Scanning electron microscopy of the structural reconstruction of the abdominal wall after experimental paramedian incision

Rizk, Nabil N.

doi:10.1016/0022-4804(83)90012-4

Cited by 1 publication

(1 citation statement)

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“…Analyzing by scanning electron microscopy, it was found that unlike control animals, the collagen deposition in diabetic animals is markedly disorganized and composed of immature fibers with numerous “empty” not yet filled in the injured area. This finding has already been observed in our laboratory in anastomosis of small and large intestine of diabetic rats without any treatment [30]. Both studies, however, revealed that there was no change in the content of collagen in skin scars and intestines being found normal levels of OH-P and tissue protein in these tissues.…”

Section: Discussionsupporting

confidence: 73%

Continuous Electrical Current and Zinc Sulphate Administered by Transdermal Iontophoresis Improves Skin Healing in Diabetic Rats Induced by Alloxan: Morphological and Ultrastructural Analysis

Cassettari

Dias

Lucchesi

et al. 2014

Journal of Diabetes Research

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Purpose. Evaluated the effects of continuous electrical current (CEC) or zinc administrated by transdermal iontophoresis (Zn+TDI). Methods. 120 male Wistar rats were submitted to an incision surgery at the anterior region of abdomen and distributed into 6 experimental groups with 40 animals: 3 diabetic groups and 3 normal groups, untreated and treated with CEC alone or with Zn + TDI. Each group was further divided into 4 subgroups with 10 rats each to be evaluated on the 4th, 7th, 14th, and 21st day after surgery. In each period, clinical and laboratory parameters from the animals were analyzed. Results. The analysis by optical and scanning electron microscopy showed a delay in the phases of wound healing in diabetic rats without treatment in all periods of the experiment; breaking strength (BS) was significantly reduced in skin scars of untreated diabetic rats when compared to other groups. In contrast, BS in skin scars of nondiabetic groups and diabetic rats treated with Zn + TDI showed significant increase in those, besides not presenting delayed healing. Conclusion. Electrical stimulation of surgical wounds used alone or in association with zinc by TDI is able to consistently improve the morphological and ultrastructural changes observed in the healing of diabetic animals.

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Section: Discussionsupporting

confidence: 73%