SCAPIS Pilot Study: Sitness, Fitness and Fatness— Is Sedentary Time Substitution by Physical Activity Equally Important for Everyone’s Markers of Glucose Regulation?

Abstract

Background: Although moderate-to-vigorous physical activity (MVPA) is mainly

Substituting Sedentary Time With Light and Moderate to Vigorous Physical Activity is Associated With Better Cardiometabolic Health

“…One other study including isotemporal substitution performed additional analyses adjusting for estimated VO2max and also found no significant change in point estimates [10]. Another study examining markers of glucose regulation explored the effects in high and low fit participants and suggested that low fit participants might benefit more from replacing sedentary time with active behavior [12].…”

“…Results from previous research clearly state that substituting sedentary time with MVPA will lead to lower clustered cardio-metabolic health risk, than substituting with LPA or sleep. Nonetheless, some uncertainty remains whether substituting sedentary time with LPA will already have positive results; or whether only substitution with higher intensities such as MVPA have beneficial results [8][9][10]12]. Furthermore, only a few authors included behaviors, such as LPA or MVPA [8,13].…”

Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients

“…Replacing sedentary time with LIPA was associated with a 3.0% lower fasting insulin values and a 3.1% lower insulin resistance, using the homeostatic model assessment (HOMA-IR) (Ekblom-Bak et al, 2016). Healy et al (2011) have previously documented that breaking up sedentary time may be associated with favorable changes in the cardio-metabolic and inflammatory risk profile in adults.…”

“…Understanding if the associations between breaks in sedentary time (BST) and metabolic indicators remain while in free-living conditions is still unknown. Moreover, patients with lower fitness and high fasting glucose levels benefited more from replacing the same amount of sedentary time with LIPA and MVPA, compared with participants with normal to high cardiorespiratory fitness levels (CRF) (Ekblom-Bak et al, 2016). Additionally, CRF seems to be positively associated with glycemic control (Rohling et al, 2016), and may be an important mediator in the relationship between sedentary behavior and MVPA with metabolic outcomes (Rohling et al, 2016).…”

Using Digital Health Technologies to Understand the Association Between Movement Behaviors and Interstitial Glucose: Exploratory Analysis (Preprint)

“…A recent study from the UK Biobank assessed whether the relationship between physical activity and mortality was modified by grip strength or cardiorespiratory fitness and concluded that those with the lowest strength or fitness had the most to gain from interventions [26]. Additionally, when adjusting sedentary time for either light activity or MVPA, those with lower fitness (Women < 32 & men < 35 ml/kg/min) and higher glucose (≥ 6.1 mmol/L) benefited more than high fitness participants, even after adjustment for sex, age, educational level, smoking and psychosocial stress [27]. These findings appear to support the hypothesis that whilst those with lower fitness may see daily differences in their glucose as a result of physical activity, those of higher fitness may keep their glucose concentrations within healthy ranges as a result of physiological adaptions, such as changes in insulin sensitivity [28,29].…”