Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions

Amini-Nik, Saeid; Yousuf, Yusef; Jeschke, Marc G.

doi:10.1016/j.addr.2017.07.017

Cited by 89 publications

(65 citation statements)

References 363 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3A) [135,136]. Fibrotic lesions can develop in all organs such as scars in skin, fibrosis of lungs, heart, kidneys, and liver [135][136][137]. Fibrosis hampers tissue function and eventually leads to organ failure.…”

Section: Mechanisms Of Matrix Accumulation In Fibrosismentioning

confidence: 99%

The extracellular matrix as a multitasking player in disease

2019

View full text Add to dashboard Cite

Extracellular matrices (ECMs) are highly specialized and dynamic three‐dimensional (3D) scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar components, such as collagens, fibronectin, and elastin, and non‐fibrillar molecules as proteoglycans, hyaluronan, and glycoproteins including matricellular proteins. These macromolecular components are interconnected forming complex networks that actively communicate with cells through binding to cell surface receptors and/or matrix effectors. ECMs exert diverse roles, either providing tissues with structural integrity and mechanical properties essential for tissue functions or regulating cell phenotype and functions to maintain tissue homeostasis. ECM molecular composition and structure vary among tissues, and is markedly modified during normal tissue repair as well as during the progression of various diseases. Actually, abnormal ECM remodeling occurring in pathologic circumstances drives disease progression by regulating cell–matrix interactions. The importance of matrix molecules to normal tissue functions is also highlighted by mutations in matrix genes that give rise to genetic disorders with diverse clinical phenotypes. In this review, we present critical and emerging issues related to matrix assembly in tissues and the multitasking roles for ECM in diseases such as osteoarthritis, fibrosis, cancer, and genetic diseases. The mechanisms underlying the various matrix‐based diseases are also discussed. Research focused on the highly dynamic 3D ECM networks will help to discover matrix‐related causative abnormalities of diseases as well as novel diagnostic tools and therapeutic targets.

show abstract

Section: Mechanisms Of Matrix Accumulation In Fibrosismentioning

confidence: 99%

The extracellular matrix as a multitasking player in disease

2019

View full text Add to dashboard Cite

show abstract

“…Also, laser therapy is another common clinical mean for HSs treatment. It has been proved that long‐pulsed Nd: YAG laser and pulsed dye laser play therapeutic roles in shallowing the colour, reducing the thickness and tension of HSs, and relieving symptoms such as pain and pruritus . Surgical excision is also a highly recommended measure for surgeons.…”

Section: The Classical Therapy Of Laser and Surgery With Corticosteroidsmentioning

confidence: 99%

“…It has been proved that long-pulsed Nd: YAG laser and pulsed dye laser play therapeutic roles in shallowing the colour, reducing the thickness and tension of HSs, and relieving symptoms such as pain and pruritus. 24 Surgical excision is also a highly recommended measure for surgeons. Surgery always combined with corticosteroid injection or radiotherapy in the clinic.…”

Section: The Classical Therapy Of Laser and Surgery With Corticostementioning

confidence: 99%

Biological approaches for hypertrophic scars

Zhong

2019

International Wound Journal

View full text Add to dashboard Cite

Scar formation is usually the pathological consequence of skin trauma. And hypertrophic scars (HSs) frequently occur in people after being injured deeply. HSs are unusually considered as the result of tissue contraction and excessive extracellular matrix component deposition. Myofibroblasts, as the effector cells, mainly differentiated from fibroblasts, play the crucial role in the pathophysiology of HSs. A number of growth factors, inflammatory cytokines involved in the process of HS occurrence. Currently, with in‐depth exploration and clinical research of HSs, various creative and effective treatments budded. In here, we summarize the progress in the molecular mechanism of HSs, and review the available biotherapeutic methods for their pathophysiological characteristics. Additionally, we further prospected that the comprehensive therapy may be more suitable for HS treatment.

show abstract

“…; Amini‐Nik et al. ). Some of the challenges include limited skin grafts availability, high costs, and large wound sizes.…”

Section: Introductionmentioning

confidence: 99%

Examining the contribution of surrounding intact skin during cutaneous healing

2019

Self Cite

View full text Add to dashboard Cite

Severe cutaneous wounds expose the body to the external environment, which may lead to impairments in bodily functions and increased risk of infection. There is a need to develop skin substitutes which could effectively promote complete skin regeneration following an injury. Murine models are used to test such skin substitutes, but their healing involves contraction of the dermis not found in human wounds. We have previously described a device called a dome, which comes in two models, that is used to prevent skin contraction in mice. One model provides a physical barrier to minimize contraction, and the other model has additional perforations in the barrier to allow cellular contribution from the surrounding intact skin. Taking advantage of an enhanced version of these two models, we compared granulation tissue formation, the extent of vascularization, and the transition to myofibroblastic phenotype between the models. We enhanced the dome by developing a twist open cap dome and applied the two models of the dome into the excisional wound biopsy in mice. We demonstrate that the dome can be used to prevent skin contraction in mice. The control model prevented skin contraction while barricading the contribution of surrounding intact skin. When not barricaded, the intact skin enhances wound healing by increasing the number of myofibroblasts and neovascularization. Using a novel model of inhibition of skin contraction in rodents, we examined the contribution from the surrounding intact skin to granulation tissue formation, myofibroblastic differentiation, and neovascularization during the course of skin healing in mice.

show abstract

Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions

Cited by 89 publications

References 363 publications

The extracellular matrix as a multitasking player in disease

The extracellular matrix as a multitasking player in disease

Biological approaches for hypertrophic scars

Examining the contribution of surrounding intact skin during cutaneous healing

Contact Info

Product

Resources

About