Sceletium tortuosum demonstrates in vitro anti-HIV and free radical scavenging activity

Kapewangolo, Petrina T.; Tawha, T.; Nawinda, Teopolina N.; Knott, Michael G.; Hans, Renate

doi:10.1016/j.sajb.2016.06.009

Cited by 26 publications

(13 citation statements)

References 23 publications

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“…Moreover, pepstatin (positive control) exhibited low binding free energies of −8.9 to −9.5 kcal/mol in 3 independent runs. Pepstatin has been used as positive control drug that exhibits anti-HIV properties through enzymatic assay 37 , 38 , and thus, pepstatin was included as a reference in a comparative analysis of molecular docking to determine the compound’s activity as an anti-HIV protease based on its potential binding affinity. The structures possessing the lowest binding free energy were visualized, and hydrogen bond analysis was conducted using the surface/binding analysis tool in UCSF Chimera version 1.11.…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies have reported the anti-HIV activity of several bioactive compounds derived from plant extracts 37 , 38 and mushroom 39 . The current study examined the anti-HIV activity of polygonumins A, and the compound’s potential activity was further evaluated to identify the potential interactions of the compound with mutant HIV-1 proteases through molecular docking simulation.…”

Section: Resultsmentioning

confidence: 99%

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Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities

Ahmad

Sahidin

Taher

et al. 2018

Sci Rep

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Polygonumins A, a new compound, was isolated from the stem of Polygonum minus. Based on NMR results, the compound’s structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure differences were located at C-3″″′. The cytotoxic activity of polygonumins A was evaluated on several cancer cell lines by a cell viability assay using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The compound showed the highest antiproliferative (p < 0.05) activities against K562 (Human Leukaemia Cell Line), MCF7 (Human breast adenocarcinoma cell line), and HCT116 (Colorectal cancer cells) cells. Cytotoxic studies against V79–4 cells were carried out and showed that polygonumins A was toxic at 50 µg/ml, suggesting that this compound may be used as an anticancer drug without affecting normal cells. Polygonumins A also showed promising activity as an HIV-1 protease inhibitor with 56% relative inhibition. Molecular docking results indicated that the compound possesses high binding affinity towards the HIV protease over the low binding free energy range of -10.5 to -11.3 kcal/mol. P. minus is used in Malaysian traditional medicine for the treatment of tumour cells. This is the first report on the use of P. minus as an HIV-1 protease inhibitor.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities

Ahmad

Sahidin

Taher

et al. 2018

Sci Rep

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show abstract

“…In addition, both extracts had also inhibited HIV-1 PR with IC 50 values < 100 μg/mL. Sceletium tortuosum might be a potential source of new lead compounds in the development of new anti-HIV compounds [ 67 ].…”

Section: Plant Extracts and Some Secondary Metabolites With Anti-hmentioning

confidence: 99%

Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

Salehi

Şener

et al. 2018

IJMS

124

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Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.

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“…Various plant species may hold potential as they have already been shown to alter CNS neurotransmission [ 281 ] and poses anti-COVID properties ( for detailed reviews, see Ahmad et al [ 282 ] and Khanna et al [ 283 ]). For example, Sceletium tortuosum may be of interest as it has mild anti-inflammatory properties, without hindering an adequate immune response to acute immune challenges [ 284 ], and also exerts antiretroviral effects by inhibiting HIV enzymes and proteases [ 285 ]. Mangosteen pericarp extract has been demonstrated to have antidepressant and procognitive properties in rodent models [ 286 ], as well as bolster the antipsychotic effects of haloperidol [ 286 , 287 ].…”

Section: Adjunctive Psychotropic Treatments During Sars-cov-2 Infectimentioning

confidence: 99%

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

Vuren

Steyn

Brink

et al. 2021

Biomedicine & Pharmacotherapy

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Sceletium tortuosum demonstrates in vitro anti-HIV and free radical scavenging activity

Cited by 26 publications

References 23 publications

Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities

Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities

Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

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