A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

Abstract

Herein, a novel hollow fiber membrane‐assisted antisolvent crystallization (MAAC) was proposed to enhance the mass transfer control over the antisolvent crystallization. A polyethersulfone membrane module was introduced as the key device for antisolvent transfer and solution mixing. An antisolvent liquid film layer was formed on the membrane surface and mixed with the solution. The liquid film also prevented the membrane from directly contacting with crystallization solution. By controlling both the shell side flow velocity and the antisolvent transfer, the antisolvent permeation rate achieved sensitive, stable, and accurate control during long‐term and repeated utilization. The interfacial mass transfer rate of MAAC was 0.66 mg cm−2 s−1, which was only 1/50 that of conventional droplet antisolvent crystallization. MAAC also provided crystal products with better morphologies and narrower size distributions than the conventional process. The stable performances of MAAC in terms of its accurate antisolvent mass transfer and antifouling capabilities were also highlighted. © 2018 American Institute of Chemical Engineers AIChE J, 65: 734–744, 2019

Micromixing in a gas–liquid vortex reactor

“…organic synthesis) 5,21‐25 . To target these process performance indicators, the micromixing performance of the reactors is a key factor 26,27 …”

Membrane-Assisted Antisolvent Crystallization: Interfacial Mass-Transfer Simulation and Multistage Process Control

“…There are a number of powerful tools to optimize the crystallization process from model to experimental aspects: the population balance equation model can be used to simulate process productivity according to different operating conditions; , a combined crystallization–milling process; and optimization of the crystallizer sequence. , Membrane-assisted crystallization was originally used for solvent removal; , it can not only significantly enlarge the design space and attainable region but also decrease the energy conversion. Recently, a precise supersaturation control mechanism was proposed via constructing a permeating antisolvent layer at the polymeric membrane microscale interface, − which was mentioned as membrane-assisted antisolvent crystallization (MAAC), a novel hybrid crystallization process. A hollow fiber membrane module was introduced to provide ultralarge surface contact between the two fluids (antisolvent–crystallization solution), allowing sufficient contact time and area for mass transfer in a thin liquid layer.…”

“…Recently, a precise supersaturation control mechanism was proposed via constructing a permeating antisolvent layer at the polymeric membrane microscale interface, − which was mentioned as membrane-assisted antisolvent crystallization (MAAC), a novel hybrid crystallization process. A hollow fiber membrane module was introduced to provide ultralarge surface contact between the two fluids (antisolvent–crystallization solution), allowing sufficient contact time and area for mass transfer in a thin liquid layer. This liquid layer mass-transfer process has been investigated as the liquid membrane renewal theory. , However, the presented work only focused on the overall transmembrane permeate flux.…”

“…47,48 Membraneassisted crystallization was originally used for solvent removal; 49,50 it can not only significantly enlarge the design space and attainable region but also decrease the energy conversion. Recently, a precise supersaturation control mechanism was proposed via constructing a permeating antisolvent layer at the polymeric membrane microscale interface, 51−56 which was mentioned as membrane-assisted antisolvent crystallization (MAAC), 57 a novel hybrid crystallization process. A hollow fiber membrane module was introduced to provide ultralarge surface contact between the two fluids (antisolvent−crystallization solution), 57 allowing sufficient contact time and area for mass transfer in a thin liquid layer.…”

Modeling of Membrane-Assisted Seeded Batch Crystallization

“…Crystallization may happen on the membrane surface, in the bore of a hollow fiber membrane, or in a separate vessel (crystallizer) . Membranes can also be used in conjunction with antisolvent. − Membrane-assisted crystallization processes can be operated in batch, semibatch, or continuous mode.…”