A Rare Case of Fungal Rhinosinusitis Caused by Scedosporium apiopermum

Naik, Paresh; Bhatt, Kiranmai; Richards, Emma; Bates, Timothy; Jahshan, Forsan; Chavda, Swarupsinh; Ahmed, Shahzada

doi:10.1007/s12105-020-01248-7

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…7 A reporting pathologist needs to correlate the histopathology findings with microbiological diagnosis as an erroneous assumption of Aspergillus infection could lead to ineffective therapy with antifungal, and hence poor outcome. 8 Colony morphology on culture and sporulation by culture can help in differentiating Aspergillus species and Scedosporium species infection; however, it can also sometimes lead to confusion. 9 Hence, accurate identification of clinical isolates at the species level becomes of utmost importance as these species differ in their antifungal susceptibility pattern.…”

Section: Discussionmentioning

confidence: 99%

Time versus tissue: Timely identification of Scedosporium Rhinosinusitis in a post-COVID-19 case by MALDI-TOF MS leading to successful management

Rai¹,

Singh²,

Anand³

et al. 2022

Medical Journal Armed Forces India

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Section: Discussionmentioning

confidence: 99%

Time versus tissue: Timely identification of Scedosporium Rhinosinusitis in a post-COVID-19 case by MALDI-TOF MS leading to successful management

Rai¹,

Singh²,

Anand³

et al. 2022

Medical Journal Armed Forces India

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Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

Neoh,

Chen,

Lanternier

et al. 2024

Clin Microbiol Rev

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SUMMARY Although Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal susceptibility, and treatment. An expansion of hosts at risk for these difficult-to-treat infections has emerged over the last two decades given the increased use of, and broader population treated with, immunomodulatory and targeted molecular agents as well as wider adoption of antifungal prophylaxis. Clinical presentations differ not only between genera but also across the different Scedosporium species. L. prolificans is intrinsically resistant to most currently available antifungal agents, and the prognosis of immunocompromised patients with lomentosporiosis is poor. Development of, and improved access to, diagnostic modalities for early detection of these rare mold infections is paramount for timely targeted antifungal therapy and surgery if indicated. New antifungal agents (e.g., olorofim, fosmanogepix) with novel mechanisms of action and less cross-resistance to existing classes, availability of formulations for oral administration, and fewer drug-drug interactions are now in late-stage clinical trials, and soon, could extend options to treat scedosporiosis/lomentosporiosis. Much work remains to increase our understanding of these infections, especially in the pediatric setting. Knowledge gaps for future research are highlighted in the review.

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A Rare Case of Fungal Rhinosinusitis Caused by Scedosporium apiopermum

Cited by 2 publications

References 5 publications

Time versus tissue: Timely identification of Scedosporium Rhinosinusitis in a post-COVID-19 case by MALDI-TOF MS leading to successful management

Time versus tissue: Timely identification of Scedosporium Rhinosinusitis in a post-COVID-19 case by MALDI-TOF MS leading to successful management

Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

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