Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti, Ilenia; Compagnoni, Matteo

doi:10.1016/j.cej.2016.02.119

Cited by 182 publications

(104 citation statements)

References 150 publications

(149 reference statements)

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“…In addition, the micromixing mechanism is a core topic in crystallization and other flow chemistry relevant process, which determines the distribution of supersaturation degree, process efficiency and quality of products . The droplet surface area is the limitation, and the diffusion resistance is high .…”

Section: Introductionmentioning

confidence: 99%

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

et al. 2018

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Herein, a novel hollow fiber membrane‐assisted antisolvent crystallization (MAAC) was proposed to enhance the mass transfer control over the antisolvent crystallization. A polyethersulfone membrane module was introduced as the key device for antisolvent transfer and solution mixing. An antisolvent liquid film layer was formed on the membrane surface and mixed with the solution. The liquid film also prevented the membrane from directly contacting with crystallization solution. By controlling both the shell side flow velocity and the antisolvent transfer, the antisolvent permeation rate achieved sensitive, stable, and accurate control during long‐term and repeated utilization. The interfacial mass transfer rate of MAAC was 0.66 mg cm−2 s−1, which was only 1/50 that of conventional droplet antisolvent crystallization. MAAC also provided crystal products with better morphologies and narrower size distributions than the conventional process. The stable performances of MAAC in terms of its accurate antisolvent mass transfer and antifouling capabilities were also highlighted. © 2018 American Institute of Chemical Engineers AIChE J, 65: 734–744, 2019

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Section: Introductionmentioning

confidence: 99%

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

et al. 2018

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“…The bulk chemical industry has likewise pursued the miniaturization of unit operations (e.g., compact heat exchanger‐reactors) as means of process intensification and modular manufacturing towards concepts of Industry 4.0/Smart Factory, albeit typically at the millimetre‐scale in order to meet production rates . As a result, the literature has expanded from less than 100 articles a year in the early 1990s to 583 articles as of July 2018, with new potential applications, monographs, reviews, and perspective articles, which were written along with dedicated journals or journal sub‐sections (e.g., Lab on a Chip, Journal of Flow Chemistry, Chemical Engineering and Processing: Process Intensification, Chemistry Today ) and conferences (e.g., International Conference on Micro Reaction Technology, International Conference on Nanochannels, Microchannels, and Minichannels).…”

Section: Introductionmentioning

confidence: 99%

Experimental methods in chemical engineering: Micro‐reactors

et al. 2019

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Whereas the bulk chemical industry has historically sought economic advantage through economies of scale, a paradigm shift has researchers developing systems on smaller scales. Nano-cages and nano-actuators increase selectivity and robustness at the molecular scale. In parallel, micro-contactors with sub-millimetre lateral dimensions are decreasing boundary layers that restrict heat and mass transfer and thus meet the objectives of process intensification with great increases in productivity with a smaller footprint. These contactors continue to serve chemical engineers and chemists to synthesize fine chemicals and characterize catalysts; however, they have now been adopted for sensors in biological and biochemical systems. A bibliometric analysis of articles indexed in the Web of Science in 2016 and 2017 identified five major clusters of research: catalysis and bulk chemicals; nanoparticles; organic synthesis and flow chemistry; systems and micro-fluidics applied to biochemistry; and micro-channel reactors and mass transfer. In the early 1990s, less than 100 articles a year mentioned micro-reactors, while over 943 articles mentioned it in 2017. Here, we introduce micro-reactors and their role in the continuous synthesis of fine chemicals across the various scales to commercialization.

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“…Reactor amplification refers to the design and manufacture of reactors based on experimental data obtained from laboratory reaction equipment; the designed reactors are compatible with large-scale reactions during industrial production [6][7][8][9][10][11]. The design of reactor amplification needs to follow certain criteria such as theoretical amplification for the momentum, mass and energy balance equations of the reaction system [12,13].…”

Section: Introductionmentioning

confidence: 99%

Simulation of the Scale-up Process of a Venturi Jet Pyrolysis Reactor

Lv¹,

Zhang²,

Hao³

2019

Metals

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Micro- and nano-sized cerium oxide particles can be prepared through pyrolyzing cerium chloride solution directly in the venturi jet pyrolysis reactor. Micro- and nano-sized cerium oxide particles have better performance and higher application value. To increase the production of micro-and nano-sized cerium oxide, it is necessary to scale up the venturi jet pyrolysis reactor. According to the geometric similarity principle, the scale-up of the venturi jet pyrolysis reactors utilize dimensional analysis methods, with FLUENT13.0 and user-defined functions, following the mathematical simulation of the resulting enlarged reactors. After the dimensional analysis, the empirical formula obtained between the reactants and all the parameters is Q = 2.240727 × 10−4P0.004568ρ0.26223d−0.24801V1.25714n0.076479μ−0.26628, and the geometrical scale-up of the reactors needs to follow V = 0.0209d0.196. The results in this study can provide data support for the future optimization and amplification of reactors.

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Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Cited by 182 publications

References 150 publications

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

Experimental methods in chemical engineering: Micro‐reactors

Simulation of the Scale-up Process of a Venturi Jet Pyrolysis Reactor

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