An innovative, recently introduced, methodology for microwave power amplifier design, is here extended to switchingmode Class-E amplifier operation. Such a technique is based on a complete and accurate electron device (ED) characterization, which is provided by both direct large-signal low-frequency I/V measurements, performed by means of a relatively simple lowcost setup, and a model-based description of nonlinear reactive effects related to ED capacitances. In order to verify the proposed design methodology, a Class-E power amplifier (PA) has been designed.