Scarless wound healing gel with Binahong (Anredera cordifolia (Ten) Steenis) leaves extract and celecoxib as the active ingredients

Istyastono, Enade Perdana; Yuliani, Sri Hartati

doi:10.1063/1.4958594

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…Firstly, we demonstrated that COX-2 and TGF Beta-1 showed similar cellular profiles as both were expressed mainly by the infiltrating inflammatory cells in the wound area, this was in line with other studies [52][53][54][55], however, we endorsed our finding by showing for the first time actual colocalization of Cox-2 and TGF Beta-1 on the cellular level in the wound area. Secondarily, demonstrating that both mediators showed a similar pattern of expression in the wound, where COX-2 upregulation and downregulation was associated with a concomitant similar change in TGF Beta-1, this was in line with other studies in different animal models of inflammation [61][62][63][64][65][66][67][68][69][70]. Thirdly, we endorsed this COX-2 and TGF Beta-1 coordinated relation results further by a correlation studies that showed for the first time a strong correlation between COX-2 and TGF Beta-1 in dermal wounds.…”

Section: Discussionsupporting

confidence: 88%

Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

El-Aleem¹,

Jude²

2017

J Cytol Histol

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Background: Wound healing is a highly ordered dynamic process associated with inflammation at early stages and with permanent scarring at late stages. Scars could be disfiguring and could advance to be hypertrophic or keloid scars, this would have a strong physical and psychological impact on the patients afterward. The role of inflammatory mediators which could be pro-or anti-inflammatory, pro-or -anti fibrotic was the focus of wound healing research for decades and the balance between them is the key factor determining the outcome of healing.

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Section: Discussionsupporting

confidence: 88%

Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

El-Aleem¹,

Jude²

2017

J Cytol Histol

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“…Tumbuhan yang dapat ditemui di alam bebas di hutan tropis Indonesia banyak dilaporkan mengandung senyawa aktif seperti antioksidan, antitoksik, bahan penyembuh luka, dan aktivitas lainnya. 1,2 Dalam beberapa dekade ini, penelitian mengenai pengembangan proses isolasi senyawa penyembuh luka mulai marak dikembangkan. 3 Salah satu tumbuhan khas yang terdapat di hutan tropis Indonesia adalah hasil ekstraksi daun Binahong atau yang memiliki nama latin (Anredera cordifolia (Ten) Steenis).…”

Section: Pendahuluanunclassified

“…Steenis). 2,6 Kandungan kimia daun binahong pada penelitian sebelumya telah dilaporkan bahwa terdapat kandungan saponin, alkaloid, terpenoid dan flavonoid. 7 Senyawa-senyawa kimia daun binahong diduga dapat membantu proses penyembuhan luka yaitu asam askorbat, saponin alkaloid dan flavonoid.…”

Section: Pendahuluanunclassified

Isolation and Characterization of Wound Healing Compounds from Chloroform Extract of Binahong Leaves (Anredera cordifolia (Ten.) Steenis)

Rohani

Purwoko

2021

magnamed

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The leaves of Binahong (Anredera cordifolia (Ten) Steenis) have been widely studied to have benefits and uses in various medical purposes, one of which is in the wound healing process. The existence of several active compounds contained in the leaves of the Binahong tree plant have an important role in wound healing, such as flavonoids, terpenoids, alkaloids, saponins, ascorbic acid and citrate compounds, these compounds are the targeted for further process of this natural product. The eminence of the extraction method that is used repeatedly and consistently to obtain pure compounds from Binahong leaves to be isolated is the one of topics discussed in this literature study. The perspective of implementation from liquid-solid extraction followed by liquid-liquid extraction using chloroform as a solvent is discussed comprehensively in this article. The identification of the isolation of compounds are able to conducted by implemented a thin layer chromatography (TLC) techniques, and for the further structural determination by UV, MS, FTIR, NMR spectroscopy and separation techniques using GC-MS. Respectively, the components are successfully to be identified and reported in previous research, for the following criteria that have been completed, some isolated active compound are purposed as the candidate for the wound healing agent. For the further application it is reasonable to implied these matters for some pharmaceutical products.

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“…Anredera cordifolia is a well-recognized medicinal plant that belong to Basellaceae family. A. cordifolia possesses pharmacological activities such as antibacterial [16], gastroprotective [17], antivirus [18], antidiabetic [19], antiinflammatory [20], wound healing [21] and antioxidant [22]. Phytochemical screening has revealed the presence of flavanols [18], glycosides, alkaloids [23], flavonoids [24], saponin and steroid [19] in different parts.…”

Section: Introductionmentioning

confidence: 99%

Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activities

Nxumalo

Ngidi

Shandu

et al. 2020

BMC Complement Med Ther

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Background Endophytes, especially those that are found from ethnopharmacologically noteworthy medicinal plants have attracted attention due to their diverse bioactive metabolites of pharmacological importance. Methods This study aimed at isolating endophytic bacterium from the leaves of Anredera cordifolia CIX1 for its bioactive metabolites. The endophytic isolates were identified by 16S rRNA sequence and investigated for antibiotic sensitivity using different antibiotics. The secondary metabolites were evaluated for antibacterial activity against four bacterial strains. The 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis (3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods were used to assess their scavenging activities. The chemical components were analysed by gas chromatography-mass spectrometry (GC-MS). Results Out of 13 isolates, Isolate 1 was identified as Pseudomonas aeruginosa CP043328.1. It was resistant to clindamycin, ertapenem, penicillin G, amoxicillin, cephalothin and kanamycin but sensitive to imipenem, meropenem, and gentamycin. Its extract demonstrated antibacterial activity with minimum inhibitory concentration value of 0.098 against Bacillus cereus (ATCC 10102) and Staphylococcus aureus (ATCC 25925) and 0.391 mg/ml against Escherichia coli (ATCC 25922) and Proteus mirabilis (ATCC 25933). The extract revealed DPPH and ABTS scavenging activities with half maximal inhibitory concentration value of 0.650 mg/ml and 0.15 mg/ml, respectively. The GC-MS revealed a total of 15 compounds with diisooctyl phthalate (50.51%) and [1, 2, 4] oxadiazole, 5-benzyl-3 (10.44%) as major components. Conclusions P. aeruginosa CP043328.1 produced secondary metabolites with antibacterial and antioxidant activities.

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Scarless wound healing gel with Binahong (Anredera cordifolia (Ten) Steenis) leaves extract and celecoxib as the active ingredients

Cited by 12 publications

References 12 publications

Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

Isolation and Characterization of Wound Healing Compounds from Chloroform Extract of Binahong Leaves (Anredera cordifolia (Ten.) Steenis)

Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activities

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