SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner

Stanislovaitienė, Daiva; Lesauskaitė, Vaiva; Žaliūnienė, Dalia; Smalinskienė, Alina; Gustienė, Olivija; Žaliaduonytė-Pekšienė, Diana; Tamošiūnas, Abdonas; Lukšienė, Dalia; Petkevičienė, Janina; Žaliūnas, Remigijus

doi:10.1186/1476-511x-12-24

Cited by 27 publications

(36 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the single nucleotide polymorphisms (SNPs) in the SCARB1 gene is rs5888 SNP, which was initially found by Acton 17, a “C” to “T” substitution at cDNA position 1050 base position on exon 8. The rs5888 SNP T allele has been associated with increased serum HDL-C levels and decreased risk of atherosclerosis related diseases 24-28. In our previous studies, however, we found that the rs5888 SNP T allele was associated with decreased HDL-C levels and increased TC, LDL-C and ApoB levels in three Guangxi populations 29,30.…”

Section: Introductioncontrasting

confidence: 51%

“…In LDL receptor-deficient mice, attenuated expression of SCARB1 was associated with increased LDL-C and accelerated atherosclerosis 14,15. The association of several variants in the SCARB1 gene and serum lipid profiles has been reported in diverse populations 16-28. One of the single nucleotide polymorphisms (SNPs) in the SCARB1 gene is rs5888 SNP, which was initially found by Acton 17, a “C” to “T” substitution at cDNA position 1050 base position on exon 8.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Scavenger Receptor Class B Type 1 Gene rs5888 Single Nucleotide Polymorphism and the Risk of Coronary Artery Disease and Ischemic Stroke: A Case-Control Study

Wu¹,

Yin²,

Cao³

et al. 2013

Int. J. Med. Sci.

View full text Add to dashboard Cite

Background: Our previous studies have showed that the rs5888 single nucleotide polymorphism (SNP) in Scavenger receptor class B type 1 (SCARB1) gene is associated with serum lipid levels in the general Chinese populations. The present study was undertaken to detect the associations between rs5888 SNP and the risk of coronary artery disease (CAD) and ischemic stroke (IS).Methods: A total of 1,716 unrelated subjects (CAD, 601; IS, 533; and healthy controls, 582) were included in this study. Genotyping of the rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism.Results: The genotypic frequencies of SCARB1 rs5888 SNP were different between CAD patients and controls, the subjects with TT genotype had high risk of CAD (OR = 1.76, P = 0.038 for TT vs. CC; and OR = 1.75, P = 0.036 for TT vs. CC/CT). There was no significant association between genotypes and the risk of IS. Further analysis showed that the subjects with TT genotype in the total population had lower levels of high-density lipoprotein cholesterol than the subjects with CC/CT genotypes (P < 0.05), the subjects with TT genotype in controls but not in CAD or IS patients had higher levels of serum LDL-C and ApoB than those with CC genotype (P < 0.05 for each).Conclusions: The present study suggests that the SCARB1 rs5888 SNP influences serum lipid levels, and is associated with the risk of CAD.

show abstract

Section: Introductioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Scavenger Receptor Class B Type 1 Gene rs5888 Single Nucleotide Polymorphism and the Risk of Coronary Artery Disease and Ischemic Stroke: A Case-Control Study

Wu¹,

Yin²,

Cao³

et al. 2013

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…A recent study showed that lipid-associated loci arestrongly associated with other components of the metabolic syndrome, including SBP and DBP with excess associations of 2.5-fold and 3.7-fold[5], respectively. We ignored the possible modulation of gene-age interactions by gender[16-17]and adjusted for the use of lipid-altering medications through a dichotomous (yes/no) covariate; this crude adjustment ignored both the dosage (which is not available in this study) and exact medication taken.…”

Section: Discussionmentioning

confidence: 99%

Linkage analysis incorporating gene–age interactions identifies seven novel lipid loci: The Family Blood Pressure Program

et al. 2014

View full text Add to dashboard Cite

OBJECTIVE To detect novel loci with age-dependent effects on fasting (≥8 hours) levels of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides using3,600 African Americans, 1,283 Asians, 3,218 European Americans, and 2,026 Mexican Americans from the Family Blood Pressure Program (FBPP). METHODS Within each subgroup (defined by network, race, and sex), we employedstepwise linear regression (retention p≤0.05) to adjust lipid levels for age, age-squared, age-cubed,body-mass-index, current smoking status, current drinking status, field center, estrogen therapy (females only), as well asantidiabetic, antihypertensive, and antilipidemic medication use. For each trait, we pooled the standardized male and female residuals within each network and race and fit a generalized variance components model that incorporated gene-age interactions. We conducted FBPP-wide and race-specific meta-analyses by combining the p-values of each linkage marker across subgroups usinga modifiedFisher's method. RESULTS We identified seven novel loci with age-dependent effects; four total cholesterol loci from the meta-analysis of Mexican Americans (on chromosomes 2q24.1, 4q21.21, 8q22.2, and 12p11.23) and three high-density lipoprotein loci from the meta-analysis of all FBPP subgroups (on chromosomes 1p12, 14q11.2, and 21q21.1). These loci lacked significant genome-wide linkage or association evidence in the literature and hadlogarithm of odds (LOD) score ≥ 3 in the meta-analysis with LOD≥1 in at least two network and race subgroups (exclusively of non-European descent). CONCLUSION Incorporating gene-age interactions into the analysis of lipids using multi-ethnic cohorts can enhance gene discovery. These interaction loci can guide the selection of familiesfor sequencingstudies of lipid-associated variants.

show abstract

“…Several studies have shown that a rare T variant was associated with an atheroprotective lipid profile in men but not in women [9,13]. A previous study carried out in Lithuania revealed that men aged 65–74 who were carriers of the TT genotype had a higher level of HDL-C and a lower risk of myocardial infarction as compared to the CC genotype [31]. Gender and age-specific effects on blood lipid profiles were also demonstrated by other investigators [12,13,15].…”

Section: Discussionmentioning

confidence: 99%

Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults

et al. 2013

Self Cite

View full text Add to dashboard Cite

BackgroundDyslipidemia is one of several known risk factors for coronary heart disease, a leading cause of death in Lithuania. Blood lipid levels are influenced by multiple genetic and environmental factors. Epidemiological studies demonstrated the impact of nutrition on lipid levels within the Lithuanian population although the role of genetic factors for dyslipidemias has not yet been studied. The objective of this study was to assess the distribution of the APOE, SCARB1, PPARα genotypes in the Lithuanian adult population and to determine the relationship of these genotypes with dyslipidemia.MethodsA cross-sectional health survey was carried out in a representative random sample of the Lithuanian population aged 25–64 (n=1030). A variety of single-nucleotide polymorphisms (SNPs) of the APOE (rs429358 and rs7412), SCARB1 (rs5888) and PPARα (rs1800206) genes were assessed using real-time polymerase chain reaction. Serum lipids were determined using enzymatic methods.Results/Principal findingsMen and women with the APOE2 genotype had the lowest level of total and low-density lipoprotein cholesterol (LDL-C). Men with the APOE2 genotype had significantly higher levels of triglycerides (TG) than those with the APOE3 genotype. In men, the carriers of the APOE4 genotype had higher odds ratios (OR) of reduced (<1.0 mmol/L) high density lipoprotein cholesterol (HDL-C) levels versus APOE3 carriers (OR=1.98; 95% CI=1.05-3.74). The odds of having elevated (>1.7 mmol/L) TG levels was significantly lower in SCARB1 genotype CT carriers compared to men with the SCARB1 genotype CC (OR=0.50; 95% CI=0.31-0.79). In men, carriers of the PPARα genotype CG had higher OR of elevated TG levels versus carriers of PPARα genotype CC (OR=2.67; 95% CI=1.15-6.16). The odds of having high LDL-C levels were lower in women with the APOE2 genotype as compared to APOE3 genotype carriers (OR=0.35; 95% CI=0.22-0.57).Conclusions/SignificanceOur data suggest a gender difference in the associations between APOE, SCARB1, PPARα genotypes and lipid levels. In men, the APOE4 genotype and PPARα genotype CG were correlated with an atherogenic lipid profile while the SCARB1 genotype CT had an atheroprotective effect. In women, APOE2 carriers had the lowest odds of high LDL-C.

show abstract

SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner

Cited by 27 publications

References 33 publications

Scavenger Receptor Class B Type 1 Gene rs5888 Single Nucleotide Polymorphism and the Risk of Coronary Artery Disease and Ischemic Stroke: A Case-Control Study

Scavenger Receptor Class B Type 1 Gene rs5888 Single Nucleotide Polymorphism and the Risk of Coronary Artery Disease and Ischemic Stroke: A Case-Control Study

Linkage analysis incorporating gene–age interactions identifies seven novel lipid loci: The Family Blood Pressure Program

Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults

Contact Info

Product

Resources

About