Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients

Sardinha, Luís B.; Magalhães, João P.; Santos, Diana A.; Júdice, Pedro B.

doi:10.3389/fphys.2017.00262

Cited by 44 publications

(41 citation statements)

References 63 publications

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“…Nonetheless, lower fasting glucose and the dawn phenomenon in response to Condition 3 could reflect improved insulin sensitivity . Observational and experimental studies have already reported that breaks in sedentary time improve insulin homeostasis .…”

Section: Discussionmentioning

confidence: 99%

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Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night‐time glucose in Type 2 diabetes

et al. 2018

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Aim To explore the dose–response between frequency of interruption of sedentary time and basal glucose (fasting glucose, the dawn phenomenon and night‐time glucose) in Type 2 diabetes. Methods In a randomized three‐treatment, two‐period balanced incomplete block trial, 12 people with Type 2 diabetes (age, 60.0 ± 3.2 years; BMI, 30.2 ± 1.4 kg/m2) completed two of three conditions: sitting for 7 h interrupted every 60 min (Condition 1), 30 min (Condition 2), and 15 min (Condition 3) by 3‐min light‐intensity walking breaks. The activPAL3 and FreeStyle Libre were used to assess physical activity/sedentary behaviour and continuous glucose profile. Standardized meals were provided, and changes in basal glucose of the nights and early mornings before and after treatment conditions were calculated (mean ± SE). Results After treatment conditions, fasting glucose and duration of the dawn phenomenon were lower for Condition 3 (−1.0 ± 0.2 mmol/l, P < 0.02; −3.1 ± 1.3 h, P = 0.004) compared with Condition 1 (−0.1 ± 0.2 mmol/l; 1.9 ± 1.2 h). The magnitude of the dawn phenomenon was reduced in Condition 3 (−0.6 ± 0.4 mmol/l, P = 0.041) compared with Condition 2 (0.6 ± 0.3 mmol/l). Night‐time glycaemic variability (coefficient of variation) was reduced in Condition 3 (−9.7 ± 3.9%) relative to Condition 2 (6.1 ± 4.8%, P < 0.03) and Condition 1 (2.5 ± 1.8%, P = 0.02). There was no change in night‐time mean glucose. Conclusions Frequent interruptions of prolonged sitting with 3 min of light‐intensity walking breaks every 15 min improves fasting glucose, the dawn phenomenon and night‐time glycaemic variability, and this might be a simple therapeutic intervention to improve glucose control. Clinicaltrials.gov Identifier: NCT02738996

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Section: Discussionmentioning

confidence: 99%

“…There is evidence that sedentary time is associated with high fasting glucose, insulin resistance and metabolic risk profile . By contrast, breaks in sedentary time have a beneficial effect on metabolic risk profile and postprandial glucose, and this beneficial effect might extend to basal glucose control .…”

Section: Introductionmentioning

confidence: 99%

Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night‐time glucose in Type 2 diabetes

et al. 2018

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“…Most studies on the SB of T2DM patients found that SB is associated with abnormal glucose metabolism and metabolic risk factors and concluded that SB has a high correlation with the risk of cardiovascular disease mortality [11][12][13]. A study reported that SB was significantly correlated with body mass index (BMI) and waist circumference [14], and another study emphasized that the number of breaks in sedentary time (ST) should be increased to prevent central obesity [15].…”

Section: Introductionmentioning

confidence: 99%

“…13.3%) were in their 40's, 47 (39.3%) in 50's, 43 (35.8%) in 60's, 13 (10.8%) in 70's, and one (0.8%) in 80's. The mean age of study subjects was 59.3 years.…”

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confidence: 96%

Body Fat Is Related to Sedentary Behavior and Light Physical Activity but Not to Moderate-Vigorous Physical Activity in Type 2 Diabetes Mellitus

Han

Sohn

et al. 2020

Diabetes Metab J

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Background: Sedentary behavior (SB) has emerged as a new risk factor for cardiovascular accidents. We investigated whether physical activity levels or SB were related to percent body fat (%BF) in type 2 diabetes mellitus (T2DM). Methods: In this cross sectional study, we measured the duration of SB, light physical activity (LPA), moderate to vigorous physical activity (MVPA), total energy expenditure, and step counts using a wireless activity tracker (Fitbit HR; FB) for 7 days in freeliving conditions, along with %BF using a bio impedance analyzer (Inbody; Biospace) in 120 smartphone users with T2DM. Subjects were divided into exercise (Exe, n=68) and non-exercise (nonExe, n=52) groups based on self-reports of whether the recommended exercises (30 min/day, 3 days/week for 3 months) were performed. SBt, LPAt, MVPAt were transformed from SB, LPA, MVPA for normally distributed variables. Results: Participants were: female, 59.2%; age, 59.3±8.4 years; body mass index, 25.5±3.4 kg/m 2 ; glycosylated hemoglobin (HbA1c), 7.6%±1.2%; %BF, 30.4%±7.1%. They performed SB for 15.7±3.7 hr/day, LPA for 4.4±1.7 hr/day, and MVPA for 0.9±0.8 hr/day. The %BF was related to SBt and LPAt, but not to MVPA after adjustments for age, gender, and HbA1c. VPA was significantly higher in the Exe group than in the nonExe group, but SB, LPA, and moderate physical activity were not different. Predicted %BF was 89.494 to 0.105 (age),-13.047 (gender),-0.507 (HbA1c),-7.655 (LPAt) (F[4, 64]=62.929, P<0.001), with an R 2 of 0.785 in multiple linear regression analysis. Conclusion: Reduced body fat in elderly diabetic patients might be associated with reduced inactivity and increased LPA.

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“…As for metabolic function, sedentary behavior causes the deterioration of glycemic control [5] and an increased risk of type 2 diabetes (T2D) [6]. Previous research showed that an increase in the amount of time spent in daily sedentary behavior caused poor glycemic control in T2D patients [7]. On the other hand, in individuals with type 1 diabetes (T1D), the association between sedentary behavior and health outcomes is unclear.…”

Section: Introductionmentioning

confidence: 99%

Impact of Self-Reported Sitting Time and Transtheoretical Model Based on Exercise Behavior Change on Glycemic and Weight Control in Japanese Adults with Type 1 Diabetes: A Cross-Sectional Study

et al. 2020

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This cross-sectional study aimed to examine the associations among self-reported sitting time (ST), transtheoretical model (TTM) based on exercise behavior change, and glycemic and weight control in Japanese adults with type 1 diabetes (T1D). Forty-two adults (age, 44.0 (33.3–56.8) years) with uncomplicated T1D answered questions regarding their lifestyles, including ST per day, and TTM using self-administered questionnaires. The glycated hemoglobin (HbA1c) level correlated with age and ST (p < 0.05, p < 0.01, respectively), whereas body mass index correlated with duration of T1D and TTM (p < 0.05, p < 0.01, respectively). Logistic regression analysis showed that poor glycemic control (HbA1c, >7%) was associated with ST (odds ratio, 3.53 (95% confidence interval, 1.54–8.11), p < 0.01). In addition, the cut-off points for quartiles of ST were 4.6, 6.0, and 8.0 h/day, and the HbA1c level in the lowest quartile was 15% lower than that in the highest quartile (p < 0.01). Although further studies with larger samples are needed, these results implied that expanded self-reported ST might be related to poor glycemic control in Japanese T1D adults, most of whom were lean, young and middle-aged, regardless of TTM based on exercise behavior change.

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Sedentary Patterns, Physical Activity, and Cardiorespiratory Fitness in Association to Glycemic Control in Type 2 Diabetes Patients

Cited by 44 publications

References 63 publications

Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night‐time glucose in Type 2 diabetes

Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night‐time glucose in Type 2 diabetes

Body Fat Is Related to Sedentary Behavior and Light Physical Activity but Not to Moderate-Vigorous Physical Activity in Type 2 Diabetes Mellitus

Impact of Self-Reported Sitting Time and Transtheoretical Model Based on Exercise Behavior Change on Glycemic and Weight Control in Japanese Adults with Type 1 Diabetes: A Cross-Sectional Study

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