Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on hyperventilation-induced bronchoconstriction in the guinea pig

Corboz, Michel R.; Fernandez, Xiomara; Hey, John A.

doi:10.1016/j.pupt.2006.11.007

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…These results are supported by a recent study that showed an NK 2 selectivity pertaining to bronchial hyperreactivity and suggested an importance for capsaicin-sensitive nerves in bronchoconstriction in mice (Elekes et al, 2007). Another study found that NK 2 receptors played a predominant role in a guinea pig model of mechanically induced bronchoconstriction (Corboz et al, 2008). In contrast, protease-activated receptor-2-mediated, TTX-and capsaicinsensitive neurons in murine small intestine did not reveal differences in NK 1 versus NK 2 selectivity (Zhao and SheaDonohue, 2003), as we observed, which could possibly be explained by species differences between bovine and murine or tissue differences between bronchi and small intestine.…”

Section: Discussionsupporting

confidence: 79%

Involvement of the Neurokinin-2 Receptor in Airway Smooth Muscle Stretch-Activated Contractions Assessed in Perfused Intact Bovine Bronchial Segments

Hernandez

Cox²,

Janssen³

2008

J Pharmacol Exp Ther

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The airway response to deep inspirations (DIs) in asthmatics has been shown to be ineffective in producing bronchodilation and can even cause bronchoconstriction. However, the manner by which a DI is able to cause bronchoconstriction remains ambiguous. We sought to investigate the pathway involved in this stretch-activated contraction and whether this contraction is intrinsic to airway smooth muscle (ASM). In brief, intact bovine bronchial segments were dissected, and side branches were ligated and then mounted horizontally in an organ bath. Intraluminal pressure was measured under isovolumic conditions. Instantaneously opening and then closing the tap on a column of fluid 5 to 30 cm high evoked a sudden increase in intraluminal pressure (equivalent to the height of the column of fluid) followed by a stress relaxation response of the ASM. When tissues were stimulated with carbachol (10 Ϫ8 M) or serotonin (10 Ϫ7

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Section: Discussionsupporting

confidence: 79%