulse control (Cardona et al, 2006; López-Grancha et al, 2008), such as substance abuse (Myracle et al, 2005), obsessive compulsive behaviour (Plat et al, 2008; Van Kuyck et al, 2008; Moreno & Flores 2012; Moreno et al, 2012; Flores et al, 2014), and schizophrenia (Hawken et al 2011 a and b, 2013). …”

Section: Introductionmentioning

confidence: 99%

A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD

Íbias

Pellón

Sanabria

2015

Behavioural Brain Research

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Recent research has suggested that frequent short bursts of activity characterize hyperactivity associated with attention deficit hyperactivity disorder (ADHD). This study determined whether such pattern is also visible in schedule-induced polydipsia (SIP) in the spontaneously hypertensive rat (SHR), an animal model of ADHD. Male SHR, Wistar Kyoto (WKY) and Wistar rats were exposed to 40 sessions of SIP using a multiple fixed-time (FT) schedule of food delivery with FT 30-s and FT 90-s components. Stable performance was analysed to determine the extent to which SIP-associated drinking is organized in bouts. The Bi-Exponential Refractory Model (BERM) of free-operant performance was applied to schedule-induced licks. A model comparison analysis supported BERM as a description of SIP episodes: licks were not produced at a constant rate but organized into bouts within drinking episodes. FT 30-s induced similar overall licking rates, latencies to first licks and episode durations across strains; FT 90-s induced longer episode durations in SHRs and reduced licking rate in WKY and Wistar rats to nearly baseline levels. Across schedules, SHRs made more and shorter bouts when compared to the other strains. These results suggest an incentive-induced hyperactivity in SHR that has been observed in operant behavior and in children with ADHD.

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Poor inhibitory control and neurochemical differences in high compulsive drinker rats selected by schedule-induced polydipsia

Abstract: These findings show that HD rats selected by SIP exhibit compulsive and impulsive behaviour based on measures of performance on the five-choice serial reaction time task and associated with changes in monoaminergic systems in limbic-striatal circuitry.

Cited by 30 publications

References 63 publications

Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders

Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders

Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction

A microstructural analysis of schedule-induced polydipsia reveals incentive-induced hyperactivity in an animal model of ADHD

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