Scale‐up of single phase axial dispersion coefficients in batch and continuous oscillatory baffled tubes

Ni, Xiongwei; Gélicourt, Yann Sommer de; Baird, M. H. I.; Rao, N. V. Rama

doi:10.1002/cjce.5450790318

Cited by 31 publications

(37 citation statements)

References 26 publications

(12 reference statements)

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“…The main innovations of this micro-bioreactor are the very good control of mixing and mass transfer rates, simply by setting the fluid oscillation conditions (Reis et al 2005). Furthermore, studies with bench-scale oscillatory flow reactors demonstrated the linear scale-up of baffled reactors based on oscillatory flow (Ni & Gao 1996, Ni et al 2001, thus optimisations achieved here can be applied at industrial scale.…”

Section: Introductionmentioning

confidence: 94%

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

et al. 2006

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A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of c-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in c-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o $482 to Re o $1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area.

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Section: Introductionmentioning

confidence: 94%

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

et al. 2006

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“…Ni et al [37] compared the axial dispersion coefficient for different pulsed devices (close-fit, loose-fit baffle, Karr plate and multiperforated plate of various scales). They demonstrated that the axial dispersion coefficient is proportional to the mean energy dissipation rate and to the geometrical characteristics of the system, as follows:…”

Section: Axial Dispersionmentioning

confidence: 99%

“…The batch configurations have been extensively described in literature [6,[34][35][36][37][38][39][40][41]. Table 2 lists the different parameters affecting droplet size and the correspondent correlations for oscillatory baffled reactor in batch.…”

Section: Introductionmentioning

confidence: 99%

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Lobry

Lasuye²,

Gourdon

et al. 2015

Chemical Engineering Journal

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible.Liquid-liquid dispersion in a continuous oscillatory baffled reactor -Application to suspension polymerization b s t r a c tReducing energy costs, improving safety, minimizing waste are the current aims of chemical engineering. Process intensification in fine chemistry has been extensively studied but less work refers to heterogeneous reactions involving two liquid phases. This paper focuses on batch to continuous suspension polymerization transposition and especially on the liquid-liquid dispersion step. The main features of suspension polymerization reaction are based on (i) the initial liquid-liquid dispersion requiring a controlled size and narrow distribution and (ii) on the control of the final particle size during the agglomeration step by avoiding fouling which is a bottleneck for continuous flow. For the continuous transposition, liquid-liquid dispersion and reaction studies are carried out in continuous oscillatory baffled reactor (COBR) which is a multipurpose reactor. Its suitability to overcome the bottlenecks is demonstrated through the investigation of the oscillating and flow conditions or the dispersed phase holdup. A controlled droplet size distribution can be achieved. Oscillation is the main parameter responsible for droplet breakage. The suitable conditions to obtain stable dispersion are determined. For one of the first times, COBR is used for suspension polymerization.

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“…Up to date, only three studies have been carried out on scaling up “conventional OBR” . “Conventional” denotes equally spaced single‐orifice baffles.…”

Section: Introductionmentioning

confidence: 99%

“…Scale‐up correlations, E ( d h ) (Eq. 7) and E ( Re n , Re o ) (Eq. 8) based on the RTD were established; however, they were based on data from only one scale.…”

Section: Introductionmentioning

confidence: 99%

Scale‐Up of Oscillatory Helical Baffled Reactors Based on Residence Time Distribution

2017

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For the first time, the scale‐up of oscillatory helical baffled reactors (OHBR) was studied. Residence time distributions were used to assess the scale‐up over a wide range of net flow Reynolds numbers and oscillation conditions. A simple scale‐up correlation based on oscillation and net flow conditions was established to predict the plug flow behavior at various reactor scales. It is suggested that operating conditions can be easily extrapolated from the laboratory scale to the pilot scale, and even to industrial scales, as the mixing behavior is similar.

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Scale‐up of single phase axial dispersion coefficients in batch and continuous oscillatory baffled tubes

Abstract: scillatory Flow Mixing (OFM in short) is a relatively recent development in mixing technology, which has been researched 0 over the past decade (Mackley, 1987; Howes, 1988; Brunold et al., 1989; Dickens et al .

Cited by 31 publications

References 26 publications

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

Application of a Novel Oscillatory Flow Micro-bioreactor to the Production of γ-decalactone in a Two Immiscible Liquid Phase Medium

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Scale‐Up of Oscillatory Helical Baffled Reactors Based on Residence Time Distribution

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