Sch 37224, an Experimental Antiallergy Compound, Inhibits the Neuropeptide Component of Hyperventilation- and Nicotine-Induced Bronchoconstriction in Guinea Pigs
Abstract:Sch 37224 is an experimental antiallergy coumpound that inhibits hyperventilation-induced bronchoconstriction (HIB) in guinea pigs and cold air bronchospasm in human asthmatics. HIB in guinea pigs may involve the release of tachykinins, such as neurokinin A (NKA) and substance P (SP), and the action of Sch 37224 in this model may relate to inhibition of these neuropeptides. We studied the effect of Sch 37224 on the neuropeptide component of HIB that was enhanced in guinea pigs treated with the neutral endopept… Show more
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