Scaphium affine Ethanol Extract Induces Anoikis by Regulating the EGFR/Akt Pathway in HCT116 Colorectal Cancer Cells

Kawk, Hye Won; Nam, Gun‐He; Kim, Do Young; Kim, Sang-Yong; Kim, Young‐Min

doi:10.3389/fonc.2021.621346

Cited by 6 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although p53 is not involved in direct inhibition of EGFR, it is known to increase sensitivity to EGFR-Tyrosin kinase inhibition. Therefore, the activity of p53 enhances the inhibition of EGFR activity by RFE, and thereby EGFR and Src activity are regulated [57][58][59]. Since increasing the sensitivity to inhibition of EGFR is one of the methods to reduce resistance to EGFR-targeted anticancer drugs, RFE has shown the potential to help overcome anticancer drug resistance.…”

Section: Discussionmentioning

confidence: 99%

The p53-Driven Anticancer Effect of Ribes fasciculatum Extract on AGS Gastric Cancer Cells

Kim

Kawk

Kim

et al. 2022

Life

Self Cite

View full text Add to dashboard Cite

Cancer metastasis is directly related to the survival rate of cancer patients. Although cancer metastasis proceeds by the movement of cancer cells, it is fundamentally caused by its resistance to anoikis, a mechanism of apoptosis caused by the loss of adhesion of cancer cells. Therefore, it was found that inhibiting cancer migration and reducing anoikis resistance are important for cancer suppression, and natural compounds can effectively control it. Among them, Ribes fasciculatum, which has been used as a medicinal plant, was confirmed to have anticancer potential, and experiments were conducted to prove various anticancer effects by extracting Ribes fasciculatum (RFE). Through various experiments, it was observed that RFE induces apoptosis of AGS gastric cancer cells, arrests the cell cycle, induces oxidative stress, and reduces mobility. It was also demonstrated that anoikis resistance was attenuated through the downregulation of proteins, such as epidermal growth factor receptor (EGFR). Moreover, the anticancer effect of RFE depends upon the increase in p53 expression, suggesting that RFE is suitable for the development of p53-targeted anticancer materials. Moreover, through xenotransplantation, it was found that the anticancer effect of RFE confirmed in vitro was continued in vivo.

show abstract

Section: Discussionmentioning

confidence: 99%

The p53-Driven Anticancer Effect of Ribes fasciculatum Extract on AGS Gastric Cancer Cells

Kim

Kawk

Kim

et al. 2022

Life

Self Cite

View full text Add to dashboard Cite

show abstract

“…In human colon cancer cells HT116, β-sitosterol reduced the expression of Bcl-2 and inhibited the apoptosis of protein-1 (cIAP1) while inducing the activation of BAX and cytochrome C. It also reduced tumor size in a dose-dependent manner and induced apoptosis in HCT116 colorectal cancer cells both in vitro and in vivo through the EGFR/Akt pathway ( Kawk et al, 2021 ). β-sitosterol also induces apoptosis through a cystathionine-dependent pathway ( Raj et al, 2022 ).…”

Section: Anti-tumor Mechanism Of Action Of the Active Ingredients Of ...mentioning

confidence: 99%

Research progress of ginseng in the treatment of gastrointestinal cancers

Song²,

Shi³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Cancer has become one of the major causes of human death. Several anticancer drugs are available; howeve their use and efficacy are limited by the toxic side effects and drug resistance caused by their continuous application. Many natural products have antitumor effects with low toxicity and fewer adverse effects. Moreover, they play an important role in enhancing the cytotoxicity of chemotherapeutic agents, reducing toxic side effects, and reversing chemoresistance. Consequently, natural drugs are being applied as potential therapeutic options in the field of antitumor treatment. As natural medicinal plants, some components of ginseng have been shown to have excellent efficacy and a good safety profile for cancer treatment. The pharmacological activities and possible mechanisms of action of ginseng have been identified. Its broad range of pharmacological activities includes antitumor, antibacterial, anti-inflammatory, antioxidant, anti-stress, anti-fibrotic, central nervous system modulating, cardioprotective, and immune-enhancing effects. Numerous studies have also shown that throuth multiple pathways, ginseng and its active ingredients exert antitumor effects on gastrointestinal (GI) tract tumors, such as esophageal, gastric, colorectal, liver, and pancreatic cancers. Herein, we introduced the main components of ginseng, including ginsenosides, polysaccharides, and sterols, etc., and reviewed the mechanism of action and research progress of ginseng in the treatment of various GI tumors. Futhermore, the pathways of action of the main components of ginseng are discussed in depth to promote the clinical development and application of ginseng in the field of anti-GI tumors.

show abstract

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects

Wang

Zhang

et al. 2023

Advances in Nutrition

View full text Add to dashboard Cite

Scaphium affine Ethanol Extract Induces Anoikis by Regulating the EGFR/Akt Pathway in HCT116 Colorectal Cancer Cells

Cited by 6 publications

References 45 publications

The p53-Driven Anticancer Effect of Ribes fasciculatum Extract on AGS Gastric Cancer Cells

The p53-Driven Anticancer Effect of Ribes fasciculatum Extract on AGS Gastric Cancer Cells

Research progress of ginseng in the treatment of gastrointestinal cancers

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects

Contact Info

Product

Resources

About