Is there a role for 18F-FDG PET-CT in Familial Mediterranean fever? A case report and overview of the literature

Abstract

Familial Mediterranean Fever (FMF) is an autosomal recessive disorder that is characterised by recurrent attacks of fever and painful polyserositis mainly affecting the peritoneum, synovium and pleura that usually begins in childhood. Even though diagnostic criteria have been proposed, conclusive imaging findings or haematological markers for the diagnosis or follow-up of FMF are still lacking. In this case report we present the 18 F-FDG PET-CT findings in a 55 year old female during an attack of FMF. We briefly discuss the added value of 18 F-FDG PET-CT in the diagnosis and the work-up of FMF, which may open up new applications for 18 F-FDG PET-CT in non-infectious inflammatory diseases.