Scedosporium apiospermum as a rare cause of fungal rhinosinusitis

Baidya, Ankita; Gupta, Nitin; Basu, Ayan; Kodan, Parul; Aggarwal, Karan; Singh, Chirom Amit; Singh, Gagandeep; Soneja, Manish; Xess, Immaculata

doi:10.4103/jfmpc.jfmpc_434_18

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…It is acquired after inhalation of this organism into the lungs or paranasal sinus or after traumatic inoculation through the skin [2]. It most commonly causes mycetomas in immunocompetent people and is seen mostly in temperate climates [3]. In immunocompromised patients, Scedosporium spp.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Fungal Rhinosinusitis Caused by Scedosporium apiopermum

Naik

Bhatt

Richards

et al. 2020

Head and Neck Pathol

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Fungal rhinosinusitis (FRS) is inflammation of the paranasal sinus mucosa due to fungal infections, which can be invasive or non-invasive. The occurrence of a sphenoid mucocele with a fungal ball is rare. We report a case of sphenoid sinus mucocele with a fungal ball caused by Scedosporium apiopermum in a 32-year-old female who presented to the Emergency Department with persistent headache not relieved on medications. The radiological images showed a mucocele with clival osteomyelitis. Urgent endoscopic examination and debridement was undertaken which demonstrated a mucocele with fungal ball. Microbiological examination confirmed it to be Scedosporium apiopermum.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Fungal Rhinosinusitis Caused by Scedosporium apiopermum

Naik

Bhatt

Richards

et al. 2020

Head and Neck Pathol

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Epidemiology of rare bacterial, parasitic, and fungal pathogens in India

Sharma,

Krishnaswamy,

Chaturvedi

et al. 2024

IJID Regions

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Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

Neoh,

Chen,

Lanternier

et al. 2024

Clin Microbiol Rev

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SUMMARY Although Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal susceptibility, and treatment. An expansion of hosts at risk for these difficult-to-treat infections has emerged over the last two decades given the increased use of, and broader population treated with, immunomodulatory and targeted molecular agents as well as wider adoption of antifungal prophylaxis. Clinical presentations differ not only between genera but also across the different Scedosporium species. L. prolificans is intrinsically resistant to most currently available antifungal agents, and the prognosis of immunocompromised patients with lomentosporiosis is poor. Development of, and improved access to, diagnostic modalities for early detection of these rare mold infections is paramount for timely targeted antifungal therapy and surgery if indicated. New antifungal agents (e.g., olorofim, fosmanogepix) with novel mechanisms of action and less cross-resistance to existing classes, availability of formulations for oral administration, and fewer drug-drug interactions are now in late-stage clinical trials, and soon, could extend options to treat scedosporiosis/lomentosporiosis. Much work remains to increase our understanding of these infections, especially in the pediatric setting. Knowledge gaps for future research are highlighted in the review.

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Scedosporium apiospermum as a rare cause of fungal rhinosinusitis

Cited by 3 publications

References 8 publications

A Rare Case of Fungal Rhinosinusitis Caused by Scedosporium apiopermum

A Rare Case of Fungal Rhinosinusitis Caused by Scedosporium apiopermum

Epidemiology of rare bacterial, parasitic, and fungal pathogens in India

Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

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