This paper shows how a bus topology performs as a System-on-Chip (SoC) interconnection. We measure and analyze Heterogeneous IP Block Interconnection (HIBI) bus for a multiple clock domain, Multiprocessor System-on-Chip (MPSoC) with an MPEG-4 video encoding application on FPGA. The studied MPSoC contains up to 22 IP blocks: 11 soft processors, 8 hardware accelerators and three other components. A novel approach of frequency scaling is used to isolate the impact of various architecture components. The system is benchmarked in various configurations. For example, HIBI is run at 100× speed with respect to processors to resemble ideal interconnection. Based on the measurements with up to 16.9frames/s CIF (352 × 288) encoding speed, estimation for HDTV resolution video encoder is presented. The required optimizations are discussed. Finally, it is shown that 25frames/s 1280 × 720 video encoder needs 55 MHz HIBI but 670 MHz general-purpose soft RISC processors. In practice, the processing performance has to be boosted by implementing hardware acceleration and improving memory hierarchy. Clearly, HIBI is not the limiting factor.