Scale-up concept of single-channel microreactors from process development to industrial production

Kockmann, Norbert; Gottsponer, Michael; Roberge, Dominique M.

doi:10.1016/j.cej.2010.08.089

Cited by 202 publications

(154 citation statements)

References 22 publications

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“…Another example of scale-up of a continuous flow microreactor has been reported for a two-step Li-H exchange and coupling reaction [1]. The first step is a reaction of class 1) with a considerable adiabatic temperature rise, while the second is class 2) without particular needs for heating and mixing.…”

Section: Type Of Reactormentioning

confidence: 99%

“…A single channel design, with rectangular shape, with no flow partialisation has been selected as most appropriate for simpler scale-up. The key adimensional numbers and appropriate correlations are reported by Kochmann et al [1], to compute pressure drop (mainly accounted for in the mixing zone), heat and mass transfer coefficients. The comparison between the reaction carried out in different tools and with reactors of different size is reported in Table 4.…”

Section: Type Of Reactormentioning

confidence: 99%

“…This allows a thin tube for the initial stages of reaction, to better control the heat release, followed by pipe enlargement when heat release control is less demanding, to limit the pressure drop. Furthermore, the different reactor plates, made of stainless steel, are thermally coupled with aluminum plates holding the heating/cooling fluid, in order to enhance heat transport [1]. Table 3.…”

Section: Scale-up Issuesmentioning

confidence: 99%

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Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti

Compagnoni

2016

Chemical Engineering Journal

200

103

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Flow chemistry has been proposed in modern organic chemistry as a mean for process intensification, to improve the control over reaction performance and to achieve higher yield. However, many open issues can be evidenced regarding the true possibility of scale-up, as well as currently lacking information for process design and economical evaluation. This review proposes some recent examples of flow synthesis deepening in particular the scale-up and engineering issues. Required information is evidenced, as well as some transport and kinetic data required for the practical implementation of the results.

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Section: Type Of Reactormentioning

confidence: 99%

Section: Type Of Reactormentioning

confidence: 99%

Section: Scale-up Issuesmentioning

confidence: 99%

See 1 more Smart Citation

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti

Compagnoni

2016

Chemical Engineering Journal

200

103

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“…Researchers from Lonza have developed the FlowPlate TM 34 concept, which allows for a reliable scale-up of flow chemistry from lab scale to pilot plant production ( Figure 17). 202 The FlowPlate reactor consists of a stack of stainless steel reactor plates, containing tangential mixing elements, and thermal conductive aluminium plates, ensuring an excellent heat dissipation. 145 The hydraulic diameter can be gradually increased by using different reactor plates (from lab plate, A6, A5 to A4 plates).…”

Section: Scalabilitymentioning

confidence: 99%

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

Noël

Hessel

2015

Topics in Organometallic Chemistry

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Flow chemistry is typically used to enable challenging reactions which are difficult to carry out in conventional batch equipment. Consequently, the use of continuous-flow reactors for applications in organometallic and organic chemistry has witnessed a spectacular increase in interest from the chemistry community in the last decade. However, flow chemistry is more than just pumping reagents through a capillary and the engineering behind the observed phenomena can help to exploit the technology's full potential. Here, we give an overview of the most important engineering aspects associated with flow chemistry. This includes a discussion of mass-, heat-, and photon-transport phenomena which are relevant to carry out chemical reactions in a microreactor. Next, determination of intrinsic kinetics, automation of chemical processes, solids handling and multistep reaction sequences in flow are discussed. Safety is one of the main drivers to implement continuous-flow microreactor technology in an existing process and a brief overview is given here as well. Finally, the scale-up potential of microreactor technology is reviewed.

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“…[8][9][10][11][12][13] The field has expanded in scope beyond single reactor and synthesis steps to multistep synthesis including intermediate workup and separation steps. [14][15][16][17][18][19] Among the separation techniques available to organic chemists, liquidliquid separations are becoming more popular.…”

Section: Introductionmentioning

confidence: 99%

Membrane-Based, Liquid–Liquid Separator with Integrated Pressure Control

Adamo

Heider

Weeranoppanant

et al. 2013

Ind. Eng. Chem. Res.

164

175

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We describe the development and application of an improved, membrane-based, liquid-liquid separator. Membrane based separation relies on the exploitation of surface forces and the use of a membrane wetted by one of the phases; however, successful separation requires accurate control of pressures making the operation and implementation cumbersome. Here we present an improved separator design that integrates a pressure control element to ensure that adequate operating conditions are always maintained. Additionally, the integrated pressure control decouples the separator from downstream unit operations. A detailed examination of the controlling physical equations shows how to design the device to allow operation across a wide range of conditions. Easy to implement, multistage separations such as solvent swaps and countercurrent extractions are demonstrated. The presented design significantly simplifies applications ranging from multistep synthesis to complex multistage separations.

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Scale-up concept of single-channel microreactors from process development to industrial production

Cited by 202 publications

References 22 publications

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

Membrane-Based, Liquid–Liquid Separator with Integrated Pressure Control

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