Scaling up of renewable chemicals

Sanford, Karl; Chotani, Gopal; Danielson, Nathan; Zahn, James A.

doi:10.1016/j.copbio.2016.01.008

Cited by 88 publications

(46 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other organisms such as Clostridium and Pseudomonas can be used to produce alternative biochemicals (Ragauskas et al ., 2014; Tolonen et al ., 2015; Ramos et al ., 2016; Sanford et al ., 2016). …”

Section: Lignocellulosic Facility Process Descriptionmentioning

confidence: 99%

“…The saccharification is followed by simultaneous fermentation of xylose and glucose to ethanol using a genetically modified strain of brewer's yeast (Saccharomyces cerevisiae). Other organisms such as Clostridium and Pseudomonas can be used to produce alternative biochemicals (Ragauskas et al, 2014;Tolonen et al, 2015;Ramos et al, 2016;Sanford et al, 2016).…”

Section: Lignocellulosic Facility Process Descriptionmentioning

confidence: 99%

See 1 more Smart Citation

Biofuels 2020: Biorefineries based on lignocellulosic materials

Valdivia

Galán-González

Briones

et al. 2016

Microbial Biotechnology

204

101

View full text Add to dashboard Cite

SummaryThe production of liquid biofuels to blend with gasoline is of worldwide importance to secure the energy supply while reducing the use of fossil fuels, supporting the development of rural technology with knowledge‐based jobs and mitigating greenhouse gas emissions. Today, engineering for plant construction is accessible and new processes using agricultural residues and municipal solid wastes have reached a good degree of maturity and high conversion yields (almost 90% of polysaccharides are converted into monosaccharides ready for fermentation). For the complete success of the 2G technology, it is still necessary to overcome a number of limitations that prevent a first‐of‐a‐kind plant from operating at nominal capacity. We also claim that the triumph of 2G technology requires the development of favourable logistics to guarantee biomass supply and make all actors (farmers, investors, industrial entrepreneurs, government, others) aware that success relies on agreement advances. The growth of ethanol production for 2020 seems to be secured with a number of 2G plants, but public/private investments are still necessary to enable 2G technology to move on ahead from its very early stages to a more mature consolidated technology.

show abstract

Section: Lignocellulosic Facility Process Descriptionmentioning

confidence: 99%

Section: Lignocellulosic Facility Process Descriptionmentioning

confidence: 99%

Biofuels 2020: Biorefineries based on lignocellulosic materials

Valdivia

Galán-González

Briones

et al. 2016

Microbial Biotechnology

204

101

View full text Add to dashboard Cite

show abstract

“…The transition of promising technologies for industrial applications from lab-scale to commercial scale is confronted with severe scale-up challenges (Sanford, Chotani, Danielson, & Zahn, 2016). Loss of production performance is a frequently encountered issue as manufacturing scale increases from several liters to hundreds of cubic meters.…”

Section: Metabolomics-assisted Systems Biology and Synthetic Biologmentioning

confidence: 99%

Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses

Wang

Haringa

Tang

et al. 2019

Biotech & Bioengineering

View full text Add to dashboard Cite

Metabolomics aims to address what and how regulatory mechanisms are coordinated to achieve flux optimality, different metabolic objectives as well as appropriate adaptations to dynamic nutrient availability. Recent decades have witnessed that the integration of metabolomics and fluxomics within the goal of synthetic biology has arrived at generating the desired bioproducts with improved bioconversion efficiency. Absolute metabolite quantification by isotope dilution mass spectrometry represents a functional readout of cellular biochemistry and contributes to the establishment of metabolic (structured) models required in systems metabolic engineering. In industrial practices, population heterogeneity arising from fluctuating nutrient availability frequently leads to performance losses, that is reduced commercial metrics (titer, rate, and yield). Hence, the development of more stable producers and more predictable bioprocesses can benefit from a quantitative understanding of spatial and temporal cell-to-cell heterogeneity within industrial bioprocesses. Quantitative metabolomics analysis and metabolic modeling applied in computational fluid dynamics (CFD)-assisted scale-down simulators that mimic industrial heterogeneity such as fluctuations in nutrients, dissolved gases, and other stresses can procure informative clues for coping with issues during bioprocessing scale-up. In previous studies, only limited insights into the hydrodynamic conditions inside the industrial-scale bioreactor have been obtained, which makes case-by-case scale-up far from straightforward. Tracking the flow paths of cells circulating in large-scale bioreactors is a highly valuable tool for evaluating cellular performance in production tanks. The "lifelines" or "trajectories" of cells in industrial-scale bioreactors can be captured using Euler-Lagrange CFD simulation. This novel methodology can be further coupled with metabolic (structured) models to provide not only a statistical analysis of cell lifelines triggered by the environmental fluctuations but also a global assessment of the metabolic response to heterogeneity inside an industrial bioreactor. For the future, the industrial design should be dependent on the computational framework, and this integration work will allow bioprocess scale-up to the industrial scale with an end in mind. K E Y W O R D SCFD, Euler-Langrange, metabolic model, metabolomics, population heterogeneity, scale down

show abstract

“…Biobased polymers have emerged as a green alternative to petrochemical based materials. The worldwide production of biobased polymers has increased at a rate of 3%–4% per year and it is estimated that by 2020 their production will reach 12 million tons . Biobased polymers have been focused traditionally on agricultural feedstocks such as corn, potatoes and other carbohydrate feedstocks.…”

Section: Introductionmentioning

confidence: 99%

Development of high‐modulus thermoset materials based on bioglycerol

Gómez

Echeverri

Inciarte

et al. 2019

Polymer International

View full text Add to dashboard Cite

A high‐value application of crude bioglycerol in polymers was developed. In this application, bioglycerol was first transformed into a highly polyunsaturated resin (MAGLYMA) through maleinization–methacrylation reactions, under mild conditions (80–90 °C, 1–2 h). The resin was copolymerized with methyl methacrylate (MMA) (20%–50%) at room temperature over 8 h, affording rigid materials. The effect of MMA content on the mechanical and thermal properties was evaluated. The flexural modulus, flexural strength and surface hardness of the materials were around 3800 MPa, 130–180 MPa and 77 (Shore D), respectively. Tg values were in the range 92–105 °C. It is remarkable that excellent mechanical and thermal properties were obtained using a low concentration of MMA (20%). In particular, the mechanical properties of this material were better than those obtained for a commercial unsaturated polyester thermoset. © 2019 Society of Chemical Industry

show abstract

Scaling up of renewable chemicals

Cited by 88 publications

References 28 publications

Biofuels 2020: Biorefineries based on lignocellulosic materials

Biofuels 2020: Biorefineries based on lignocellulosic materials

Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses

Development of high‐modulus thermoset materials based on bioglycerol

Contact Info

Product

Resources

About