Scan findings of various myocardial SPECT agents in a case of amyloid polyneuropathy with suspected myocardial involvement

Arbab, Ali S.; Koizumi, Kiyoshi; Toyama, Keiji; Arai, Takao; Yoshitomi, Tatsuya; Araki, Tsutomu

doi:10.1007/bf03164822

Cited by 13 publications

(12 citation statements)

References 4 publications

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“…This was later confirmed by others 33-35 indicating that patients with FAP have a high incidence of myocardial adrenergic denervation with viable myocardium and can be identified early in cardiac amyloidosis before clinical heart disease and echocardiographic changes. 34 Another clinical trial by Delahaye et al involving 17 patients with rectal or nerve biopsy-proven FAP found that cardiac 123 I-MIBG uptake was significantly decreased in FAP patients with no difference in washout rates despite preserved left ventricle systolic function and cardiac perfusion.…”

Section: Methodsmentioning

confidence: 57%

Nuclear imaging modalities for cardiac amyloidosis

Bokhari

Shahzad²,

Castaño

et al. 2014

Journal of Nuclear Cardiology

105

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Amyloidosis is a heterogeneous group of diseases characterized by localized or systemic deposition of insoluble extracellular fibrillary proteins in organs and tissues. Several types of amyloid can infiltrate the heart resulting in a restrictive cardiomyopathy, heart failure, and atrial and ventricular arrhythmias. Scintigraphy is a noninvasive method that may facilitate early diagnosis, distinguish various forms of cardiac amyloid, and may be useful in following disease burden. The amyloid-specific tracers presented in this article have been used with planar imaging and/or single-photon emission computed tomography. To date, there are no approved cardiac amyloid tracers although investigational tracers are currently under examination. This article serves to review the current nuclear imaging modalities available in the detection of cardiac amyloid.

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Section: Methodsmentioning

confidence: 57%

Nuclear imaging modalities for cardiac amyloidosis

Bokhari

Shahzad²,

Castaño

et al. 2014

Journal of Nuclear Cardiology

105

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“…The SPECT images showed abnormal uptake of the tracer in the heart. They suggested that in this patient either 99m Tc-DMSA or 123 I-MIBG may be useful to detect involvement of the heart by the amyloid process [12].…”

Section: I-bmippmentioning

confidence: 91%

“…99m Tc (V)-DMSA showed some myocardial involvement of amyloidosis, and 201 Tl and 123 I-BMIPP showed normal blood perfusion and normal fatty acid metabolism, respectively (all these tracers are discussed below in this review). The decreased uptake of MIBG in the heart indicated a severe impairment of sympathetic function [12].…”

Section: I-mibgmentioning

confidence: 99%

Nuclear imaging in cardiac amyloidosis

Glaudemans

Slart

Zeebregts

et al. 2009

Eur J Nucl Med Mol Imaging

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Amyloidosis is a disease characterized by depositions of amyloid in organs and tissues. It can be localized (in just one organ) or systemic. Cardiac amyloidosis is a debilitating disease and can lead to arrhythmias, deterioration of heart function and even sudden death. We reviewed PubMed/Medline, without time constraints, on the different nuclear imaging modalities that are used to visualize myocardial amyloid involvement. Several SPECT tracers have been used for this purpose. The results with these tracers in the evaluation of myocardial amyloidosis and their mechanisms of action are described. Most clinical evidence was found for the use of 123 I-MIBG. Myocardial defects in MIBG activity seem to correlate well with impaired cardiac sympathetic nerve endings due to amyloid deposits. 123 I-MIBG is an attractive option for objective evaluation of cardiac sympathetic level and may play an important role in the indirect measurement of the effect of amyloid myocardial infiltration. Other, less sensitive, options are 99m Tc-aprotinin for imaging amyloid deposits and perhaps 99m Tc-labelled phosphate derivatives, especially in the differential diagnosis of the aetiology of cardiac amyloidosis. PET tracers, despite the advantage of absolute quantification and higher resolution, are not yet well evaluated for the study of cardiac amyloidosis. Because of these advantages, there is still the need for further research in this field.

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“…Its uptake in AL amyloidosis was described by Ohta et al [31] and Kobayashi et al [22]. Disadvantage of 99m Tc-penta-DMSA is its relatively high blood-pool concentration making the assessment of tissue uptake difficult, which was minimized by delayed image registration after 24h post injection and described by Arbab et al [32]. …”

Section: Radiotracers Used For Imaging Of Amyloid Depositsmentioning

confidence: 99%

“…The isotope used was 131 I and β2M was extracted from uremic hemofiltrate. The radiotracer is accumulated directly in amyloid deposits [32]. A disadvantage of 131 I-labeled radiotracer was poor spatial resolution, which made imaging of small joints problematic and increased the radiation dose due to unnecessary β(−) radiation [34].…”

Section: Radiotracers Used For Imaging Of Amyloid Depositsmentioning

confidence: 99%

Nuclear imaging of amyloidosis

2014

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SummaryAmyloidosis is a clinical condition caused by deposition of various protein fibrills in extracellular space. The presented symptoms depend on the type of deposits and the organ or organs involved. The correct diagnosis is often difficult, due to lack of nonivasive imaging techniques and insufficiency of morphological imaging procedures delievered by radiology. We presented a list of potential radiopharmaceuticals that can be used in detecting various types of amyloidoses. 123I-SAP proved to have high sensitivity in imaging of AA and AL amyloidosis in visceral organs. 99mTc-Aprotinin was found to be useful in detecting cardiac amyloidosis. A couple of classical radiotracers, such as 201Tl, 123I-mIBG, together with 111In-antimyosin were also tested for accuracy in cardiac imaging, however the main problem was low specificity. Potential applicability was also found in case of some bone-seeking agents and other radiotracers, e.g. 67Ga-citrate and 99mTc-penta-DMSA. High sensitivity and specificity was achieved with β2-microglobulin labeled with 131I or 111In. Among PET tracers, 11C-PIB deserves more attention, because it may have an important role in diagnosing of AD in the near future. Further clinical studies are expected to take place, because noninvasive diagnosing and monitoring of amyloidosis is still a challenge.

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Scan findings of various myocardial SPECT agents in a case of amyloid polyneuropathy with suspected myocardial involvement

Cited by 13 publications

References 4 publications

Nuclear imaging modalities for cardiac amyloidosis

Nuclear imaging modalities for cardiac amyloidosis

Nuclear imaging in cardiac amyloidosis

Nuclear imaging of amyloidosis

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