Scavenging Properties of Plant-Derived Natural Biomolecule Para-Coumaric Acid in the Prevention of Oxidative Stress-Induced Diseases

Roychoudhury, Shubhadeep; Sinha, Barnali; Choudhury, Birupakshya Paul; Jha, Niraj Kumar; Palit, Partha; Kundu, S. S.; Mandal, Subhash C.; Kolesárová, Adriana; Yousef, Mokhtar I.; Ruokolainen, Janne; Sláma, Petr; Kesari, Kavindra Kumar

doi:10.3390/antiox10081205

Cited by 37 publications

(26 citation statements)

References 78 publications

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“…Caffeic and chlorogenic acids did not show significant differences with respect to the CTR, except for the onion fertilized with SBORHP. p -coumaric and gallic acids are antioxidants with diverse physiological functions that are beneficial for human health with ascertained anticancer, anti-inflammatory, and antimicrobial properties [ 25 , 26 , 27 ]. The mechanisms of action of polyphenols are various and complex and depend on their chemical structures.…”

Section: Resultsmentioning

confidence: 99%

Phytochemicals from Red Onion, Grown with Eco-Sustainable Fertilizers, Protect Mammalian Cells from Oxidative Stress, Increasing Their Viability

et al. 2022

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Red onion, a species of great economic importance rich in phytochemicals (bioactive compounds) known for its medicinal properties, was fertilized with sulphur-bentonite enriched with orange residue or olive pomace, with the aim of producing onion enriched in health beneficial compounds. There is a worldwide great demand of minimally processed food or food ingredients with functional properties because of a new awareness of how important healthy functional nutrition is in life. Phytochemicals have the capacity to regulate most of the metabolic processes resulting in health benefits. Red onion bioactive compound quantity and quality can vary according to cultivation practices. The main aims of the current research were to determine the chemical characteristics of the crude extracts from red onion bulbs differently fertilized and to evaluate their biological activity in normal and oxidative stress conditions. The lyophilized onion bulbs have been tested in vitro on two cellular models, i.e., the H9c2 rat cardiomyoblast cell line and primary human dermal fibroblasts, in terms of viability and oxygen radical homeostasis. The results evidenced different phytochemical compositions and antioxidant activities of the extracts obtained from red onions differently fertilized. Sulphur-bentonite fertilizers containing orange waste and olive pomace positively affected the red onion quality with respect to the red onion control, evidencing that sulphur-bentonite-organic fertilization was able to stimulate plant a secondary metabolism inducing the production of phytochemicals with healthy functions. A positive effect of the extracts from red onions treated with fertilizers—in particular, with those containing orange waste, such as the reduction of oxidative stress and induction of cell viability of H9c2 and human fibroblasts—was observed, showing a concentration- and time-dependent profile. The results evidenced that the positive effects were related to the phenols and, in particular, to chlorogenic and p-coumaric acids and to the flavonol kaempferol, which were more present in red onion treated with low orange residue than in the other treated ones.

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Section: Resultsmentioning

confidence: 99%

Phytochemicals from Red Onion, Grown with Eco-Sustainable Fertilizers, Protect Mammalian Cells from Oxidative Stress, Increasing Their Viability

et al. 2022

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“…Moreover, other studies documented the improved oxidative status of male reproductive organs by C. intybus [ 86 , 87 ]. Coumaric [ 92 ], vanillic [ 89 , 90 , 93 , 94 ], and ferulic acids [ 89 , 91 , 95 , 96 ] are phenolic compounds which are widely dispersed in numerous plants and have been extensively investigated for their antioxidant property. In the same manner, C. endivia L. crude extract and the phenolic fraction demonstrated an anti-inflammatory action by decreasing NF-κB, IL-1 β , IL-6, and TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Potential Gonado-Protective Effect of Cichorium endivia and Its Major Phenolic Acids against Methotrexate-Induced Testicular Injury in Mice

et al. 2022

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Cichorium endivia L. (Asteraceae) is a wide edible plant that grows in the Mediterranean region. In this study, a phytochemical investigation of C. endivia L. ethanolic extract led to the isolation of stigmasterol (1), ursolic acid (2), β-amyrin (3), azelaic acid (4), vanillic acid (5), (6S, 7E)-6-hydroxy-4,7-megastigmadien-3,9-dione (S(+)-dehydrovomifoliol) (6), 4-hydroxy phenyl acetic acid (7), vomifoliol (8), ferulic acid (9), protocatechuic acid (10), kaempferol (11), p. coumaric acid (12), and luteolin (13). In addition, the total phenolic content as well as the in vitro antioxidant activity of C. endivia L. extract were estimated. Moreover, we inspected the potential gonado-protective effect of C. endivia crude extract, its phenolic fraction, and the isolated coumaric, vanillic, and ferulic acids against methotrexate (MTX)-induced testicular injury in mice. There were seven groups: normal control, MTX control, MTX + C. endivia crude extract, MTX + C. endivia phenolic fraction, MTX + isolated coumaric acid, MTX + isolated vanillic acid, and MTX + isolated ferulic acid. MTX was given by i.p. injection of a 20 mg/kg single dose. The crude extract and phenolic fraction were given with a dose of 100 mg/kg/day, whereas the compounds were given at a dose of 10 mg/kg/day. A histopathological examination was done. The testosterone level was detected in serum together with the testicular content of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), interleukin 1β (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB), B-cell lymphoma 2 (Bcl-2), Bcl-2 associated x protein (Bax), p53, and miR-29a. C. endivia crude extract, the phenolic fraction, and the isolated compounds showed significant elevation in their levels of testosterone, CAT, SOD, Bcl-2 with a significant decrease in their levels of MDA, TNF-α, IL-1β, IL-6, NF-κB, Bax, P53, and miR-29a compared to those of the MTX control group. In conclusion, C. endivia mitigated MTX-induced germ cell toxicity via anti-inflammatory, antioxidant, and antiapoptotic effects.

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“…Many current studies reported that para coumaric acid elevates the level or the activity of enzymes that decrease oxidative stress and inflammation [25][26][27]. By inhibiting NF-kB gene which act as transcription factors of pro-inflammatory cytokines, para coumaric acid acts as an anti-inflammatory agent [28]. This could explain the ethnobotanical usage of P. syriaca against many inflammatory diseases.…”

Section: Zhan and Whangmentioning

confidence: 95%

Preliminary Analysis of Phenolic Acid Composition of Phlomis syriaca

Kepekçi

Pehlivan

2021

Glob. J. Bot. Sci.

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Phlomis genus is one of the genera of Lamiacea family with various pharmaceutical activity. Although phythochemical constituents and pharmacological activities of most of the Phlomis genus are well documented, there is a scarce of research on Phlomis syriaca. This study was performed to reveal phenolic acids of P. syriaca inorder to encourage more studies based on its phytochemicals to elucidate the pharmacalogical activity of this plant. Total phenolic compound amount of P. syriaca was detected as 48.46 ± 4.30 μg GAEs/mg extract according to Folin– Ciocalteu method. An HPLC method was developed to quantify the amounts of nine phenolic compounds in the methanol extract of P.syriaca. The developed analytical system led to the separation, identification and the quantification of nine phenolic compounds most frequently found in plants belonging to the Lamiaceae family. The phenolic acids with determined concentrations in descending order were as follows, respectively; p-coumaric acid (5.334 mg/L), caffeic acid (2.367 mg/L), 4-hydroxybenzoic acid (1.978 mg/L), ferulic acid (1. 052 mg/L), chlorogenic acid (0.581 mg/L), rosmarinic acid (0.546 mg/L), protocautechic acid (0.287 mg/L), gallic acid (0.186 mg/L). cinamic acid (0.064 mg/L).

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Scavenging Properties of Plant-Derived Natural Biomolecule Para-Coumaric Acid in the Prevention of Oxidative Stress-Induced Diseases

Cited by 37 publications

References 78 publications

Phytochemicals from Red Onion, Grown with Eco-Sustainable Fertilizers, Protect Mammalian Cells from Oxidative Stress, Increasing Their Viability

Phytochemicals from Red Onion, Grown with Eco-Sustainable Fertilizers, Protect Mammalian Cells from Oxidative Stress, Increasing Their Viability

Potential Gonado-Protective Effect of Cichorium endivia and Its Major Phenolic Acids against Methotrexate-Induced Testicular Injury in Mice

Preliminary Analysis of Phenolic Acid Composition of Phlomis syriaca

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