Nuclear imaging of amyloidosis

Cytawa, Wojciech; Teodorczyk, Jacek; Lass, Piotr

doi:10.12659/pjr.890147

Cited by 12 publications

(3 citation statements)

References 34 publications

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“…Unfortunately, the method is complex; requires sophisticated materials, technology, and equipment; and is very expensive. 21 Our second patient underwent this SAP scintigraphy scan at the National Amyloidosis Centre, United Kingdom, which did not show any visceral amyloid deposits and, thus, systemic amyloidosis was ruled out.…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Plasma Cell Neoplasms with Amyloidosis of the Head and Neck Region: A Series of two Rare Cases and Literature Review

Nerurkar¹,

Gala²,

Shah³

et al. 2018

International Journal of Phonosurgery &Amp; Laryngology

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Extramedullary plasmacytomas (EMP) are rare malignant plasma cell neoplasms (PCNs) mainly affecting the head and the neck region. These are more commonly seen in adult males. These have variable outcomes and may even coexist with, or progress to multiple myelomas (MMs). Hence, a systemic examination is a must, to rule out generalized involvement. The presence of monoclonal plasma cells on histopathology explains the relationship of PCNs with amyloidosis. Treatment may be surgical for accessible tumors or low to moderate dose radiation as indicated. Long-term surveillance is a must. We discuss two cases of extramedullary PCNs with amyloidosis involving the head-neck region. Both the patients underwent surgical excision followed by radiation for the residual disease and recurrence prevention. Systemic involvement was ruled out and the patients have been advised regular follow-up.

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Section: Discussionmentioning

confidence: 99%

Extramedullary Plasma Cell Neoplasms with Amyloidosis of the Head and Neck Region: A Series of two Rare Cases and Literature Review

Nerurkar¹,

Gala²,

Shah³

et al. 2018

International Journal of Phonosurgery &Amp; Laryngology

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“…Instead, other radiotracers are more suitable such as 123 I- serum amyloid P component (SAP) for Single Photon Emission Computed Tomography (SPECT), 99m Tc-Aprotinin (SPECT) or 11 C-Pittsburgh compound B (PIB) for Positron emission tomography (PET). [23] .…”

Section: Discussionmentioning

confidence: 99%

Is there a role for 18F-FDG PET-CT in Familial Mediterranean fever? A case report and overview of the literature

Ibrahim

Smeets

Goethals

2021

Radiology Case Reports

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Familial Mediterranean Fever (FMF) is an autosomal recessive disorder that is characterised by recurrent attacks of fever and painful polyserositis mainly affecting the peritoneum, synovium and pleura that usually begins in childhood. Even though diagnostic criteria have been proposed, conclusive imaging findings or haematological markers for the diagnosis or follow-up of FMF are still lacking. In this case report we present the 18 F-FDG PET-CT findings in a 55 year old female during an attack of FMF. We briefly discuss the added value of 18 F-FDG PET-CT in the diagnosis and the work-up of FMF, which may open up new applications for 18 F-FDG PET-CT in non-infectious inflammatory diseases.

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“…SAP scintigraphy is highly sensitive for AL and AA amyloidosis (90% for both subtypes), with a specificity of 93%. The use of SAP scintigraphy may give a more definitive answer regarding the presence of systemic disease however the modiality itself is often not available in local centres [17,18]. usually not employed due to their side effect profile [16].…”

Section: Discussionmentioning

confidence: 99%

Localised Cutaneous Amyloidosis of the Glans Penis: A Case Report and Review of the Literature

Hyett¹

2021

IJCIMR

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Amyloidosis represents a notable cause of morbidity within the developed world. Urological presentations of systemic or localised amyloidosis are rare, with penile amyloidosis being poorly reported.We performed a literature review investigating cases of penile cutaneous amyloidosis via the PubMed database during March 2020, in conjunction with clinical review of a local patient presenting with a penile lesion.Our patient is a 60 year old uncircumcised, caucasian male presenting with a longstanding history of 2 irregular lesions affecting his glans penis and a further 2 lesions affecting the inner surface of his prepuce. He underwent excision biopsy of the largest lesion which represented cutaneous amyloid deposits. He underwent immunological testing for systemic disease which was negative.In current literature, there are 13 cases of cutaneous amyloidosis affecting the glans penis, with 1 of those having evidence of extra genitourinary amyloid deposits. All the documented cases were treated with local excision and investigation for systemic disease.It is important to recognise alternative diagnoses in patients presenting with penile lesions. Despite cutaneous amyloidosis mimicking malignancy macroscopically, the morbidity and mortality is lower in comparison to penile cancer. Treatment remains surgical excision of the lesion and further investigations to exclude systemic disease.

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Nuclear imaging of amyloidosis

Cited by 12 publications

References 34 publications

Extramedullary Plasma Cell Neoplasms with Amyloidosis of the Head and Neck Region: A Series of two Rare Cases and Literature Review

Extramedullary Plasma Cell Neoplasms with Amyloidosis of the Head and Neck Region: A Series of two Rare Cases and Literature Review

Is there a role for 18F-FDG PET-CT in Familial Mediterranean fever? A case report and overview of the literature

Localised Cutaneous Amyloidosis of the Glans Penis: A Case Report and Review of the Literature

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